Expanding small-molecule functional metagenomics through parallel screening of broad-host-range cosmid environmental DNA libraries in diverse proteobacteria JW Craig, FY Chang, JH Kim, SC Obiajulu, SF Brady Applied and environmental microbiology 76 (5), 1633-1641, 2010 | 263 | 2010 |
Discovery of reactive microbiota-derived metabolites that inhibit host proteases CJ Guo, FY Chang, TP Wyche, KM Backus, TM Acker, M Funabashi, ... Cell 168 (3), 517-526. e18, 2017 | 216 | 2017 |
A pressure test to make 10 molecules in 90 days: external evaluation of methods to engineer biology A Casini, FY Chang, R Eluere, AM King, EM Young, QM Dudley, A Karim, ... Journal of the American Chemical Society 140 (12), 4302-4316, 2018 | 152 | 2018 |
Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening FY Chang, SF Brady Proceedings of the National Academy of Sciences 110 (7), 2478-2483, 2013 | 124 | 2013 |
Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters D Montiel, HS Kang, FY Chang, Z Charlop-Powers, SF Brady Proceedings of the National Academy of Sciences 112 (29), 8953-8958, 2015 | 122 | 2015 |
Cloning and characterization of an environmental DNA-derived gene cluster that encodes the biosynthesis of the antitumor substance BE-54017 FY Chang, SF Brady Journal of the American Chemical Society 133 (26), 9996-9999, 2011 | 97 | 2011 |
Natural Products from Environmental DNA Hosted in Ralstonia metallidurans JW Craig, FY Chang, SF Brady ACS chemical biology 4 (1), 23-28, 2009 | 97 | 2009 |
Targeted metagenomics: finding rare tryptophan dimer natural products in the environment FY Chang, MA Ternei, PY Calle, SF Brady Journal of the American Chemical Society 137 (18), 6044-6052, 2015 | 58 | 2015 |
Discovery and synthetic refactoring of tryptophan dimer gene clusters from the environment FY Chang, MA Ternei, PY Calle, SF Brady Journal of the American Chemical Society 135 (47), 17906-17912, 2013 | 53 | 2013 |
Gut-inhabiting Clostridia build human GPCR ligands by conjugating neurotransmitters with diet-and human-derived fatty acids FY Chang, P Siuti, S Laurent, T Williams, E Glassey, AW Sailer, ... Nature microbiology 6 (6), 792-805, 2021 | 41 | 2021 |
Characterization of an Environmental DNA‐Derived Gene Cluster that Encodes the Bisindolylmaleimide Methylarcyriarubin FY Chang, SF Brady ChemBioChem 15 (6), 815-821, 2014 | 26 | 2014 |
Mutations in the Proteolipid Subunits of the Vacuolar H+-ATPase Provide Resistance to Indolotryptoline Natural Products FY Chang, SA Kawashima, SF Brady Biochemistry 53 (45), 7123-7131, 2014 | 10 | 2014 |
Direct Preparation of Indole Hemiaminals through Organocatalytic Nucleophilic Addition of Indole to Aldehydes N Zhang, Y Li, Z Chen, W Qin Synthesis 50 (20), 4063-4070, 2018 | 4 | 2018 |
Human gut microbiome-derived biosynthetic enzymes for production of fatty acid amides CA Voigt, FY Chang US Patent App. 17/812,156, 2023 | | 2023 |
Human gut microbiome-derived biosynthetic enzymes for production of fatty acid amides CA Voigt, FY Chang US Patent 11,441,162, 2022 | | 2022 |
Compositions and methods for modulating protease activity MA Fischbach, CJ Guo, CA Voigt, FY Chang, J Clardy, T Wyche US Patent 11,124,498, 2021 | | 2021 |
Metagenomics-Based Tryptophan Dimer Natural Product Discovery and Development Pipeline FY Chang | | 2015 |
Introducing our Authors T Buchholz, FY Chang, J Craig, T Dasgupta, N Homeyer, H Jenssen, ... ACS Chemical Biology 4 (1), 4-6, 2009 | | 2009 |
Sean F Brady FY Chang J Am Chem Soc 133 (26), 9996-9999, 0 | | |