| Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription A Siddiqui-Jain, CL Grand, DJ Bearss, LH Hurley Proceedings of the National Academy of Sciences 99 (18), 11593-11598, 2002 | 2546 | 2002 |
| Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? S Balasubramanian, LH Hurley, S Neidle Nature reviews Drug discovery 10 (4), 261-275, 2011 | 1740 | 2011 |
| DNA and its associated processes as targets for cancer therapy LH Hurley Nature Reviews Cancer 2 (3), 188-200, 2002 | 1695 | 2002 |
| Inhibition of human telomerase by a G-quadruplex-interactive compound D Sun, B Thompson, BE Cathers, M Salazar, SM Kerwin, JO Trent, ... Journal of medicinal chemistry 40 (14), 2113-2116, 1997 | 1078 | 1997 |
| Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular G-quadruplex MY Kim, H Vankayalapati, K Shin-Ya, K Wierzba, LH Hurley Journal of the American Chemical Society 124 (10), 2098-2099, 2002 | 712 | 2002 |
| G-quadruplex DNA: a potential target for anti-cancer drug design H Han, LH Hurley Trends in pharmacological sciences 21 (4), 136-142, 2000 | 677 | 2000 |
| Cationic Porphyrins as Telomerase Inhibitors: the Interaction of Tetra-(N-methyl-4-pyridyl)porphine with Quadruplex DNA RT Wheelhouse, D Sun, H Han, FX Han, LH Hurley Journal of the American Chemical Society 120 (13), 3261-3262, 1998 | 568 | 1998 |
| Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions Y Qin, LH Hurley Biochimie 90 (8), 1149-1171, 2008 | 560 | 2008 |
| Making sense of G‐quadruplex and i‐motif functions in oncogene promoters TA Brooks, S Kendrick, L Hurley The FEBS journal 277 (17), 3459-3469, 2010 | 541 | 2010 |
| Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells E Izbicka, RT Wheelhouse, E Raymond, KK Davidson, RA Lawrence, ... Cancer research 59 (3), 639-644, 1999 | 529 | 1999 |
| The Cationic Porphyrin TMPyP4 Down-Regulates c-MYC and Human Telomerase Reverse Transcriptase Expression and Inhibits Tumor Growth in Vivo CL Grand, H Han, RM Munoz, S Weitman, DD Von Hoff, LH Hurley, ... Molecular cancer therapeutics 1 (8), 565-573, 2002 | 525 | 2002 |
| NMR-based model of a telomerase-inhibiting compound bound to G-quadruplex DNA OY Fedoroff, M Salazar, H Han, VV Chemeris, SM Kerwin, LH Hurley Biochemistry 37 (36), 12367-12374, 1998 | 505 | 1998 |
| Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G … D Sun, K Guo, JJ Rusche, LH Hurley Nucleic acids research 33 (18), 6070-6080, 2005 | 490 | 2005 |
| The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4 J Seenisamy, EM Rezler, TJ Powell, D Tye, V Gokhale, CS Joshi, ... Journal of the American Chemical Society 126 (28), 8702-8709, 2004 | 470 | 2004 |
| The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of … D Sun, LH Hurley Journal of medicinal chemistry 52 (9), 2863-2874, 2009 | 454 | 2009 |
| Deconvoluting the Structural and Drug-Recognition Complexity of the G-Quadruplex-Forming Region Upstream of the bcl-2 P1 Promoter TS Dexheimer, D Sun, LH Hurley Journal of the American Chemical Society 128 (16), 5404-5415, 2006 | 446 | 2006 |
| Interactions of TMPyP4 and TMPyP2 with quadruplex DNA. Structural basis for the differential effects on telomerase inhibition FX Han, RT Wheelhouse, LH Hurley Journal of the American Chemical Society 121 (15), 3561-3570, 1999 | 440 | 1999 |
| Selective interactions of cationic porphyrins with G-quadruplex structures H Han, DR Langley, A Rangan, LH Hurley Journal of the American Chemical Society 123 (37), 8902-8913, 2001 | 432 | 2001 |
| NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region J Dai, D Chen, RA Jones, LH Hurley, D Yang Nucleic acids research 34 (18), 5133-5144, 2006 | 403 | 2006 |
| Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structure EM Rezler, J Seenisamy, S Bashyam, MY Kim, E White, WD Wilson, ... Journal of the American Chemical Society 127 (26), 9439-9447, 2005 | 400 | 2005 |
Haiyong HanTranslational Genomics Research Institute在 tgen.org 的电子邮件经过验证
