GDF15 induces anorexia through nausea and emesis T Borner, ED Shaulson, MY Ghidewon, AB Barnett, CC Horn, RP Doyle, ... Cell metabolism 31 (2), 351-362. e5, 2020 | 169 | 2020 |
GIP receptor agonism attenuates GLP-1 receptor agonist–induced nausea and emesis in preclinical models T Borner, CE Geisler, SM Fortin, R Cosgrove, J Alsina-Fernandez, ... Diabetes 70 (11), 2545-2553, 2021 | 84 | 2021 |
GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats SM Fortin, RK Lipsky, R Lhamo, J Chen, E Kim, T Borner, HD Schmidt, ... Science translational medicine 12 (533), eaay8071, 2020 | 76 | 2020 |
GDF15 induces an aversive visceral malaise state that drives anorexia and weight loss T Borner, HS Wald, MY Ghidewon, B Zhang, Z Wu, BC De Jonghe, ... Cell Reports 31 (3), 2020 | 67 | 2020 |
Anorexia‐cachexia syndrome in hepatoma tumour‐bearing rats requires the area postrema but not vagal afferents and is paralleled by increased MIC‐1/GDF15 T Borner, M Arnold, J Ruud, SN Breit, W Langhans, TA Lutz, A Blomqvist, ... Journal of cachexia, sarcopenia and muscle 8 (3), 417-427, 2017 | 47 | 2017 |
The ghrelin receptor agonist HM01 mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats T Borner, L Loi, C Pietra, C Giuliano, TA Lutz, T Riediger American Journal of Physiology-Regulatory, Integrative and Comparative …, 2016 | 34 | 2016 |
A vitamin B12 conjugate of exendin‐4 improves glucose tolerance without associated nausea or hypophagia in rodents EG Mietlicki‐Baase, CG Liberini, JL Workinger, RL Bonaccorso, T Borner, ... Diabetes, Obesity and Metabolism 20 (5), 1223-1234, 2018 | 33 | 2018 |
The role of GIP in the regulation of GLP-1 satiety and nausea MR Hayes, T Borner, BC De Jonghe Diabetes 70 (9), 1956-1961, 2021 | 31 | 2021 |
Brainstem GLP-1 signalling contributes to cancer anorexia-cachexia syndrome in the rat T Borner, CG Liberini, TA Lutz, T Riediger Neuropharmacology 131, 282-290, 2018 | 30 | 2018 |
GIPR agonism inhibits PYY-induced nausea-like behavior RJ Samms, R Cosgrove, BM Snider, EC Furber, BA Droz, DA Briere, ... Diabetes 71 (7), 1410-1423, 2022 | 28 | 2022 |
Design and evaluation of peptide dual-agonists of GLP-1 and NPY2 receptors for glucoregulation and weight loss with mitigated nausea and emesis BT Milliken, C Elfers, OG Chepurny, KS Chichura, IR Sweet, T Borner, ... Journal of medicinal chemistry 64 (2), 1127-1138, 2021 | 24 | 2021 |
Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation RM Leon, T Borner, DJ Reiner, LM Stein, R Lhamo, BC De Jonghe, ... Neuropsychopharmacology 44 (10), 1742-1751, 2019 | 24 | 2019 |
Lipopolysaccharide inhibits ghrelin-excited neurons of the arcuate nucleus and reduces food intake via central nitric oxide signaling T Borner, S Pinkernell, TA Lutz, T Riediger Brain, behavior, and immunity 26 (6), 867-879, 2012 | 24 | 2012 |
The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats CG Liberini, T Borner, CN Boyle, TA Lutz Molecular metabolism 5 (10), 834-843, 2016 | 23 | 2016 |
Glucagon‐like peptide‐1 in diabetes care: Can glycaemic control be achieved without nausea and vomiting? T Borner, IC Tinsley, RP Doyle, MR Hayes, BC De Jonghe British journal of pharmacology 179 (4), 542-556, 2022 | 22 | 2022 |
Growth differentiation factor 15 (GDF15) and semaglutide inhibit food intake and body weight through largely distinct, additive mechanisms M Ghidewon, HS Wald, AD McKnight, BC De Jonghe, DM Breen, ... Diabetes, Obesity and Metabolism 24 (6), 1010-1020, 2022 | 21 | 2022 |
Corrination of a GLP-1 receptor agonist for glycemic control without emesis T Borner, JL Workinger, IC Tinsley, SM Fortin, LM Stein, OG Chepurny, ... Cell reports 31 (11), 2020 | 21 | 2020 |
A second‐generation glucagon‐like peptide‐1 receptor agonist mitigates vomiting and anorexia while retaining glucoregulatory potency in lean diabetic and emetic mammalian models T Borner, ED Shaulson, IC Tinsley, LM Stein, CC Horn, MR Hayes, ... Diabetes, Obesity and Metabolism 22 (10), 1729-1741, 2020 | 15 | 2020 |
Single nuclei RNA sequencing of the rat AP and NTS following GDF15 treatment BC Reiner, RC Crist, T Borner, RP Doyle, MR Hayes, BC De Jonghe Molecular metabolism 56, 101422, 2022 | 11 | 2022 |
Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats RM Leon, T Borner, LM Stein, NA Urrutia, BC De Jonghe, HD Schmidt, ... Neuropharmacology 187, 108477, 2021 | 10 | 2021 |