Species-Specific Differences in the in Vitro Metabolism of Lasiocarpine MM Fashe, RO Juvonen, A Petsalo, J Rasanen, M Pasanen Chemical research in toxicology 28 (10), 2034-2044, 2015 | 35 | 2015 |
In Silico Prediction of the Site of Oxidation by Cytochrome P450 3A4 That Leads to the Formation of the Toxic Metabolites of Pyrrolizidine Alkaloids MM Fashe, RO Juvonen, A Petsalo, J Vepsäläinen, M Pasanen, ... Chemical Research in Toxicology 28 (4), 702-710, 2015 | 31 | 2015 |
Identification of a New Reactive Metabolite of Pyrrolizidine Alkaloid Retrorsine: (3H-Pyrrolizin-7-yl)methanol MM Fashe, RO Juvonen, A Petsalo, M Rahnasto-Rilla, S Auriola, ... Chemical Research in Toxicology 27 (11), 1950-1957, 2014 | 25 | 2014 |
Nuclear receptor CAR-ERα signaling regulates the estrogen sulfotransferase gene in the liver MJ Yi, M Fashe, S Arakawa, R Moore, T Sueyoshi, M Negishi Scientific Reports 10 (1), 5001, 2020 | 17 | 2020 |
Rational design of novel CYP2A6 inhibitors N Tani, RO Juvonen, H Raunio, M Fashe, J Leppänen, B Zhao, ... Bioorganic & medicinal chemistry 22 (23), 6655-6664, 2014 | 17 | 2014 |
Phenobarbital‐induced phosphorylation converts nuclear receptor RORα from a repressor to an activator of the estrogen sulfotransferase gene Sult1e1 in mouse … M Fashe, T Hashiguchi, MJ Yi, R Moore, M Negishi FEBS letters 592 (16), 2760-2768, 2018 | 14 | 2018 |
The impact of pregnancy on antihypertensive drug metabolism and pharmacokinetics: Current status and future directions IR Mulrenin, JE Garcia, MM Fashe, MS Loop, MA Daubert, RP Urrutia, ... Expert opinion on drug metabolism & toxicology 17 (11), 1261-1279, 2021 | 13 | 2021 |
Gendered vulnerability, perception and adaptation options of smallholder farmers to climate change in eastern Ethiopia MM Maja, AA Idiris, AT Terefe, MM Fashe Earth Systems and Environment 7 (1), 189-209, 2023 | 11 | 2023 |
Impact of pregnancy related hormones on drug metabolizing enzyme and transport protein concentrations in human hepatocytes MM Fashe, JK Fallon, TA Miner, JB Tiley, PC Smith, CR Lee Frontiers in Pharmacology 13, 1004010, 2022 | 10 | 2022 |
Sex-specific expression mechanism of hepatic estrogen inactivating enzyme and transporters in diabetic women M Fashe, MJ Yi, T Sueyoshi, M Negishi Biochemical pharmacology 190, 114662, 2021 | 9 | 2021 |
A phosphorylation-deficient mutant of retinoid X receptor α at Thr 167 alters fasting response and energy metabolism in mice T Sueyoshi, T Sakuma, S Shindo, M Fashe, T Kanayama, M Ray, R Moore, ... Laboratory Investigation 99 (10), 1470-1483, 2019 | 8 | 2019 |
Pregnancy related hormones increase CYP3A mediated buprenorphine metabolism in human hepatocytes: A comparison to CYP3A substrates nifedipine and midazolam MM Fashe, TA Miner, JK Fallon, AP Schauer, C Sykes, PC Smith, CR Lee Frontiers in pharmacology 14, 1218703, 2023 | 4 | 2023 |
Ser100-phosphorylated RORα orchestrates CAR and HNF4α to form active chromatin complex in response to phenobarbital to regulate induction of CYP2B6 M Fashe, T Hashiguchi, M Negishi, T Sueyoshi Molecular Pharmacology 97 (3), 191-201, 2020 | 4 | 2020 |
New glutathione conjugate of pyrrolizidine alkaloids produced by human cytosolic enzyme‐dependent reactions in vitro F Muluneh, MR Häkkinen, R El‐Dairi, M Pasanen, RO Juvonen Rapid Communications in Mass Spectrometry 32 (16), 1344-1352, 2018 | 4 | 2018 |
In vitro sulfonation of 7-hydroxycoumarin derivatives in liver cytosol of human and six animal species RO Juvonen, O Pentikäinen, J Huuskonen, J Timonen, O Kärkkäinen, ... Xenobiotica 50 (8), 885-893, 2020 | 3 | 2020 |
Impact of Sex and Pregnancy on Hepatic CYP3A4 Expression and Activity in a Humanized Mouse Model MM Fashe, TA Miner, VL Collazo, JT Grieco, JK Fallon, KD Jackson, ... Drug Metabolism and Disposition, 100025, 2024 | | 2024 |
Impact of Pregnancy on the Pharmacokinetics and Metabolism of Nicotinamide in Humans MM Fashe, TV Le, MN Gower, IR Mulrenin, KF Dorman, S Smith, ... Clinical Pharmacology & Therapeutics 115 (3), 556-564, 2024 | | 2024 |
Nuclear Receptors CAR, ERα and RORα Communicate via Phosphorylation to Differentially Regulate the SULT1E1 Gene Expression in Diabetic and Nondiabetic Human Livers MM Fashe, M Negishi The FASEB Journal 34 (S1), 1-1, 2020 | | 2020 |
Rational design of novel CYP2A6 inhibitors H Raunio, N Tani, R Juvonen, M Fashe, J Leppänen, B Zhao, S Miksys, ... Toxicology Letters, S181-S182, 2013 | | 2013 |
Phenobarbital-induced phosphorylation converts nuclear receptor RORa from a repressor to an activator of the estrogen sulfotransferase gene Sult1e1 in mouse livers M Fashe, T Hashiguchi, MJ Yi, R Moore, M Negishi | | |