Controlled Oxidation of Remote sp3 C–H Bonds in Artemisinin via P450 Catalysts with Fine-Tuned Regio- and Stereoselectivity K Zhang, BM Shafer, MD Demars, HA Stern, R Fasan Journal of the American Chemical Society 134 (45), 18695-18704, 2012 | 203 | 2012 |
Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C H Functionalization AN Lowell, MD DeMars, ST Slocum, F Yu, K Anand, JA Chemler, ... Journal of the American Chemical Society 139 (23), 7913-7920, 2017 | 83 | 2017 |
Regiodivergent glycosylations of 6-deoxy-erythronolide B and oleandomycin-derived macrolactones enabled by chiral acid catalysis JH Tay, AJ Argüelles, MD DeMars, PM Zimmerman, DH Sherman, ... Journal of the American Chemical Society 139 (25), 8570-8578, 2017 | 72* | 2017 |
Synthesis of diverse 11-and 12-membered macrolactones from a common linear substrate using a single biocatalyst MM Gilbert, MD DeMars, S Yang, JM Grandner, S Wang, H Wang, ... ACS Central Science 3 (12), 1304-1310, 2017 | 26 | 2017 |
Computational-based mechanistic study and engineering of cytochrome P450 MycG for selective oxidation of 16-membered macrolide antibiotics S Yang, MD DeMars, JM Grandner, NM Olson, Y Anzai, DH Sherman, ... Journal of the American Chemical Society 142 (42), 17981-17988, 2020 | 19 | 2020 |
Biochemical and structural characterization of MycCI, a versatile P450 biocatalyst from the mycinamicin biosynthetic pathway MD DeMars, F Sheng, SR Park, AN Lowell, LM Podust, DH Sherman ACS chemical biology 11 (9), 2642-2654, 2016 | 16 | 2016 |
Recycling upstream redox enzymes expands the regioselectivity of cycloaddition in pseudo-aspidosperma alkaloid biosynthesis MO Kamileen, MD DeMars, B Hong, Y Nakamura, C Paetz, BR Lichman, ... Journal of the American Chemical Society 144 (43), 19673-19679, 2022 | 9 | 2022 |
Exploring the molecular basis for substrate specificity in homologous macrolide biosynthetic cytochromes P450 MD DeMars, NL Samora, S Yang, M Garcia-Borràs, JN Sanders, KN Houk, ... Journal of Biological Chemistry 294 (44), 15947-15961, 2019 | 7 | 2019 |
Structure and biochemistry of cytochromes P450 involved in the biosynthesis of macrolide antibiotics M DeMars II | 3 | 2017 |
Evolution and diversification of carboxylesterase-like [4+ 2] cyclases in aspidosperma and iboga alkaloid biosynthesis MD DeMars, SE O’Connor Proceedings of the National Academy of Sciences 121 (7), e2318586121, 2024 | 1 | 2024 |
Mechanism and Evolution of [4+ 2] Cyclases in Monoterpene Indole Alkaloid Biosynthesis MD DeMars, Y Nakamura, MO Kamileen, JN Sanders, C Paetz, KN Houk, ... The FASEB Journal 36, 2022 | | 2022 |
Comparative Analysis of Bacterial Cytochromes P450 Involved in the Biosynthesis of 16‐Membered Ring Macrolide Antibiotics MD DeMars, S Yang, F Sheng, NL Samora, SR Park, AN Lowell, KN Houk, ... The FASEB Journal 32, 529.4-529.4, 2018 | | 2018 |
Synthesis of Diverse 11-and 12-Membered Macrolactones from a Common Linear Substrate MM Gilbert, MD DeMars, S Yang ACS central science, 3 (12), 2017 | | 2017 |
Exploring biosynthetic P450s as biocatalysts for multi-functional CH oxidation J Stachowski, M Demars, D Sherman, J Montgomery ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 254, 2017 | | 2017 |
Studying the substrate specificity and reactivity of MycG: A multifunctional enzyme S Yang, J Grandner, M Demars, D Sherman, K Houk ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 253, 2017 | | 2017 |
Chemoenzymatic methods in the total synthesis of macrolide antibiotics: The 16-membered macrolactone core of tylosin/rosamicin/juvenimicin A Lowell, S Slocum, A Koch, M DeMars, N Korakavi, J Chemler, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 252, 2016 | | 2016 |