AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation GJ Gowans, SA Hawley, FA Ross, DG Hardie Cell metabolism 18 (4), 556-566, 2013 | 618 | 2013 |
The Na+/glucose cotransporter inhibitor canagliflozin activates AMPK by inhibiting mitochondrial function and increasing cellular AMP levels SA Hawley, RJ Ford, BK Smith, GJ Gowans, SJ Mancini, RD Pitt, EA Day, ... Diabetes 65 (9), 2784-2794, 2016 | 336 | 2016 |
Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells SA Hawley, FA Ross, GJ Gowans, P Tibarewal, NR Leslie, DG Hardie Biochemical Journal 459 (2), 275-287, 2014 | 264 | 2014 |
AMPK: a cellular energy sensor primarily regulated by AMP GJ Gowans, DG Hardie Biochemical Society transactions 42 (1), 71-75, 2014 | 178 | 2014 |
Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α EA Rog-Zielinska, MA Craig, JR Manning, RV Richardson, GJ Gowans, ... Cell death and differentiation 22 (7), 1106, 2015 | 142 | 2015 |
AMPK causes cell cycle arrest in LKB1-deficient cells via activation of CAMKK2 S Fogarty, FA Ross, DV Ciruelos, A Gray, GJ Gowans, DG Hardie Molecular Cancer Research 14 (8), 683-695, 2016 | 83 | 2016 |
The INO80 complex requires the Arp5-Ies6 subcomplex for chromatin remodeling and metabolic regulation W Yao, DA King, SL Beckwith, GJ Gowans, K Yen, C Zhou, AJ Morrison Molecular and cellular biology 36 (6), 979-991, 2016 | 62 | 2016 |
Mechanisms of paradoxical activation of AMPK by the kinase inhibitors SU6656 and sorafenib FA Ross, SA Hawley, FR Auciello, GJ Gowans, A Atrih, DJ Lamont, ... Cell chemical biology 24 (7), 813-824. e4, 2017 | 58 | 2017 |
PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain TE Jensen, FA Ross, M Kleinert, L Sylow, JR Knudsen, GJ Gowans, ... Biochemical Journal 467 (3), 461-472, 2015 | 53 | 2015 |
INO80 chromatin remodeling coordinates metabolic homeostasis with cell division GJ Gowans, AN Schep, KM Wong, DA King, WJ Greenleaf, AJ Morrison Cell reports 22 (3), 611-623, 2018 | 38 | 2018 |
The INO80 chromatin remodeler sustains metabolic stability by promoting TOR signaling and regulating histone acetylation SL Beckwith, EK Schwartz, PE Garcia-Nieto, DA King, GJ Gowans, ... PLoS genetics 14 (2), e1007216, 2018 | 34 | 2018 |
Intact Cell Assays to Monitor AMPK and Determine the Contribution of the AMP-Binding or ADaM Sites to Activation SA Hawley, FA Fyffe, FM Russell, GJ Gowans, DG Hardie AMPK, 239-253, 2018 | 9 | 2018 |