| Molecular basis of USP7 inhibition by selective small-molecule inhibitors AP Turnbull, S Ioannidis, WW Krajewski, A Pinto-Fernandez, C Heride, ... Nature 550 (7677), 481-486, 2017 | 405 | 2017 |
| Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis T Wauer, KN Swatek, JL Wagstaff, C Gladkova, JN Pruneda, MA Michel, ... The EMBO journal 34 (3), 307-325, 2015 | 337 | 2015 |
| Electrophilic natural products and their biological targets M Gersch, J Kreuzer, SA Sieber Natural product reports 29 (6), 659-682, 2012 | 300 | 2012 |
| Mechanism and regulation of the Lys6-selective deubiquitinase USP30 M Gersch, C Gladkova, AF Schubert, MA Michel, S Maslen, D Komander Nature structural & molecular biology 24 (11), 920-930, 2017 | 199 | 2017 |
| Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne TET Mevissen, Y Kulathu, MPC Mulder, PP Geurink, SL Maslen, M Gersch, ... Nature 538 (7625), 402-405, 2016 | 156 | 2016 |
| AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control M Gersch, K Famulla, M Dahmen, C Göbl, I Malik, K Richter, VS Korotkov, ... Nature communications 6 (1), 6320, 2015 | 132 | 2015 |
| Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid S Düwel, C Hundshammer, M Gersch, B Feuerecker, K Steiger, A Buck, ... Nature communications 8 (1), 15126, 2017 | 131 | 2017 |
| Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins A Shen, PJ Lupardus, MM Gersch, AW Puri, VE Albrow, KC Garcia, ... Nature structural & molecular biology 18 (3), 364-371, 2011 | 94 | 2011 |
| Insights into structural network responsible for oligomerization and activity of bacterial virulence regulator caseinolytic protease P (ClpP) protein M Gersch, A List, M Groll, SA Sieber Journal of Biological Chemistry 287 (12), 9484-9494, 2012 | 84 | 2012 |
| USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation EV Rusilowicz-Jones, J Jardine, A Kallinos, A Pinto-Fernandez, ... Life science alliance 3 (8), 2020 | 81 | 2020 |
| Selective inhibition of the immunoproteasome by ligand‐induced crosslinking of the active site C Dubiella, H Cui, M Gersch, AJ Brouwer, SA Sieber, A Krüger, ... Angewandte Chemie International Edition 53 (44), 11969-11973, 2014 | 81 | 2014 |
| Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad E Zeiler, A List, F Alte, M Gersch, R Wachtel, M Poreba, M Drag, M Groll, ... Proceedings of the National Academy of Sciences 110 (28), 11302-11307, 2013 | 77 | 2013 |
| The mechanism of caseinolytic protease (ClpP) inhibition M Gersch, F Gut, VS Korotkov, J Lehmann, T Böttcher, M Rusch, ... Angewandte Chemie International Edition 52 (10), 3009-3014, 2013 | 68 | 2013 |
| Disruption of oligomerization and dehydroalanine formation as mechanisms for ClpP protease inhibition M Gersch, R Kolb, F Alte, M Groll, SA Sieber Journal of the American Chemical Society 136 (4), 1360-1366, 2014 | 63 | 2014 |
| Distinct USP25 and USP28 oligomerization states regulate deubiquitinating activity M Gersch, JL Wagstaff, AV Toms, B Graves, SMV Freund, D Komander Molecular cell 74 (3), 436-451. e7, 2019 | 61 | 2019 |
| Selective activation of human caseinolytic protease P (ClpP) M Stahl, VS Korotkov, D Balogh, LM Kick, M Gersch, A Pahl, P Kielkowski, ... Angewandte Chemie International Edition 57 (44), 14602-14607, 2018 | 47 | 2018 |
| Barrel-shaped ClpP proteases display attenuated cleavage specificities M Gersch, M Stahl, M Poreba, M Dahmen, A Dziedzic, M Drag, SA Sieber ACS chemical biology 11 (2), 389-399, 2016 | 46 | 2016 |
| USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma EJ Ruiz, A Pinto-Fernandez, AP Turnbull, L Lan, TM Charlton, HC Scott, ... Elife 10, e71596, 2021 | 37 | 2021 |
| Deuteration of Hyperpolarized 13C‐Labeled Zymonic Acid Enables Sensitivity‐Enhanced Dynamic MRI of pH C Hundshammer, S Düwel, SS Köcher, M Gersch, B Feuerecker, ... ChemPhysChem 18 (18), 2422-2425, 2017 | 30 | 2017 |
| Insights into ClpXP proteolysis: heterooligomerization and partial deactivation enhance chaperone affinity and substrate turnover in Listeria monocytogenes D Balogh, M Dahmen, M Stahl, M Poreba, M Gersch, M Drag, SA Sieber Chemical Science 8 (2), 1592-1600, 2017 | 29 | 2017 |
