| A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology H Fu, A Possenti, R Freer, Y Nakano, NC Hernandez Villegas, M Tang, ... Nature neuroscience 22 (1), 47-56, 2019 | 197 | 2019 |
| Structure-based discovery of small-molecule inhibitors of the autocatalytic proliferation of α-Synuclein aggregates S Chia, Z Faidon Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, ... Molecular Pharmaceutics 20 (1), 183-193, 2022 | 27 | 2022 |
| Exploration and exploitation approaches based on generative machine learning to identify potent small molecule inhibitors of α-synuclein secondary nucleation RI Horne, MH Murtada, D Huo, ZF Brotzakis, RC Gregory, A Possenti, ... Journal of Chemical Theory and Computation 19 (14), 4701-4710, 2023 | 14 | 2023 |
| Using generative modeling to endow with potency initially inert compounds with good bioavailability and low toxicity RI Horne, J Wilson-Godber, A González Díaz, ZF Brotzakis, S Seal, ... Journal of Chemical Information and Modeling 64 (3), 590-596, 2024 | 7 | 2024 |
| A machine learning approach to identify small molecule inhibitors of secondary nucleation in α-synuclein aggregation R Horne, A Possenti, S Chia, ZF Brotzakis, R Staats, M Nowinska, ... | 6 | 2022 |
| A method for partitioning the information contained in a protein sequence between its structure and function A Possenti, M Vendruscolo, C Camilloni, G Tiana Proteins: Structure, Function, and Bioinformatics 86 (9), 956-964, 2018 | 6 | 2018 |
| Discovery of potent inhibitors of α-Synuclein aggregation using structure-based iterative learning RI Horne, E Andrzejewska, P Alam, ZF Brotzakis, A Srivastava, A Aubert, ... bioRxiv, 2021.11. 10.468009, 2021 | 4 | 2021 |
| A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions S Chia, RL Cataldi, FS Ruggeri, R Limbocker, I Condado-Morales, ... ACS Chemical Neuroscience 15 (6), 1125-1134, 2024 | 1 | 2024 |
| Therapy for protein misfolding disease J Habchi, Y Xiaoting, K Jenkins, M Perni, S Sarwat, J Menzies, ... US Patent App. 17/045,075, 2021 | 1 | 2021 |
| In situ generation of Aβ42 oligomers via secondary nucleation triggers neurite degeneration and synaptic dysfunction in human iPSC-derived glutamatergic neurons AG Díaz, E Sarracco, A Possenti, I Kitchen-Smith, S Chia, J Menzies, ... bioRxiv, 2024.08. 30.610591, 2024 | | 2024 |
| A human neuronal model of sporadic Alzheimer's disease induced by FBXO2 downregulation shows A β aggregation, tau hyperphosphorylation and functional network impairment A Gonzalez-Diaz, A Possenti, GA Urrutia, Y Bian, S Kedia, D Boeken, ... bioRxiv, 2024.09. 01.610673, 2024 | | 2024 |
| Transcriptomic studies of protein homeostasis perturbations in neurodegenerative disorders A Possenti | | 2021 |
| Therapy for ophthalmological conditions MV Johnny Habchi, Xiaoting Yang, Kerry Jenkins, Michele Perni, Sunehera ... US Patent App. 17/045,119, 2021 | | 2021 |
| O2‐01‐04: CELL TYPE–SPECIFIC TAU HOMEOSTASIS SIGNATURES ASSOCIATED WITH SELECTIVE VULNERABILITY OF EXCITATORY NEURONS TO TAU PATHOLOGY H Fu, A Possenti, R Freer, Y Nakano, NE Hernandez Villegas, ... Alzheimer's & Dementia 14 (7S_Part_11), P609-P609, 2018 | | 2018 |
| Using machine learning to endow with potency initially inert compounds with good bioavailability and low toxicity RI Horne, J Wilson-Godber, AG Díaz, ZF Brotzakis, S Seal, RC Gregory, ... | | |
Michele VendruscoloProfessor of Biophysics, University of Cambridge在 cam.ac.uk 的电子邮件经过验证
