| Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with … AA Adjei, RB Cohen, W Franklin, C Morris, D Wilson, JR Molina, ... Journal of clinical oncology 26 (13), 2139-2146, 2008 | 691 | 2008 |
| Regenerable fiber-optic-based immunosensor FV Bright, TA Betts, KS Litwiler Analytical Chemistry 62 (10), 1065-1069, 1990 | 174 | 1990 |
| Silanization of radio frequency glow discharge modified expanded poly (tetrafluoroethylene) using (aminopropyl) triethoxysilane DJ Hook, TG Vargo, JA Gardella Jr, KS Litwiler, FV Bright Langmuir 7 (1), 142-151, 1991 | 104 | 1991 |
| Advances in multifrequency phase and modulation fluorescence analysis FV Bright, TA Betts, KS Litwiler Critical Reviews in Analytical Chemistry 21 (6), 389-405, 1990 | 84 | 1990 |
| A phase 1 dose‐escalation study of ARRY‐520, a kinesin spindle protein inhibitor, in patients with advanced myeloid leukemias HJ Khoury, G Garcia‐Manero, G Borthakur, T Kadia, MC Foudray, ... Cancer 118 (14), 3556-3564, 2012 | 78 | 2012 |
| A phase 1 and 2 study of Filanesib alone and in combination with low‐dose dexamethasone in relapsed/refractory multiple myeloma JJ Shah, JL Kaufman, JA Zonder, AD Cohen, WI Bensinger, BW Hilder, ... Cancer 123 (23), 4617-4630, 2017 | 69 | 2017 |
| A phase I study of MEK inhibitor MEK162 (ARRY-438162) in patients with biliary tract cancer. RS Finn, MM Javle, BR Tan, CD Weekes, JC Bendell, A Patnaik, GN Khan, ... Journal of Clinical Oncology 30 (4_suppl), 220-220, 2012 | 55 | 2012 |
| First-in-human phase 1 study of filanesib (ARRY-520), a kinesin spindle protein inhibitor, in patients with advanced solid tumors PM LoRusso, PH Goncalves, L Casetta, JA Carter, K Litwiler, D Roseberry, ... Investigational new drugs 33, 440-449, 2015 | 50 | 2015 |
| Enhanced performance of fibre-optic immunoprobes using refunctionalized fluoropolymers as the substratum FV Bright, KS Litwiler, TG Vargo, JA Gardella Jr Analytica chimica acta 262 (2), 323-330, 1992 | 45 | 1992 |
| Fiber-optic-based immunosensors for haptens TA Betts, GC Catena, J Huang, KS Litwiler, J Zhang, JA Zagrobelny, ... Analytica chimica acta 246 (1), 55-63, 1991 | 43 | 1991 |
| Abstract B243: A phase I dose-escalation study of MEK inhibitor MEK162 (ARRY-438162) in patients with advanced solid tumors. JC Bendell, K Papadopoulos, SF Jones, E Barrett, K Guthrie, CL Kass, ... Molecular Cancer Therapeutics 10 (11_Supplement), B243-B243, 2011 | 41 | 2011 |
| Determination of the transduction mechanism for optical sensors based on rhodamine 6G-impregnated perfluorosulfonate films using steady-state and frequency-domain fluorescence KS Litwiler, PM Kluczynski, FV Bright Analytical chemistry 63 (8), 797-802, 1991 | 35 | 1991 |
| ARRY-520 shows durable responses in patients with relapsed/refractory multiple myeloma in a phase 1 dose-escalation study JJ Shah, J Zonder, A Cohen, RZ Orlowski, R Alexanian, SK Thomas, ... blood 118 (21), 1860, 2011 | 29 | 2011 |
| Simple fiber-optic sensor based on immobilized β-cyclodextrin KS Litwiler, GC Catena, FV Bright Analytica chimica acta 237, 485-490, 1990 | 29 | 1990 |
| A Phase Ib/II Study of WNT974 + Encorafenib + Cetuximab in Patients With BRAF V600E-Mutant KRAS Wild-Type Metastatic Colorectal Cancer J Tabernero, E Van Cutsem, E Garralda, D Tai, F De Braud, R Geva, ... The oncologist 28 (3), 230-238, 2023 | 28 | 2023 |
| Utilizing physiologically based pharmacokinetic modeling to inform formulation and clinical development for a compound with pH-dependent solubility J Chung, F Alvarez-Nunez, V Chow, D Daurio, J Davis, M Dodds, ... Journal of Pharmaceutical Sciences 104 (4), 1522-1532, 2015 | 25 | 2015 |
| ARRY-142886, a potent and selective MEK inhibitor: III) Efficacy in murine xenograft models correlates with decreased ERK phosphorylation P Lee, E Wallace, T Yeh, G Poch, K Litwiler, T Pheneger, J Lyssikatos, ... Proc Am Assoc Cancer Res 45, 3890, 2004 | 25 | 2004 |
| Multicomponent fluorometric analysis using a fiber-optic probe FV Bright, KS Litwiler Analytical chemistry 61 (14), 1510-1513, 1989 | 22 | 1989 |
| Effects of inaccurate reference lifetimes on interpreting frequency-domain fluorescence data KS Litwiler, J Huang, FV Bright Analytical chemistry 62 (5), 471-476, 1990 | 20 | 1990 |
| A first in human dose-ranging study to assess the pharmacokinetics, pharmacodynamics, and toxicities of the MEK inhibitor, ARRY-142886 (AZD6244) in patients with advanced solid … LQM Chow, SG Eckhardt, JM Reid, J Molina, L Hanson, J Piens, ... Intern. Conf. on Mol. Targets and Cancer Ther, EORTC, 2005 | 18 | 2005 |
