NAD+ cleavage activity by animal and plant TIR domains in cell death pathways S Horsefield, H Burdett, X Zhang, MK Manik, Y Shi, J Chen, T Qi, J Gilley, ... Science 365 (6455), 793-799, 2019 | 420 | 2019 |
Structural and functional analysis of a plant resistance protein TIR domain reveals interfaces for self-association, signaling, and autoregulation M Bernoux, T Ve, S Williams, C Warren, D Hatters, E Valkov, X Zhang, ... Cell host & microbe 9 (3), 200-211, 2011 | 398 | 2011 |
Structural basis for assembly and function of a heterodimeric plant immune receptor SJ Williams, KH Sohn, L Wan, M Bernoux, PF Sarris, C Segonzac, T Ve, ... Science 344 (6181), 299-303, 2014 | 374 | 2014 |
Megahertz serial crystallography MO Wiedorn, D Oberthür, R Bean, R Schubert, N Werner, B Abbey, ... Nature communications 9 (1), 4025, 2018 | 222 | 2018 |
SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration MD Figley, W Gu, JD Nanson, Y Shi, Y Sasaki, K Cunnea, AK Malde, X Jia, ... Neuron 109 (7), 1118-1136. e11, 2021 | 213 | 2021 |
The AvrM effector from flax rust has a structured C-terminal domain and interacts directly with the M resistance protein AM Catanzariti, PN Dodds, T Ve, B Kobe, JG Ellis, BJ Staskawicz Molecular Plant-Microbe Interactions 23 (1), 49-57, 2010 | 170 | 2010 |
Structural basis of TIR-domain-assembly formation in MAL-and MyD88-dependent TLR4 signaling T Ve, PR Vajjhala, A Hedger, T Croll, F DiMaio, S Horsefield, X Yu, ... Nature structural & molecular biology 24 (9), 743-751, 2017 | 164 | 2017 |
Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains T Ve, SJ Williams, B Kobe Apoptosis 20, 250-261, 2015 | 163 | 2015 |
Multiple functional self-association interfaces in plant TIR domains X Zhang, M Bernoux, AR Bentham, TE Newman, T Ve, LW Casey, ... Proceedings of the National Academy of Sciences 114 (10), E2046-E2052, 2017 | 140 | 2017 |
Intramolecular interaction influences binding of the Flax L5 and L6 resistance proteins to their AvrL567 ligands M Ravensdale, M Bernoux, T Ve, B Kobe, PH Thrall, JG Ellis, PN Dodds PLoS pathogens 8 (11), e1003004, 2012 | 122 | 2012 |
The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways PR Vajjhala, T Ve, A Bentham, KJ Stacey, B Kobe Molecular immunology 86, 23-37, 2017 | 107 | 2017 |
Adaptors in toll-like receptor signaling and their potential as therapeutic targets T Ve, N J Gay, A Mansell, B Kobe, S Kellie Current drug targets 13 (11), 1360-1374, 2012 | 98 | 2012 |
Structures of the flax-rust effector AvrM reveal insights into the molecular basis of plant-cell entry and effector-triggered immunity T Ve, SJ Williams, AM Catanzariti, M Rafiqi, M Rahman, JG Ellis, ... Proceedings of the National Academy of Sciences 110 (43), 17594-17599, 2013 | 89 | 2013 |
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules Y Shi, PS Kerry, JD Nanson, T Bosanac, Y Sasaki, R Krauss, FK Saikot, ... Molecular cell 82 (9), 1643-1659. e10, 2022 | 78 | 2022 |
Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB M Alaidarous, T Ve, LW Casey, E Valkov, DJ Ericsson, MO Ullah, ... Journal of Biological Chemistry 289 (2), 654-668, 2014 | 78 | 2014 |
Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling MK Manik, Y Shi, S Li, MA Zaydman, N Damaraju, S Eastman, TG Smith, ... Science 377 (6614), eadc8969, 2022 | 75 | 2022 |
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography MTB Clabbers, S Holmes, TW Muusse, PR Vajjhala, SJ Thygesen, ... Nature communications 12 (1), 2578, 2021 | 74 | 2021 |
Towards the structure of the TIR-domain signalosome S Nimma, T Ve, SJ Williams, B Kobe Current opinion in structural biology 43, 122-130, 2017 | 70 | 2017 |
An oxidized tryptophan facilitates copper binding in Methylococcus capsulatus-secreted protein MopE R Helland, A Fjellbirkeland, OA Karlsen, T Ve, JR Lillehaug, HB Jensen Journal of Biological Chemistry 283 (20), 13897-13904, 2008 | 60 | 2008 |
The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4 B Verstak, J Stack, T Ve, M Mangan, K Hjerrild, J Jeon, R Stahl, E Latz, ... Journal of leukocyte biology 96 (3), 427-436, 2014 | 59 | 2014 |