Parkin function in Parkinson's disease C Arkinson, H Walden Science 360 (6386), 267-268, 2018 | 81 | 2018 |
Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA ML Rennie, K Lemonidis, C Arkinson, VK Chaugule, M Clarke, J Streetley, ... EMBO reports 21 (7), e50133, 2020 | 37 | 2020 |
Structural basis of FANCD2 deubiquitination by USP1− UAF1 ML Rennie, C Arkinson, VK Chaugule, R Toth, H Walden Nature Structural & Molecular Biology 28 (4), 356-364, 2021 | 35 | 2021 |
Allosteric targeting of the Fanconi anemia ubiquitin-conjugating enzyme Ube2T by fragment screening FE Morreale, A Bortoluzzi, VK Chaugule, C Arkinson, H Walden, A Ciulli Journal of medicinal chemistry 60 (9), 4093-4098, 2017 | 35 | 2017 |
Mechanism, specificity, and function of FANCD2‐FANCI ubiquitination and deubiquitination K Lemonidis, C Arkinson, ML Rennie, H Walden The FEBS Journal 289 (16), 4811-4829, 2022 | 31 | 2022 |
Allosteric mechanism for site-specific ubiquitination of FANCD2 VK Chaugule, C Arkinson, ML Rennie, O Kämäräinen, R Toth, H Walden Nature chemical biology 16 (3), 291-301, 2020 | 25 | 2020 |
Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1 C Arkinson, VK Chaugule, R Toth, H Walden Life Science Alliance 1 (5), 2018 | 22 | 2018 |
The Ufd1 cofactor determines the linkage specificity of polyubiquitin chain engagement by the AAA+ ATPase Cdc48 C Williams, KC Dong, C Arkinson, A Martin Molecular cell 83 (5), 759-769. e7, 2023 | 17 | 2023 |
Enzymatic preparation of monoubiquitinated FANCD2 and FANCI proteins VK Chaugule, C Arkinson, R Toth, H Walden Methods in Enzymology 618, 73-104, 2019 | 14 | 2019 |
Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site ML Rennie, C Arkinson, VK Chaugule, H Walden Science Advances 8 (39), eabq6353, 2022 | 11 | 2022 |
Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination K Lemonidis, ML Rennie, C Arkinson, VK Chaugule, M Clarke, J Streetley, ... The EMBO Journal 42 (3), e111898, 2023 | 8 | 2023 |
Allosteric network in Ube2T drives specificity for RING E3 catalysed ubiquitin signals VK Chaugule, C Arkinson, R Toth, H Walden bioRxiv, 429076, 2018 | 3 | 2018 |
Profiling ubiquitin signalling with UBIMAX reveals DNA damage- and SCFβ-Trcp1-dependent ubiquitylation of the actin-organizing protein Dbn1 CS Colding-Christensen, ES Kakulidis, J Arroyo-Gomez, IA Hendriks, ... Nature Communications 14 (1), 8293, 2023 | 2 | 2023 |
Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279 ML Rennie, M Gundogdu, C Arkinson, S Liness, S Frame, H Walden Journal of Medicinal Chemistry, 2024 | | 2024 |
Cryo-EM structure of the CDK2-cyclin A-CDC25A complex RJ Rowland, S Korolchuk, M Salamina, NJ Tatum, JR Ault, S Hart, ... Nature Communications, 2024 | | 2024 |
Nub1 traps unfolded FAT10 for ubiquitin-independent degradation by the 26S proteasome C Arkinson, KC Dong, CL Gee, SM Costello, S Marqusee, A Martin bioRxiv, 2024.06. 12.598715, 2024 | | 2024 |
Preparation of site-specifically fluorophore-labeled polyubiquitin chains for FRET studies of Cdc48 substrate processing C Williams, KC Dong, C Arkinson, A Martin STAR protocols 4 (4), 102659, 2023 | | 2023 |
Structural and biochemical basis of FANCI-FANCD2 interdependent ubiquitination K Lemonidis, ML Rennie, C Arkinson, VK Chaugule, M Clarke, J Streetley, ... bioRxiv, 2022.04. 07.487446, 2022 | | 2022 |
Regulation and substrate specificity of the USP1-UAF1 deubiquitinase complex C Arkinson University of Glasgow, 2020 | | 2020 |
Validation Report Service P Leone, C Bebeacua, O Opota, C Kellenberger, B Klaholz, C Cambillau, ... | | |