Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases W Xu, H Yang, Y Liu, Y Yang, P Wang, SH Kim, S Ito, C Yang, P Wang, ... Cancer cell 19 (1), 17-30, 2011 | 3095 | 2011 |
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α S Zhao, Y Lin, W Xu, W Jiang, Z Zha, P Wang, W Yu, Z Li, L Gong, Y Peng, ... Science 324 (5924), 261-265, 2009 | 1410 | 2009 |
Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas P Wang, Q Dong, C Zhang, PF Kuan, Y Liu, WR Jeck, JB Andersen, ... Oncogene 32 (25), 3091-3100, 2013 | 444 | 2013 |
WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation Y Wang, M Xiao, X Chen, L Chen, Y Xu, L Lv, P Wang, H Yang, S Ma, ... Molecular cell 57 (4), 662-673, 2015 | 315 | 2015 |
Oncometabolite D-2-hydroxyglutarate inhibits ALKBH DNA repair enzymes and sensitizes IDH mutant cells to alkylating agents P Wang, J Wu, S Ma, L Zhang, J Yao, KA Hoadley, MD Wilkerson, ... Cell reports 13 (11), 2353-2361, 2015 | 218 | 2015 |
Cancer metabolism and tumor microenvironment: fostering each other? Y Yuan, H Li, W Pu, L Chen, D Guo, H Jiang, B He, S Qin, K Wang, N Li, ... Science China Life Sciences, 1-44, 2022 | 88 | 2022 |
Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis R Sun, Z Zhang, R Bao, X Guo, Y Gu, W Yang, J Wei, X Chen, L Tong, ... Journal of hepatology 77 (2), 453-466, 2022 | 70 | 2022 |
CRL3s: the BTB-CUL3-RING E3 ubiquitin ligases P Wang, J Song, D Ye Cullin-RING Ligases and Protein Neddylation: Biology and Therapeutics, 211-223, 2020 | 39 | 2020 |
The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response YR Zeng, JB Song, D Wang, ZX Huang, C Zhang, YP Sun, G Shu, Y Xiong, ... The Journal of Clinical Investigation 133 (6), 2023 | 28 | 2023 |
CRL4DCAF1/VprBP E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development XR Han, N Sasaki, SC Jackson, P Wang, Z Li, MD Smith, L Xie, X Chen, ... Science Advances 6 (51), eabd6078, 2020 | 24 | 2020 |
Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity X Chen, W Zhou, RH Song, S Liu, S Wang, Y Chen, C Gao, C He, J Xiao, ... Science advances 8 (4), eabl5220, 2022 | 21 | 2022 |
Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network YK Xia, YR Zeng, ML Zhang, P Liu, F Liu, H Zhang, CX He, YP Sun, ... Protein & cell 12 (7), 557-577, 2021 | 21 | 2021 |
Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development P Wang, F Yan, Z Li, Y Yu, SE Parnell, Y Xiong The Journal of Clinical Investigation 129 (10), 4393-4407, 2019 | 18 | 2019 |