| Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1 T Umezu, H Tadokoro, K Azuma, S Yoshizawa, K Ohyashiki, JH Ohyashiki Blood, The Journal of the American Society of Hematology 124 (25), 3748-3757, 2014 | 614 | 2014 |
| Leukemia cell to endothelial cell communication via exosomal miRNAs T Umezu, K Ohyashiki, M Kuroda, JH Ohyashiki Oncogene 32 (22), 2747-2755, 2013 | 543 | 2013 |
| Exosomes derived from hypoxic leukemia cells enhance tube formation in endothelial cells H Tadokoro, T Umezu, K Ohyashiki, T Hirano, JH Ohyashiki Journal of Biological Chemistry 288 (48), 34343-34351, 2013 | 397 | 2013 |
| Clinical impact of down-regulated plasma miR-92a levels in non-Hodgkin's lymphoma K Ohyashiki, T Umezu, S Yoshizawa, Y Ito, M Ohyashiki, H Kawashima, ... PloS one 6 (2), e16408, 2011 | 113 | 2011 |
| Replenishing exosomes from older bone marrow stromal cells with miR-340 inhibits myeloma-related angiogenesis T Umezu, S Imanishi, K Azuma, C Kobayashi, S Yoshizawa, K Ohyashiki, ... Blood advances 1 (13), 812-823, 2017 | 92 | 2017 |
| Downregulated plasma miR-92a levels have clinical impact on multiple myeloma and related disorders S Yoshizawa, JH Ohyashiki, M Ohyashiki, T Umezu, K Suzuki, A Inagaki, ... Blood cancer journal 2 (1), e53-e53, 2012 | 91 | 2012 |
| Impact on cell to plasma ratio of miR-92a in patients with acute leukemia: in vivo assessment of cell to plasma ratio of miR-92a JH Ohyashiki, T Umezu, C Kobayashi, RS Hamamura, M Tanaka, ... BMC research notes 3, 1-8, 2010 | 85 | 2010 |
| Clinical relevance of plasma miR-106b levels in patients with chronic obstructive pulmonary disease S Soeda, JH Ohyashiki, K Ohtsuki, T Umezu, Y Setoguchi, K Ohyashiki International journal of molecular medicine 31 (3), 533-539, 2013 | 72 | 2013 |
| Exosomes promote bone marrow angiogenesis in hematologic neoplasia: the role of hypoxia JH Ohyashiki, T Umezu, K Ohyashiki Current opinion in hematology 23 (3), 268-273, 2016 | 70 | 2016 |
| Acerola exosome-like nanovesicles to systemically deliver nucleic acid medicine via oral administration T Umezu, M Takanashi, Y Murakami, S Ohno, K Kanekura, K Sudo, ... Molecular Therapy-Methods & Clinical Development 21, 199-208, 2021 | 63 | 2021 |
| Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm S Kubota, K Tokunaga, T Umezu, T Yokomizo-Nakano, Y Sun, M Oshima, ... Nature communications 10 (1), 1653, 2019 | 53 | 2019 |
| Reconstruction of oviduct and demonstration of epithelial fate determination in mice H Yamanouchi, T Umezu, Y Tomooka Biology of reproduction 82 (3), 528-533, 2010 | 48 | 2010 |
| Reduced fertility with impairment of early-stage embryos observed in mice lacking Lgr4 in epithelial tissues Y Mohri, T Umezu, S Hidema, H Tomisawa, A Akamatsu, S Kato, A Nawa, ... Fertility and sterility 94 (7), 2878-2881, 2010 | 41 | 2010 |
| Downregulation of plasma miR-215 in chronic myeloid leukemia patients with successful discontinuation of imatinib K Ohyashiki, T Umezu, S Katagiri, C Kobayashi, K Azuma, T Tauchi, ... International journal of molecular sciences 17 (4), 570, 2016 | 40 | 2016 |
| Follistatin-like-1, a diffusible mesenchymal factor determines the fate of epithelium T Umezu, H Yamanouchi, Y Iida, M Miura, Y Tomooka Proceedings of the National Academy of Sciences 107 (10), 4601-4606, 2010 | 38 | 2010 |
| Characterization of newly established clonal oviductal cell lines and differential hormonal reculation of gene expression T Umezu, M Hanazono, S Aizawa, Y Tomooka In Vitro Cellular & Developmental Biology-Animal 39, 146-156, 2003 | 37 | 2003 |
| Induction of multiple myeloma bone marrow stromal cell apoptosis by inhibiting extracellular vesicle miR-10a secretion T Umezu, S Imanishi, S Yoshizawa, C Kawana, JH Ohyashiki, ... Blood advances 3 (21), 3228-3240, 2019 | 34 | 2019 |
| Extracellular vesicle-mediated cell–cell communication in haematological neoplasms JH Ohyashiki, T Umezu, K Ohyashiki Philosophical Transactions of the Royal Society B: Biological Sciences 373 …, 2018 | 34 | 2018 |
| Up-regulated exosomal miRNA-140-3p in CML patients with musculoskeletal pain associated with discontinuation of tyrosine kinase inhibitors M Asano, T Umezu, S Katagiri, C Kobayashi, T Tauchi, M Gotoh, K Ando, ... International journal of hematology 105, 419-422, 2017 | 29 | 2017 |
| Constitutive activation of the ATM/BRCA1 pathway prevents DNA damage-induced apoptosis in 5-azacytidine-resistant cell lines S Imanishi, T Umezu, K Ohtsuki, C Kobayashi, K Ohyashiki, JH Ohyashiki Biochemical pharmacology 89 (3), 361-369, 2014 | 25 | 2014 |
