Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ... Nature 556 (7699), 113-117, 2018 | 1344 | 2018 |
Macrophage immunometabolism: where are we (going)? J Van den Bossche, LA O’Neill, D Menon Trends in immunology 38 (6), 395-406, 2017 | 896 | 2017 |
Glutathione transferases, regulators of cellular metabolism and physiology PG Board, D Menon Biochimica et biophysica acta (bba)-general subjects 1830 (5), 3267-3288, 2013 | 491 | 2013 |
Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2 JO Early, D Menon, CA Wyse, MP Cervantes-Silva, Z Zaslona, RG Carroll, ... Proceedings of the National Academy of Sciences 115 (36), E8460-E8468, 2018 | 284 | 2018 |
Pyruvate kinase M2 is required for the expression of the immune checkpoint PD-L1 in immune cells and tumors EM Palsson-McDermott, L Dyck, Z Zasłona, D Menon, AF McGettrick, ... Frontiers in immunology 8, 1300, 2017 | 153 | 2017 |
A role for glutathione transferase Omega 1 (GSTO1-1) in the glutathionylation cycle D Menon, PG Board Journal of Biological Chemistry 288 (36), 25769-25779, 2013 | 140 | 2013 |
The induction of pro–IL-1β by lipopolysaccharide requires endogenous prostaglandin E2 production Z Zasłona, EM Pålsson-McDermott, D Menon, M Haneklaus, E Flis, ... The Journal of Immunology 198 (9), 3558-3564, 2017 | 99 | 2017 |
Structure, function and disease relevance of Omega-class glutathione transferases PG Board, D Menon Archives of toxicology 90, 1049-1067, 2016 | 71 | 2016 |
Glutathione transferase omega 1 is required for the lipopolysaccharide-stimulated induction of NADPH oxidase 1 and the production of reactive oxygen species in macrophages D Menon, R Coll, PG Board Free Radical Biology and Medicine 73, 318-327, 2014 | 66 | 2014 |
GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway D Menon, R Coll, LAJ O'Neill, PG Board Journal of cell science 128 (10), 1982-1990, 2015 | 65 | 2015 |
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity D Menon, A Innes, AJ Oakley, JE Dahlstrom, LM Jensen, A Brüstle, ... Scientific reports 7 (1), 17832, 2017 | 55 | 2017 |
A fluorometric method to quantify protein glutathionylation using glutathione derivatization with 2, 3-naphthalenedicarboxaldehyde D Menon, PG Board Analytical biochemistry 433 (2), 132-136, 2013 | 40 | 2013 |
Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling MM Hughes, P Lavrencic, RC Coll, T Ve, DG Ryan, NC Williams, ... Proceedings of the National Academy of Sciences 114 (32), E6480-E6489, 2017 | 39 | 2017 |
Photoreceptor survival is regulated by GSTO1-1 in the degenerating retina N Fernando, Y Wooff, R Aggio-Bruce, JA Chu-Tan, H Jiao, C Dietrich, ... Investigative ophthalmology & visual science 59 (11), 4362-4374, 2018 | 11 | 2018 |
PNAS PLUS MM Hughes, P Lavrencic, RC Coll, T Ve, DG Ryan, NC Williams, ... PNAS 114 (32), 8447-8451, 2017 | | 2017 |
Jan Van den Bossche,* Luke A. O’Neill, 2 and D Menon | | 2017 |
GSTO1-1 plays a pro-inflammatory role in models of inflammation D Menon, A Innes, AJ Oakley, JE Dahlstrom, LM Jensen, P Tummala, ... | | 2017 |
Macrophages have a key role in innate immunity. They respond rapidly to pathogens and subsequently promote an anti-inflammatory phenotype to limit damage and promote tissue … EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ... | | |