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Christopher L. Shaffer
Christopher L. Shaffer
在 biogen.com 的电子邮件经过验证
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A comprehensive listing of bioactivation pathways of organic functional groups
AS Kalgutkar, I Gardner, RS Obach, CL Shaffer, E Callegari, KR Henne, ...
Current drug metabolism 6 (3), 161-225, 2005
7002005
Analytical strategies for identifying drug metabolites
C Prakash, CL Shaffer, A Nedderman
Mass spectrometry reviews 26 (3), 340-369, 2007
3682007
Partial agonists of the α3β4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats
S Chatterjee, P Steensland, JA Simms, J Holgate, JW Coe, RS Hurst, ...
Neuropsychopharmacology 36 (3), 603-615, 2011
1182011
Formation of cyclopropanone during cytochrome P450-catalyzed N-dealkylation of a cyclopropylamine
CL Shaffer, S Harriman, YM Koen, RP Hanzlik
Journal of the American Chemical Society 124 (28), 8268-8274, 2002
962002
N-Dealkylation of an N-Cyclopropylamine by Horseradish Peroxidase. Fate of the Cyclopropyl Group
CL Shaffer, MD Morton, RP Hanzlik
Journal of the American Chemical Society 123 (35), 8502-8508, 2001
912001
Discovery of trifluoromethyl glycol carbamates as potent and selective covalent monoacylglycerol lipase (MAGL) inhibitors for treatment of neuroinflammation
LA McAllister, CR Butler, S Mente, SV O’Neil, KR Fonseca, JR Piro, ...
Journal of medicinal chemistry 61 (7), 3008-3026, 2018
752018
The ELFIN mission
V Angelopoulos, E Tsai, L Bingley, C Shaffer, DL Turner, A Runov, W Li, ...
Space science reviews 216, 1-45, 2020
742020
Phosphodiesterase type 5 (PDE5) inhibition improves object recognition memory: indications for central and peripheral mechanisms
OAH Reneerkens, K Rutten, S Akkerman, A Blokland, CL Shaffer, ...
Neurobiology of learning and memory 97 (4), 370-379, 2012
722012
Glycine transporter inhibition reverses ketamine-induced working memory deficits
BM Roberts, CL Shaffer, PA Seymour, CJ Schmidt, GV Williams, ...
Neuroreport 21 (5), 390-394, 2010
612010
Discovery and Preclinical Characterization of 1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): A Highly Potent …
L Zhang, G Balan, G Barreiro, BP Boscoe, LK Chenard, J Cianfrogna, ...
Journal of medicinal chemistry 57 (3), 861-877, 2014
582014
A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4 …
AS Kalgutkar, J Driscoll, SX Zhao, GS Walker, RM Shepard, JR Soglia, ...
Chemical research in toxicology 20 (12), 1954-1965, 2007
562007
Enhancing ketamine translational pharmacology via receptor occupancy normalization
CL Shaffer, SM Osgood, DL Smith, JH Liu, PE Trapa
Neuropharmacology 86, 174-180, 2014
552014
Strategies to optimize the brain availability of central nervous system drug candidates
TT Wager, A Villalobos, PR Verhoest, X Hou, CL Shaffer
Expert Opinion on Drug Discovery 6 (4), 371-381, 2011
552011
Defining neuropharmacokinetic parameters in CNS drug discovery to determine cross-species pharmacologic exposure–response relationships
CL Shaffer
Annual Reports in Medicinal Chemistry 45, 55-70, 2010
542010
Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction
BM Roberts, DE Holden, CL Shaffer, PA Seymour, FS Menniti, CJ Schmidt, ...
Behavioural brain research 212 (1), 41-48, 2010
492010
Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development
I Loryan, A Reichel, B Feng, C Bundgaard, C Shaffer, C Kalvass, ...
Pharmaceutical research 39 (7), 1321-1341, 2022
442022
Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574
CL Shaffer, RS Hurst, RJ Scialis, SM Osgood, DK Bryce, WE Hoffmann, ...
Journal of Pharmacology and Experimental Therapeutics 347 (1), 212-224, 2013
442013
Attenuation of ketamine-induced impairment in verbal learning and memory in healthy volunteers by the AMPA receptor potentiator PF-04958242
M Ranganathan, N DeMartinis, B Huguenel, F Gaudreault, MM Bednar, ...
Molecular psychiatry 22 (11), 1633-1640, 2017
432017
An evaluation of using rat-derived single-dose neuropharmacokinetic parameters to project accurately large animal unbound brain drug concentrations
AC Doran, SM Osgood, JY Mancuso, CL Shaffer
Drug metabolism and disposition 40 (11), 2162-2173, 2012
432012
Enzymatic N-Dealkylation of an N-Cyclopropylamine:  An Unusual Fate for the Cyclopropyl Group
CL Shaffer, MD Morton, RP Hanzlik
Journal of the American Chemical Society 123 (2), 349-350, 2001
432001
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