| Specific inhibition of CK2α from an anchor outside the active site P Brear, C De Fusco, KH Georgiou, NJ Francis-Newton, CJ Stubbs, ... Chemical Science 7 (11), 6839-6845, 2016 | 66 | 2016 |
| A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066 C De Fusco, P Brear, J Iegre, KH Georgiou, HF Sore, M Hyvönen, ... Bioorganic & medicinal chemistry 25 (13), 3471-3482, 2017 | 64 | 2017 |
| Gluconeogenic precursor availability regulates flux through the glyoxylate shunt in Pseudomonas aeruginosa A Crousilles, SK Dolan, P Brear, DY Chirgadze, M Welch Journal of Biological Chemistry 293 (37), 14260-14269, 2018 | 53 | 2018 |
| ALDH2 mediates 5-nitrofuran activity in multiple species L Zhou, H Ishizaki, M Spitzer, KL Taylor, ND Temperley, SL Johnson, ... Chemistry & biology 19 (7), 883-892, 2012 | 53 | 2012 |
| Novel non-ATP competitive small molecules targeting the CK2 α/β interface P Brear, A North, J Iegre, KH Georgiou, A Lubin, L Carro, W Green, ... Bioorganic & Medicinal Chemistry 26 (11), 3016-3020, 2018 | 38 | 2018 |
| Second-generation CK2α inhibitors targeting the αD pocket J Iegre, P Brear, C De Fusco, M Yoshida, SL Mitchell, M Rossmann, ... Chemical Science 9 (11), 3041-3049, 2018 | 37 | 2018 |
| Chain alignment of collagen I deciphered using computationally designed heterotrimers AA Jalan, D Sammon, JD Hartgerink, P Brear, K Stott, SW Hamaia, ... Nature chemical biology 16 (4), 423-429, 2020 | 32 | 2020 |
| A random forest model for predicting allosteric and functional sites on proteins ASY Chen, NJ Westwood, P Brear, GW Rogers, L Mavridis, JBO Mitchell Molecular informatics 35 (3‐4), 125-135, 2016 | 32 | 2016 |
| Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction J Iegre, P Brear, DJ Baker, YS Tan, EL Atkinson, HF Sore, DH O'Donovan, ... Chemical Science 10 (19), 5056-5063, 2019 | 31 | 2019 |
| Chemical probes targeting the kinase CK2: A journey outside the catalytic box J Iegre, EL Atkinson, PD Brear, BM Cooper, M Hyvönen, DR Spring Organic & Biomolecular Chemistry 19 (20), 4380-4396, 2021 | 24 | 2021 |
| Functional metagenomic screening identifies an unexpected β-glucuronidase S Neun, P Brear, E Campbell, T Tryfona, K El Omari, A Wagner, P Dupree, ... Nature Chemical Biology 18 (10), 1096-1103, 2022 | 22 | 2022 |
| Downfalls of chemical probes acting at the kinase ATP-site: CK2 as a case study EL Atkinson, J Iegre, PD Brear, EA Zhabina, M Hyvönen, DR Spring Molecules 26 (7), 1977, 2021 | 22 | 2021 |
| Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors I Kufareva, B Bestgen, P Brear, R Prudent, B Laudet, V Moucadel, ... Scientific reports 9 (1), 15893, 2019 | 22 | 2019 |
| Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion SL Kidd, E Fowler, T Reinhardt, T Compton, N Mateu, H Newman, ... Chemical Science 11 (39), 10792-10801, 2020 | 16 | 2020 |
| Proposed allosteric inhibitors bind to the ATP site of CK2α P Brear, D Ball, K Stott, S D’Arcy, M Hyvönen Journal of medicinal chemistry 63 (21), 12786-12798, 2020 | 14 | 2020 |
| Evolutionary plasticity in the allosteric regulator-binding site of pyruvate kinase isoform PykA from Pseudomonas aeruginosa Y Abdelhamid, P Brear, J Greenhalgh, X Chee, T Rahman, M Welch Journal of Biological Chemistry 294 (42), 15505-15516, 2019 | 14 | 2019 |
| Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors M Reinecke, P Brear, L Vornholz, BT Berger, F Seefried, S Wilhelm, ... Nature Chemical Biology, 1-9, 2023 | 13 | 2023 |
| Synthesis and Structural Characterisation of Selective Non‐Carbohydrate‐Based Inhibitors of Bacterial Sialidases P Brear, J Telford, GL Taylor, NJ Westwood ChemBioChem 13 (16), 2374-2383, 2012 | 13 | 2012 |
| Targeting of Fumarate Hydratase from Mycobacterium tuberculosis Using Allosteric Inhibitors with a Dimeric-Binding Mode AJ Whitehouse, MDJ Libardo, M Kasbekar, PD Brear, G Fischer, ... Journal of medicinal chemistry 62 (23), 10586-10604, 2019 | 12 | 2019 |
| Aqueous methods for the preparation of 5′-substituted guanosine derivatives P Brear, GR Freeman, MC Shankey, M Trmčić, DRW Hodgson Chemical communications, 4980-4981, 2009 | 11 | 2009 |
