| PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells A Boire, L Covic, A Agarwal, S Jacques, S Sherifi, A Kuliopulos Cell 120 (3), 303-313, 2005 | 1038 | 2005 |
| Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides L Covic, AL Gresser, J Talavera, S Swift, A Kuliopulos Proceedings of the National Academy of Sciences 99 (2), 643-648, 2002 | 432 | 2002 |
| Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets L Covic, AL Gresser, A Kuliopulos Biochemistry 39 (18), 5458-5467, 2000 | 366 | 2000 |
| Protease-activated receptors in cardiovascular diseases AJ Leger, L Covic, A Kuliopulos Circulation 114 (10), 1070-1077, 2006 | 359 | 2006 |
| Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation L Covic, M Misra, J Badar, C Singh, A Kuliopulos Nature medicine 8 (10), 1161-1165, 2002 | 344 | 2002 |
| Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site V Trivedi, A Boire, B Tchernychev, NC Kaneider, AJ Leger, K O'Callaghan, ... Cell 137 (2), 332-343, 2009 | 277 | 2009 |
| 'Role reversal'for the receptor PAR1 in sepsis-induced vascular damage NC Kaneider, AJ Leger, A Agarwal, N Nguyen, G Perides, C Derian, ... Nature immunology 8 (12), 1303-1312, 2007 | 277 | 2007 |
| Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis AJ Leger, SL Jacques, J Badar, NC Kaneider, CK Derian, ... Circulation 113 (9), 1244-1254, 2006 | 267 | 2006 |
| Plasmin desensitization of the PAR1 thrombin receptor: kinetics, sites of truncation, and implications for thrombolytic therapy A Kuliopulos, L Covic, SK Seeley, PJ Sheridan, J Helin, CE Costello Biochemistry 38 (14), 4572-4585, 1999 | 266 | 1999 |
| Matrix metalloproteases and PAR1 activation KM Austin, L Covic, A Kuliopulos Blood, The Journal of the American Society of Hematology 121 (3), 431-439, 2013 | 207 | 2013 |
| Turning receptors on and off with intracellular pepducins: new insights into G-protein-coupled receptor drug development K O'Callaghan, A Kuliopulos, L Covic Journal of Biological Chemistry 287 (16), 12787-12796, 2012 | 187 | 2012 |
| Blockade of PAR1 signaling with cell-penetrating pepducins inhibits Akt survival pathways in breast cancer cells and suppresses tumor survival and metastasis E Yang, A Boire, A Agarwal, N Nguyen, K O'Callaghan, P Tu, A Kuliopulos, ... Cancer research 69 (15), 6223-6231, 2009 | 181 | 2009 |
| A matrix metalloprotease‐PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis SL Tressel, NC Kaneider, S Kasuda, C Foley, G Koukos, K Austin, ... EMBO molecular medicine 3 (7), 370-384, 2011 | 143 | 2011 |
| Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins LM Sevigny, P Zhang, A Bohm, K Lazarides, G Perides, L Covic, ... Proceedings of the National Academy of Sciences 108 (20), 8491-8496, 2011 | 139 | 2011 |
| Identification of a metalloprotease-chemokine signaling system in the ovarian cancer microenvironment: implications for antiangiogenic therapy A Agarwal, SL Tressel, R Kaimal, M Balla, FH Lam, L Covic, A Kuliopulos Cancer research 70 (14), 5880-5890, 2010 | 137 | 2010 |
| Targeting a metalloprotease-PAR1 signaling system with cell-penetrating pepducins inhibits angiogenesis, ascites, and progression of ovarian cancer A Agarwal, L Covic, LM Sevigny, NC Kaneider, K Lazarides, ... Molecular cancer therapeutics 7 (9), 2746-2757, 2008 | 130 | 2008 |
| Cell-penetrating pepducin therapy targeting PAR1 in subjects with coronary artery disease PA Gurbel, KP Bliden, SE Turner, US Tantry, MG Gesheff, TP Barr, ... Arteriosclerosis, thrombosis, and vascular biology 36 (1), 189-197, 2016 | 121 | 2016 |
| Pharmacology, biodistribution, and efficacy of GPCR-based pepducins in disease models SL Tressel, G Koukos, B Tchernychev, SL Jacques, L Covic, A Kuliopulos Cell-Penetrating Peptides: Methods and Protocols, 259-275, 2011 | 114 | 2011 |
| Targeting protease-activated receptor-1 with cell-penetrating pepducins in lung cancer J Cisowski, K O'Callaghan, A Kuliopulos, J Yang, N Nguyen, Q Deng, ... The American journal of pathology 179 (1), 513-523, 2011 | 113 | 2011 |
| Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome L Covic, C Singh, H Smith, A Kuliopulos Thrombosis and haemostasis 87 (04), 722-727, 2002 | 106 | 2002 |
