| N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines … O Andries, S Mc Cafferty, SC De Smedt, R Weiss, NN Sanders, T Kitada Journal of Controlled Release 217, 337-344, 2015 | 578 | 2015 |
| Programming gene and engineered-cell therapies with synthetic biology T Kitada, B DiAndreth, B Teague, R Weiss Science 359 (6376), eaad1067, 2018 | 259 | 2018 |
| Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery L Wroblewska, T Kitada, K Endo, V Siciliano, B Stillo, H Saito, R Weiss Nature biotechnology 33 (8), 839-841, 2015 | 237 | 2015 |
| The SIRT2 deacetylase regulates autoacetylation of p300 JC Black, A Mosley, T Kitada, M Washburn, M Carey Molecular cell 32 (3), 449-455, 2008 | 197 | 2008 |
| Topoisomerase II binds nucleosome-free DNA and acts redundantly with topoisomerase I to enhance recruitment of RNA Pol II in budding yeast AS Sperling, KS Jeong, T Kitada, M Grunstein Proceedings of the National Academy of Sciences 108 (31), 12693-12698, 2011 | 87 | 2011 |
| Mechanism for epigenetic variegation of gene expression at yeast telomeric heterochromatin T Kitada, BG Kuryan, NNH Tran, C Song, Y Xue, M Carey, M Grunstein Genes & development 26 (21), 2443-2455, 2012 | 76 | 2012 |
| Small-molecule-based regulation of RNA-delivered circuits in mammalian cells TE Wagner, JR Becraft, K Bodner, B Teague, X Zhang, A Woo, E Porter, ... Nature chemical biology 14 (11), 1043-1050, 2018 | 71 | 2018 |
| The Rpd3 core complex is a chromatin stabilization module XF Chen, B Kuryan, T Kitada, N Tran, JY Li, S Kurdistani, M Grunstein, ... Current Biology 22 (1), 56-63, 2012 | 60 | 2012 |
| The Ino80 complex prevents invasion of euchromatin into silent chromatin Y Xue, C Van, SK Pradhan, T Su, J Gehrke, BG Kuryan, T Kitada, ... Genes & Development 29 (4), 350-355, 2015 | 53 | 2015 |
| Synthetic biology devices and circuits for RNA-based ‘smart vaccines’: a propositional review O Andries, T Kitada, K Bodner, NN Sanders, R Weiss Expert review of vaccines 14 (2), 313-331, 2015 | 52 | 2015 |
| Model-driven engineering of gene expression from RNA replicons J Beal, TE Wagner, T Kitada, O Azizgolshani, JM Parker, D Densmore, ... ACS synthetic biology 4 (1), 48-56, 2015 | 41 | 2015 |
| γH2A is a component of yeast heterochromatin required for telomere elongation T Kitada, T Schleker, AS Sperling, W Xie, SM Gasser, M Grunstein Cell Cycle 10 (2), 293-300, 2011 | 30 | 2011 |
| In vivo validation of a reversible small molecule-based switch for synthetic self-amplifying mRNA regulation S Mc Cafferty, J De Temmerman, T Kitada, JR Becraft, R Weiss, DJ Irvine, ... Molecular Therapy 29 (3), 1164-1173, 2021 | 24 | 2021 |
| Accelerating vaccine innovation for emerging infectious diseases via parallel discovery J Barberio, J Becraft, ZB Chaouch, D Bertsimas, T Kitada, ML Li, AW Lo, ... Entrepreneurship and Innovation Policy and the Economy 2 (1), 9-39, 2023 | 3 | 2023 |
| Rna-based logic circuits with rna binding proteins, aptamers and small molecules R Weiss, L Wroblewska, V Siciliano, T Kitada, MH Foley, K Bodner, ... US Patent 11,351,271, 2022 | 2 | 2022 |
| STX-001, a locally administered LNP-formulated self-replicating mRNA that encodes the therapeutic payload IL-12, induces deep systemic immune responses to solid tumors RT Sowell, JS Khurana, Z Su, W Zhao, GN Shenoy, M Dey, AC Lemaire, ... Cancer Research 83 (7_Supplement), 2731-2731, 2023 | 1 | 2023 |
| A phase I trial of intratumoral STX-001: A novel self-replicating mRNA expressing IL-12 alone or with pembrolizumab in advanced solid tumors. JJ Luke, LC Kennedy, N Sankar, AM Menzies, ACJ van Akkooi, ... Journal of Clinical Oncology 42 (16_suppl), TPS2696-TPS2696, 2024 | | 2024 |
| Expression constructs and uses thereof T Kitada, J Becraft, R Sowell, J Khurana, A Simon, J Barberio, Z Weiyu, ... US Patent App. 18/260,831, 2024 | | 2024 |
| Methods and compositions for heterologous repRNA immunizations R Vogels, MVDN Kolfschoten, DJ Irvine, R Weiss, EB Porter, MB Melo, ... US Patent 11,964,007, 2024 | | 2024 |
| Lipid nanoparticle comprising modified nucleotides J Becraft, R Sowell, J Khurana, T Kitada US Patent App. 18/006,555, 2023 | | 2023 |
