| In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 LT Vassilev, BT Vu, B Graves, D Carvajal, F Podlaski, Z Filipovic, N Kong, ... Science 303 (5659), 844-848, 2004 | 5515 | 2004 |
| Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy C Tovar, J Rosinski, Z Filipovic, B Higgins, K Kolinsky, H Hilton, X Zhao, ... Proceedings of the National Academy of Sciences 103 (6), 1888-1893, 2006 | 819 | 2006 |
| Discovery of RG7112: a small-molecule MDM2 inhibitor in clinical development B Vu, P Wovkulich, G Pizzolato, A Lovey, Q Ding, N Jiang, JJ Liu, C Zhao, ... ACS medicinal chemistry letters 4 (5), 466-469, 2013 | 424 | 2013 |
| MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models C Tovar, B Graves, K Packman, Z Filipovic, BHM Xia, C Tardell, R Garrido, ... Cancer research 73 (8), 2587-2597, 2013 | 319 | 2013 |
| Phosphorylation of p53 on Key Serines Is Dispensable for Transcriptional Activation and Apoptosis*♦ T Thompson, C Tovar, H Yang, D Carvajal, BT Vu, Q Xu, GM Wahl, ... Journal of Biological Chemistry 279 (51), 53015-53022, 2004 | 286 | 2004 |
| Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors D Carvajal, C Tovar, H Yang, BT Vu, DC Heimbrook, LT Vassilev Cancer research 65 (5), 1918-1924, 2005 | 255 | 2005 |
| Discovery of [4-amino-2-(1-methanesulfonylpiperidin-4-ylamino) pyrimidin-5-yl](2, 3-difluoro-6-methoxyphenyl) methanone (R547), a potent and selective cyclin-dependent kinase … XJ Chu, W DePinto, D Bartkovitz, SS So, BT Vu, K Packman, C Lukacs, ... Journal of medicinal chemistry 49 (22), 6549-6560, 2006 | 136 | 2006 |
| Applications of Vinylogous Mannich Reactions. Total Syntheses of the Ergot Alkaloids Rugulovasines A and B and Setoclavine S Liras, CL Lynch, AM Fryer, BT Vu, SF Martin Journal of the American Chemical Society 123 (25), 5918-5924, 2001 | 122 | 2001 |
| Metal impurities cause false positives in high-throughput screening campaigns JC Hermann, Y Chen, C Wartchow, J Menke, L Gao, SK Gleason, ... ACS medicinal chemistry letters 4 (2), 197-200, 2013 | 117 | 2013 |
| Small-molecule inhibitors of the p53-MDM2 interaction BT Vu, L Vassilev Small-Molecule Inhibitors of Protein-Protein Interactions, 151-172, 2010 | 98 | 2010 |
| NMR structure of a complex between MDM2 and a small molecule inhibitor DC Fry, SD Emerson, S Palme, BT Vu, CM Liu, F Podlaski Journal of Biomolecular NMR 30, 163-173, 2004 | 86 | 2004 |
| Cis-imidazolines N Kong, EA Liu, BT Vu US Patent 6,734,302, 2004 | 70 | 2004 |
| Deconstruction of a nutlin: dissecting the binding determinants of a potent protein–protein interaction inhibitor DC Fry, C Wartchow, B Graves, C Janson, C Lukacs, U Kammlott, ... ACS medicinal chemistry letters 4 (7), 660-665, 2013 | 67 | 2013 |
| 4, 4, 5, 5, tetrasubstituted imidazolines Q Ding, BJ Graves, N Kong, JJ Liu, AJ Lovey, G Pizzolato, JL Roberts, ... US Patent 7,851,626, 2010 | 62 | 2010 |
| Glycosylation of fluoroquinolones through direct and oxygenated polymethylene linkages as a sugar-mediated active transport system for antimicrobials ME Jung, EC Yang, BT Vu, M Kiankarimi, E Spyrou, J Kaunitz Journal of medicinal chemistry 42 (19), 3899-3909, 1999 | 62 | 1999 |
| CIS-imidazolines GJ Haley, N Kong, EA Liu, BT Vu US Patent 7,893,278, 2011 | 60 | 2011 |
| Cis-imidazolines N Kong, EA Liu, BT Vu US Patent 6,617,346, 2003 | 51 | 2003 |
| Complete Diastereocontrol in Intramolecular 1, 3-Dipolar Cycloadditions of 2-Substituted 5-Hexenyl and 5-Heptenyl Nitrones: Application to the Synthesis of the β-Lactam … ME Jung, BT Vu The Journal of Organic Chemistry 61 (13), 4427-4433, 1996 | 39 | 1996 |
| Design of libraries targeting protein-protein interfaces. D Fry, KS Huang, P Di Lello, P Mohr, K Müller, SS So, T Harada, M Stahl, ... ChemMedChem 8 (5), 726-732, 2013 | 38 | 2013 |
| Chiral cis-imidazolines N Fotouhi, GJ Haley, KB Simonsen, BT Vu, SE Webber US Patent 7,964,724, 2011 | 38 | 2011 |
