The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor ζ-chain and induce a regulatory phenotype in naive T cells F Fallarino, U Grohmann, S You, BC McGrath, DR Cavener, C Vacca, ... The Journal of Immunology 176 (11), 6752-6761, 2006 | 1285 | 2006 |
Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates DR Cavener Nucleic acids research 15 (4), 1353-1361, 1987 | 1178 | 1987 |
Eukaryotic start and stop translation sites DR Cavener, SC Ray Nucleic acids research 19 (12), 3185-3192, 1991 | 726 | 1991 |
The PERK eukaryotic initiation factor 2α kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas P Zhang, B McGrath, A Frank, F Zambito, J Reinert, M Gannon, K Ma, ... Molecular and cellular biology, 2002 | 716 | 2002 |
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response HY Jiang, SA Wek, BC McGrath, D Lu, T Hai, HP Harding, X Wang, D Ron, ... Molecular and cellular biology 24 (3), 1365-1377, 2004 | 609 | 2004 |
Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits T Ma, MA Trinh, AJ Wexler, C Bourbon, E Gatti, P Pierre, DR Cavener, ... Nature neuroscience 16 (9), 1299-1305, 2013 | 574 | 2013 |
The GCN2 eIF2α kinase is required for adaptation to amino acid deprivation in mice P Zhang, BC McGrath, J Reinert, DAS Olsen, L Lei, S Gill, SA Wek, ... Molecular and cellular biology 22 (19), 6681-6688, 2002 | 544 | 2002 |
Phosphorylation of the α subunit of eukaryotic initiation factor 2 is required for activation of NF-κB in response to diverse cellular stresses HY Jiang, SA Wek, BC McGrath, D Scheuner, RJ Kaufman, DR Cavener, ... Molecular and cellular biology 23 (16), 5651-5663, 2003 | 529 | 2003 |
Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism V Senée, C Chelala, S Duchatelet, D Feng, H Blanc, JC Cossec, ... Nature genetics 38 (6), 682-687, 2006 | 405 | 2006 |
Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex S Hao, JW Sharp, CM Ross-Inta, BJ McDaniel, TG Anthony, RC Wek, ... Science 307 (5716), 1776-1778, 2005 | 383 | 2005 |
A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2α R Sood, AC Porter, DA Olsen, DR Cavener, RC Wek Genetics 154 (2), 787-801, 2000 | 363 | 2000 |
PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage E Bobrovnikova-Marjon, C Grigoriadou, D Pytel, F Zhang, J Ye, ... Oncogene 29 (27), 3881-3895, 2010 | 360 | 2010 |
GMC oxidoreductases: a newly defined family of homologous proteins with diverse catalytic activities DR Cavener Journal of molecular biology 223 (3), 811-814, 1992 | 360 | 1992 |
Translational control and the unfolded protein response RC Wek, DR Cavener Antioxidants & redox signaling 9 (12), 2357-2372, 2007 | 359 | 2007 |
PERK EIF2AK3 control of pancreatic β cell differentiation and proliferation is required for postnatal glucose homeostasis W Zhang, D Feng, Y Li, K Iida, B McGrath, DR Cavener Cell metabolism 4 (6), 491-497, 2006 | 343 | 2006 |
Analysis of the PvuII Restriction Fragment-length Polymorphism and Exon Structure of the Estrogen Receptor Gene in Breast Cancer and Peripheral Blood L Yaich, WD Dupont, DR Cavener, FF Parl Cancer research 52 (1), 77-83, 1992 | 336 | 1992 |
The GCN2 eIF2α kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid F Guo, DR Cavener Cell metabolism 5 (2), 103-114, 2007 | 333 | 2007 |
Endoplasmic reticulum stress response mediated by the PERK-eIF2α-ATF4 pathway is involved in osteoblast differentiation induced by BMP2 A Saito, K Ochiai, S Kondo, K Tsumagari, T Murakami, DR Cavener, ... Journal of biological chemistry 286 (6), 4809-4818, 2011 | 314 | 2011 |
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation E Bobrovnikova-Marjon, G Hatzivassiliou, C Grigoriadou, M Romero, ... Proceedings of the National Academy of Sciences 105 (42), 16314-16319, 2008 | 284 | 2008 |
Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2 TG Anthony, BJ McDaniel, RL Byerley, BC McGrath, DR Cavener, ... Journal of Biological Chemistry 279 (35), 36553-36561, 2004 | 270 | 2004 |