| Diverse role of survival motor neuron protein RN Singh, MD Howell, EW Ottesen, NN Singh Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1860 (3), 299-315, 2017 | 294 | 2017 |
| ISS-N1 makes the first FDA-approved drug for spinal muscular atrophy EW Ottesen Translational neuroscience 8 (1), 1-6, 2017 | 187 | 2017 |
| TIA1 prevents skipping of a critical exon associated with spinal muscular atrophy NN Singh, J Seo, EW Ottesen, M Shishimorova, D Bhattacharya, ... Molecular and cellular biology 31 (5), 935-954, 2011 | 104 | 2011 |
| An intronic structure enabled by a long-distance interaction serves as a novel target for splicing correction in spinal muscular atrophy NN Singh, MN Lawler, EW Ottesen, D Upreti, JR Kaczynski, RN Singh Nucleic acids research 41 (17), 8144-8165, 2013 | 96 | 2013 |
| The first orally deliverable small molecule for the treatment of spinal muscular atrophy RN Singh, EW Ottesen, NN Singh Neuroscience Insights 15, 2633105520973985, 2020 | 84 | 2020 |
| Severe impairment of male reproductive organ development in a low SMN expressing mouse model of spinal muscular atrophy EW Ottesen, MD Howell, NN Singh, J Seo, EM Whitley, RN Singh Scientific reports 6 (1), 20193, 2016 | 73 | 2016 |
| Human Survival Motor Neuron genes generate a vast repertoire of circular RNAs EW Ottesen, D Luo, J Seo, NN Singh, RN Singh Nucleic acids research 47 (6), 2884-2905, 2019 | 70 | 2019 |
| A novel human-specific splice isoform alters the critical C-terminus of Survival Motor Neuron protein J Seo, NN Singh, EW Ottesen, BM Lee, RN Singh Scientific reports 6 (1), 30778, 2016 | 62 | 2016 |
| Oxidative stress triggers body-wide skipping of multiple exons of the spinal muscular atrophy gene J Seo, NN Singh, EW Ottesen, S Sivanesan, M Shishimorova, RN Singh PloS one 11 (4), e0154390, 2016 | 53 | 2016 |
| A Multilayered Control of the Human Survival Motor Neuron Gene Expression by Alu Elements EW Ottesen, J Seo, NN Singh, RN Singh Frontiers in Microbiology 8, 2252, 2017 | 41 | 2017 |
| TIA1 is a gender-specific disease modifier of a mild mouse model of spinal muscular atrophy MD Howell, EW Ottesen, NN Singh, RL Anderson, J Seo, S Sivanesan, ... Scientific reports 7 (1), 7183, 2017 | 33 | 2017 |
| A forward genetic screen to explore chloroplast protein import in vivo identifies Moco sulfurase, pivotal for ABA and IAA biosynthesis and purine turnover R Zhong, J Thompson, E Ottesen, GK Lamppa The Plant Journal 63 (1), 44-59, 2010 | 32 | 2010 |
| Activation of a cryptic 5′ splice site reverses the impact of pathogenic splice site mutations in the spinal muscular atrophy gene NN Singh, JB Del Rio-Malewski, D Luo, EW Ottesen, MD Howell, ... Nucleic Acids Research 45 (21), 12214-12240, 2017 | 31 | 2017 |
| Gender-specific amelioration of SMA phenotype upon disruption of a deep intronic structure by an oligonucleotide MD Howell, EW Ottesen, NN Singh, RL Anderson, RN Singh Molecular Therapy 25 (6), 1328-1341, 2017 | 30 | 2017 |
| High-affinity RNA targets of the Survival Motor Neuron protein reveal diverse preferences for sequence and structural motifs EW Ottesen, NN Singh, D Luo, RN Singh Nucleic acids research 46 (20), 10983-11001, 2018 | 26 | 2018 |
| Antisense methods to modulate pre-mRNA splicing J Seo, EW Ottesen, RN Singh Spliceosomal Pre-mRNA Splicing: Methods and Protocols, 271-283, 2014 | 22 | 2014 |
| Diverse targets of SMN2-directed splicing-modulating small molecule therapeutics for spinal muscular atrophy EW Ottesen, NN Singh, D Luo, B Kaas, BJ Gillette, J Seo, HJ Jorgensen, ... Nucleic Acids Research 51 (12), 5948-5980, 2023 | 19 | 2023 |
| Characteristics of circular RNAs generated by human Survival Motor Neuron genes EW Ottesen, RN Singh Cellular signalling 73, 109696, 2020 | 19 | 2020 |
| High concentration of an ISS-N1-targeting antisense oligonucleotide causes massive perturbation of the transcriptome EW Ottesen, D Luo, NN Singh, RN Singh International Journal of Molecular Sciences 22 (16), 8378, 2021 | 16 | 2021 |
| A survey of transcripts generated by spinal muscular atrophy genes NN Singh, EW Ottesen, RN Singh Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1863 (8), 194562, 2020 | 15 | 2020 |
