The cyclic nucleotide–binding homology domain of the integral membrane protein CNNM mediates dimerization and is required for Mg2+ efflux activity YS Chen, G Kozlov, R Fakih, Y Funato, H Miki, K Gehring Journal of biological chemistry 293 (52), 19998-20007, 2018 | 47 | 2018 |
Mg2+-ATP sensing in CNNM, a putative magnesium transporter YS Chen, G Kozlov, R Fakih, M Yang, Z Zhang, EL Kovrigin, K Gehring Structure 28 (3), 324-335. e4, 2020 | 41 | 2020 |
Crystal structure of an archaeal CorB magnesium transporter YS Chen, G Kozlov, BE Moeller, A Rohaim, R Fakih, B Roux, JE Burke, ... Nature communications 12 (1), 4028, 2021 | 36 | 2021 |
PRL3 pseudophosphatase activity is necessary and sufficient to promote metastatic growth G Kozlov, Y Funato, YS Chen, Z Zhang, K Illes, H Miki, K Gehring Journal of Biological Chemistry 295 (33), 11682-11692, 2020 | 35 | 2020 |
Mechanism of thienopyridone and iminothienopyridinedione inhibition of protein phosphatases Z Zhang, G Kozlov, YS Chen, K Gehring MedChemComm 10 (5), 791-799, 2019 | 16 | 2019 |
Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation O Haji-Ghassemi, YS Chen, K Woll, GB Gurrola, CR Valdivia, W Cai, S Li, ... Science Advances 9 (21), eadf4936, 2023 | 5 | 2023 |
Loss of PABPC1 is compensated by elevated PABPC4 and correlates with transcriptome changes J Xie, X Wei, Y Chen, K Gehring BioRxiv, 2021.02. 07.430165, 2021 | 5 | 2021 |
Cryo-electron microscopy structures of ArnA, a key enzyme for polymyxin resistance, revealed unexpected oligomerizations and domain movements M Yang, YS Chen, M Ichikawa, D Calles-Garcia, K Basu, R Fakih, KH Bui, ... Journal of structural biology 208 (1), 43-50, 2019 | 5 | 2019 |
RYR-1-Related Diseases International Research Workshop: From Mechanisms to Treatments Pittsburgh, PA, USA, 21–22 July 2022 TN O’Connor, LR van den Bersselaar, YS Chen, S Nicolau, B Simon, ... Journal of neuromuscular diseases 10 (1), 135, 2023 | 4 | 2023 |
New insights into the structure and function of CNNM proteins YS Chen, K Gehring The FEBS Journal 290 (23), 5475-5495, 2023 | 3 | 2023 |
Structural and functional conservation of the activating Ca2+ binding site in inositol 1, 4.5-trisphosphate and ryanodine receptors YS Chen, F Van Petegem Cell Calcium 108, 102671, 2022 | 2 | 2022 |
Structural studies of magnesium transporter CNNM Y Chen, M Yang, R Fakih, G Kozlov, K Gehring Biophysical Journal 114 (3), 570a, 2018 | 1 | 2018 |
Cryo-EM analysis of the malignant hyperthermia-causing T4826I mutant of ryanodine receptor 1 and its interplay with pharmacological agents YS Chen, M García-Castañeda, PD Allen, F Van Petegem Biophysical Journal 123 (3), 443a, 2024 | | 2024 |
Localising elements in single-particle reconstructions by REEL-EM: Reconstructed Electron Energy-Loss-Elemental Mapping O Pfeil-Gardiner, HVD Rosa, D Riedel, YS Chen, D Lorks, P Kukelhan, ... bioRxiv, 2024.01. 18.575858, 2024 | | 2024 |
Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1) TT Joseph, W Bu, O Haji-Ghassemi, YS Chen, K Woll, PD Allen, ... bioRxiv, 2024.01. 10.575040, 2024 | | 2024 |
Cryo-EM investigation of the subconductance state of ryanodine receptor calcium release channels induced by scorpion toxins F Van Petegem, O Haji-Ghassemi, Y Chen, K Woll, CR Valdivia, ... Biophysical Journal 122 (3), 164a, 2023 | | 2023 |
Cryo-EM studies of ryanodine receptor disease mutant and modulation by calmodulin YS Chen, KA Woll, O Haji-Ghassemi, F Van Petegem Biophysical Journal 121 (3), 175a, 2022 | | 2022 |
Poly (A) binding protein is required for mRNP remodeling to form P-bodies in mammalian cells J Xie, Y Chen, X Wei, G Kozlov, K Gehring bioRxiv, 2021.02. 07.430159, 2021 | | 2021 |
Paip2 associates with PABPC1 on mRNA, and may facilitate PABPC1 dissociation from mRNA upon deadenylation J Xie, X Wei, G Kozlov, Y Chen, M Menade, K Gehring bioRxiv, 2021.02. 07.430161, 2021 | | 2021 |
THE CYCLIC NUCLEOTIDEBINDING HOMOLOGY DOMAIN OF THE INTEGRAL MEMBRANE PROTEIN CNNM MEDIATES DIMERIZATION AND IS REQUIRED FOR MG2+ EFFLUX ACTIVITY YS Chen, G Kozlov, R Fakih, Y Funato, H Miki, K Gehring PROTEIN SCIENCE 28, 83-83, 2019 | | 2019 |