| Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM JG Viniegra, N Martínez, P Modirassari, JH Losa, CP Cobo, VJSA Lobo, ... Journal of Biological Chemistry 280 (6), 4029-4036, 2005 | 352 | 2005 |
| Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway and proinflammatory response in human pericytes I Guijarro-Muñoz, M Compte, A Álvarez-Cienfuegos, L Álvarez-Vallina, ... Journal of Biological Chemistry 289 (4), 2457-2468, 2014 | 318 | 2014 |
| Multivalent antibodies: when design surpasses evolution ÁM Cuesta, N Sainz-Pastor, J Bonet, B Oliva, L Álvarez-Vallina Trends in biotechnology 28 (7), 355-362, 2010 | 301 | 2010 |
| Programming Controlled Adhesion of E. coli to Target Surfaces, Cells, and Tumors with Synthetic Adhesins C Piñero-Lambea, G Bodelón, R Fernández-Periáñez, AM Cuesta, ... ACS synthetic biology 4 (4), 463-473, 2015 | 169 | 2015 |
| Antigen‐specific targeting of CD28‐mediated T cell co‐stimulation using chimeric single‐chain antibody variable fragment‐CD28 receptors L Alvarez‐Vallina, RE Hawkins European journal of immunology 26 (10), 2304-2309, 1996 | 167 | 1996 |
| Immune regulation by pericytes: modulating innate and adaptive immunity R Navarro, M Compte, L Álvarez-Vallina, L Sanz Frontiers in immunology 7, 480, 2016 | 154 | 2016 |
| The coming of age of engineered multivalent antibodies N Nunez-Prado, M Compte, S Harwood, A Alvarez-Mendez, S Lykkemark, ... Drug discovery today 20 (5), 588-594, 2015 | 151 | 2015 |
| A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity M Compte, SL Harwood, IG Muñoz, R Navarro, M Zonca, G Perez-Chacon, ... Nature communications 9 (1), 4809, 2018 | 127 | 2018 |
| Antibodies and gene therapy: teaching old ‘magic bullets’ new tricks L Sanz, B Blanco, L Alvarez-Vallina TRENDS in Immunology 25 (2), 85-91, 2004 | 127 | 2004 |
| Cells as vehicles for cancer gene therapy: the missing link between targeted vectors and systemic delivery? K Harrington, L Alvarez-Vallina, M Crittenden, M Gough, H Chong, ... Human gene therapy 13 (11), 1263-1280, 2002 | 119 | 2002 |
| Tumor immunotherapy using gene-modified human mesenchymal stem cells loaded into synthetic extracellular matrix scaffolds M Compte, ÁM Cuesta, D Sánchez-Martín, V Alonso-Camino, JL Vicario, ... Stem cells 27 (3), 753-760, 2009 | 116 | 2009 |
| Long-term in vivo imaging of human angiogenesis: critical role of bone marrow-derived mesenchymal stem cells for the generation of durable blood vessels L Sanz, P Santos-Valle, V Alonso-Camino, C Salas, A Serrano, JL Vicario, ... Microvascular research 75 (3), 308-314, 2008 | 99 | 2008 |
| Inhibition of tumor growth in vivo by in situ secretion of bispecific anti-CEA× anti-CD3 diabodies from lentivirally transduced human lymphocytes M Compte, B Blanco, F Serrano, ÁM Cuesta, L Sanz, A Bernad, P Holliger, ... Cancer gene therapy 14 (4), 380-388, 2007 | 80 | 2007 |
| Antibody engineering: facing new challenges in cancer therapy1 L Sanz, ÁM Cuesta, M Compte, L ÁLVAREZ‐VALLINA Acta Pharmacologica Sinica 26 (6), 641-648, 2005 | 78 | 2005 |
| ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy SL Harwood, A Alvarez-Cienfuegos, N Nuñez-Prado, M Compte, ... Oncoimmunology 7 (1), e1377874, 2018 | 77 | 2018 |
| In Vivo Tumor Targeting and Imaging with Engineered Trivalent Antibody Fragments Containing Collagen-Derived Sequences AM Cuesta, D Sánchez-Martín, L Sanz, J Bonet, M Compte, L Kremer, ... PLoS One 4 (4), e5381, 2009 | 77 | 2009 |
| Bispecific immunomodulatory antibodies for cancer immunotherapy B Blanco, C Domínguez-Alonso, L Alvarez-Vallina Clinical Cancer Research 27 (20), 5457-5464, 2021 | 75 | 2021 |
| Induction of human T lymphocyte cytotoxicity and inhibition of tumor growth by tumor-specific diabody-based molecules secreted from gene-modified bystander cells B Blanco, P Holliger, RG Vile, L Alvarez-Vallina The Journal of Immunology 171 (2), 1070-1077, 2003 | 75 | 2003 |
| The correlation between immune subtypes and consensus molecular subtypes in colorectal cancer identifies novel tumour microenvironment profiles, with prognostic and therapeutic … B Soldevilla, C Carretero-Puche, G Gomez-Lopez, F Al-Shahrour, ... European Journal of Cancer 123, 118-129, 2019 | 69 | 2019 |
| Single-chain antibody-based gene therapy: inhibition of tumor growth by in situ production of phage-derived human antibody fragments blocking functionally active sites of cell … L Sanz, P Kristensen, B Blanco, S Facteau, SJ Russell, G Winter, ... Gene therapy 9 (15), 1049-1053, 2002 | 65 | 2002 |
