Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets T Ulven Frontiers in endocrinology 3, 111, 2012 | 291 | 2012 |
Gut dysbiosis during influenza contributes to pulmonary pneumococcal superinfection through altered short-chain fatty acid production V Sencio, A Barthelemy, LP Tavares, MG Machado, D Soulard, C Cuinat, ... Cell reports 30 (9), 2934-2947. e6, 2020 | 271 | 2020 |
Emerging roles of DP and CRTH2 in allergic inflammation E Kostenis, T Ulven Trends in molecular medicine 12 (4), 148-158, 2006 | 247 | 2006 |
Complex pharmacology of free fatty acid receptors G Milligan, B Shimpukade, T Ulven, BD Hudson Chemical Reviews 117 (1), 67-110, 2017 | 236 | 2017 |
The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to … BD Hudson, B Shimpukade, AE Mackenzie, AJ Butcher, JD Pediani, ... Molecular pharmacology 84 (5), 710-725, 2013 | 196 | 2013 |
Discovery of a potent and selective GPR120 agonist B Shimpukade, BD Hudson, CK Hovgaard, G Milligan, T Ulven Journal of medicinal chemistry 55 (9), 4511-4515, 2012 | 196 | 2012 |
Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation L Uller, JM Mathiesen, L Alenmyr, M Korsgren, T Ulven, T Högberg, ... Respiratory research 8, 1-10, 2007 | 165 | 2007 |
Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival A Theiler, T Bärnthaler, W Platzer, G Richtig, M Peinhaupt, S Rittchen, ... Journal of Allergy and Clinical Immunology 144 (3), 764-776, 2019 | 162 | 2019 |
Discovery of Potent and Selective Agonists for the Free Fatty Acid Receptor 1 (FFA1/GPR40), a Potential Target for the Treatment of Type II Diabetes E Christiansen, C Urban, N Merten, K Liebscher, KK Karlsen, A Hamacher, ... Journal of medicinal chemistry 51 (22), 7061-7064, 2008 | 154 | 2008 |
Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation NRV Dragano, C Solon, AF Ramalho, RF de Moura, DS Razolli, ... Journal of neuroinflammation 14, 1-16, 2017 | 144 | 2017 |
Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3 BD Hudson, IG Tikhonova, SK Pandey, T Ulven, G Milligan Journal of Biological Chemistry 287 (49), 41195-41209, 2012 | 131 | 2012 |
Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3 J Schmidt, NJ Smith, E Christiansen, IG Tikhonova, M Grundmann, ... Journal of Biological Chemistry 286 (12), 10628-10640, 2011 | 129 | 2011 |
Chemical Synthesis and Biological Evaluation of cis- and trans-12,13-Cyclopropyl and 12,13-Cyclobutyl Epothilones and Related Pyridine Side Chain Analogues KC Nicolaou, K Namoto, A Ritzen, T Ulven, M Shoji, J Li, G D'Amico, ... Journal of the American Chemical Society 123 (38), 9313-9323, 2001 | 126 | 2001 |
Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases E Christiansen, KR Watterson, CJ Stocker, E Sokol, L Jenkins, K Simon, ... British Journal of Nutrition 113 (11), 1677-1688, 2015 | 122 | 2015 |
The oxygen‐mediated synthesis of 1, 3‐butadiynes in continuous flow: Using Teflon AF‐2400 to effect gas/liquid contact TP Petersen, A Polyzos, M O'Brien, T Ulven, IR Baxendale, SV Ley ChemSusChem 5 (2), 274-277, 2012 | 120 | 2012 |
Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2 JM Mathiesen, T Ulven, L Martini, LO Gerlach, A Heinemann, E Kostenis Molecular pharmacology 68 (2), 393-402, 2005 | 118 | 2005 |
Dietary fatty acids and their potential for controlling metabolic diseases through activation of FFA4/GPR120 T Ulven, E Christiansen Annual Review of Nutrition 35 (1), 239-263, 2015 | 115 | 2015 |
Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist T Ulven, E Kostenis Journal of medicinal chemistry 48 (4), 897-900, 2005 | 108 | 2005 |
A protocol for amide bond formation with electron deficient amines and sterically hindered substrates ME Due-Hansen, SK Pandey, E Christiansen, R Andersen, SVF Hansen, ... Organic & Biomolecular Chemistry 14 (2), 430-433, 2016 | 105 | 2016 |
Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor BD Hudson, ME Due-Hansen, E Christiansen, AM Hansen, AE Mackenzie, ... Journal of Biological Chemistry 288 (24), 17296-17312, 2013 | 104 | 2013 |