SAMHD1 acts at stalled replication forks to prevent interferon induction F Coquel, MJ Silva, H Técher, K Zadorozhny, S Sharma, J Nieminuszczy, ... Nature 557 (7703), 57-61, 2018 | 408 | 2018 |
A mechanism for preventing asymmetric histone segregation onto replicating DNA strands C Yu, H Gan, A Serra-Cardona, L Zhang, S Gan, S Sharma, E Johansson, ... Science 361 (6409), 1386-1389, 2018 | 220 | 2018 |
Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity TM Mertz, S Sharma, A Chabes, PV Shcherbakova Proceedings of the National Academy of Sciences 112 (19), E2467-E2476, 2015 | 80 | 2015 |
Sphingolipid biosynthetic pathway genes FEN1 and SUR4 modulate amphotericin B resistance S Sharma, M Alfatah, VK Bari, Y Rawal, S Paul, K Ganesan Antimicrobial agents and chemotherapy, AAC. 02130-13, 2014 | 78 | 2014 |
Mrc1 and Rad9 cooperate to regulate initiation and elongation of DNA replication in response to DNA damage J Bacal, M Moriel‐Carretero, B Pardo, A Barthe, S Sharma, A Chabes, ... The EMBO journal 37 (21), e99319, 2018 | 71 | 2018 |
Polyphosphate is involved in cell cycle progression and genomic stability in Saccharomyces cerevisiae S Bru, JM Martínez‐Laínez, S Hernández‐Ortega, E Quandt, ... Molecular microbiology 101 (3), 367-380, 2016 | 69 | 2016 |
Telomere length homeostasis responds to changes in intracellular dNTP pools A Gupta, S Sharma, P Reichenbach, L Marjavaara, AK Nilsson, J Lingner, ... Genetics 193 (4), 1095-1105, 2013 | 68 | 2013 |
A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme X Xing, DP Kane, CR Bulock, EA Moore, S Sharma, A Chabes, ... Nature communications 10 (1), 374, 2019 | 66 | 2019 |
Checkpoint Kinase Rad53 Couples Leading-and Lagging-Strand DNA Synthesis under Replication Stress H Gan, C Yu, S Devbhandari, S Sharma, J Han, A Chabes, D Remus, ... Molecular Cell 68 (2), 446-455. e3, 2017 | 63 | 2017 |
Mec1 is activated at the onset of normal S phase by low-dNTP pools impeding DNA replication R Forey, A Poveda, S Sharma, A Barthe, I Padioleau, C Renard, ... Molecular cell 78 (3), 396-410. e4, 2020 | 57 | 2020 |
Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant A Sánchez, S Sharma, S Rozenzhak, A Roguev, NJ Krogan, A Chabes, ... Molecular and cellular biology 32 (21), 4445-4454, 2012 | 48 | 2012 |
Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling MC Lanz, S Oberly, EJ Sanford, S Sharma, A Chabes, MB Smolka Genes & development 32 (11-12), 822-835, 2018 | 44 | 2018 |
Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis TT Schmidt, G Reyes, K Gries, CÜ Ceylan, S Sharma, M Meurer, M Knop, ... Proceedings of the National Academy of Sciences 114 (22), E4442-E4451, 2017 | 42 | 2017 |
Plasma Membrane Proteolipid 3 Protein Modulates Amphotericin B Resistance throughSphingolipid Biosynthetic Pathway VK Bari, S Sharma, M Alfatah, AK Mondal, K Ganesan Scientific reports 5 (1), 9685, 2015 | 40 | 2015 |
Total RNA isolation from recalcitrant yeast cells MA Mannan, S Sharma, K Ganesan Analytical biochemistry 389 (1), 77-79, 2009 | 37 | 2009 |
Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria TJ Nicholls, H Spåhr, S Jiang, SJ Siira, C Koolmeister, S Sharma, ... Molecular cell 76 (5), 784-796. e6, 2019 | 31 | 2019 |
Determination of deoxyribonucleoside triphosphate concentrations in yeast cells by strong anion-exchange high-performance liquid chromatography coupled with ultraviolet detection S Jia, L Marjavaara, R Buckland, S Sharma, A Chabes DNA Replication: Methods and Protocols, 113-121, 2015 | 31 | 2015 |
Rtt105 functions as a chaperone for replication protein A to preserve genome stability S Li, Z Xu, J Xu, L Zuo, C Yu, P Zheng, H Gan, X Wang, L Li, S Sharma, ... The EMBO journal 37 (17), e99154, 2018 | 27 | 2018 |
A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance TT Schmidt, S Sharma, GX Reyes, K Gries, M Gross, B Zhao, JH Yuan, ... Nucleic acids research 47 (1), 237-252, 2019 | 26 | 2019 |
SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP T Davenne, J Klintman, S Sharma, RE Rigby, HTW Blest, C Cursi, ... Cell Reports 31 (6), 107640, 2020 | 24 | 2020 |