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Yu Seby Chen
Yu Seby Chen
在 ubc.ca 的电子邮件经过验证
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The cyclic nucleotide–binding homology domain of the integral membrane protein CNNM mediates dimerization and is required for Mg2+ efflux activity
YS Chen, G Kozlov, R Fakih, Y Funato, H Miki, K Gehring
Journal of biological chemistry 293 (52), 19998-20007, 2018
472018
Mg2+-ATP sensing in CNNM, a putative magnesium transporter
YS Chen, G Kozlov, R Fakih, M Yang, Z Zhang, EL Kovrigin, K Gehring
Structure 28 (3), 324-335. e4, 2020
412020
Crystal structure of an archaeal CorB magnesium transporter
YS Chen, G Kozlov, BE Moeller, A Rohaim, R Fakih, B Roux, JE Burke, ...
Nature communications 12 (1), 4028, 2021
362021
PRL3 pseudophosphatase activity is necessary and sufficient to promote metastatic growth
G Kozlov, Y Funato, YS Chen, Z Zhang, K Illes, H Miki, K Gehring
Journal of Biological Chemistry 295 (33), 11682-11692, 2020
352020
Mechanism of thienopyridone and iminothienopyridinedione inhibition of protein phosphatases
Z Zhang, G Kozlov, YS Chen, K Gehring
MedChemComm 10 (5), 791-799, 2019
162019
Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation
O Haji-Ghassemi, YS Chen, K Woll, GB Gurrola, CR Valdivia, W Cai, S Li, ...
Science Advances 9 (21), eadf4936, 2023
52023
Loss of PABPC1 is compensated by elevated PABPC4 and correlates with transcriptome changes
J Xie, X Wei, Y Chen, K Gehring
BioRxiv, 2021.02. 07.430165, 2021
52021
Cryo-electron microscopy structures of ArnA, a key enzyme for polymyxin resistance, revealed unexpected oligomerizations and domain movements
M Yang, YS Chen, M Ichikawa, D Calles-Garcia, K Basu, R Fakih, KH Bui, ...
Journal of structural biology 208 (1), 43-50, 2019
52019
RYR-1-Related Diseases International Research Workshop: From Mechanisms to Treatments Pittsburgh, PA, USA, 21–22 July 2022
TN O’Connor, LR van den Bersselaar, YS Chen, S Nicolau, B Simon, ...
Journal of neuromuscular diseases 10 (1), 135, 2023
42023
New insights into the structure and function of CNNM proteins
YS Chen, K Gehring
The FEBS Journal 290 (23), 5475-5495, 2023
32023
Structural and functional conservation of the activating Ca2+ binding site in inositol 1, 4.5-trisphosphate and ryanodine receptors
YS Chen, F Van Petegem
Cell Calcium 108, 102671, 2022
22022
Structural studies of magnesium transporter CNNM
Y Chen, M Yang, R Fakih, G Kozlov, K Gehring
Biophysical Journal 114 (3), 570a, 2018
12018
Cryo-EM analysis of the malignant hyperthermia-causing T4826I mutant of ryanodine receptor 1 and its interplay with pharmacological agents
YS Chen, M García-Castañeda, PD Allen, F Van Petegem
Biophysical Journal 123 (3), 443a, 2024
2024
Localising elements in single-particle reconstructions by REEL-EM: Reconstructed Electron Energy-Loss-Elemental Mapping
O Pfeil-Gardiner, HVD Rosa, D Riedel, YS Chen, D Lorks, P Kukelhan, ...
bioRxiv, 2024.01. 18.575858, 2024
2024
Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1)
TT Joseph, W Bu, O Haji-Ghassemi, YS Chen, K Woll, PD Allen, ...
bioRxiv, 2024.01. 10.575040, 2024
2024
Cryo-EM investigation of the subconductance state of ryanodine receptor calcium release channels induced by scorpion toxins
F Van Petegem, O Haji-Ghassemi, Y Chen, K Woll, CR Valdivia, ...
Biophysical Journal 122 (3), 164a, 2023
2023
Cryo-EM studies of ryanodine receptor disease mutant and modulation by calmodulin
YS Chen, KA Woll, O Haji-Ghassemi, F Van Petegem
Biophysical Journal 121 (3), 175a, 2022
2022
Poly (A) binding protein is required for mRNP remodeling to form P-bodies in mammalian cells
J Xie, Y Chen, X Wei, G Kozlov, K Gehring
bioRxiv, 2021.02. 07.430159, 2021
2021
Paip2 associates with PABPC1 on mRNA, and may facilitate PABPC1 dissociation from mRNA upon deadenylation
J Xie, X Wei, G Kozlov, Y Chen, M Menade, K Gehring
bioRxiv, 2021.02. 07.430161, 2021
2021
THE CYCLIC NUCLEOTIDEBINDING HOMOLOGY DOMAIN OF THE INTEGRAL MEMBRANE PROTEIN CNNM MEDIATES DIMERIZATION AND IS REQUIRED FOR MG2+ EFFLUX ACTIVITY
YS Chen, G Kozlov, R Fakih, Y Funato, H Miki, K Gehring
PROTEIN SCIENCE 28, 83-83, 2019
2019
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