| Enzyme–substrate interface targeting by imidazole‐based γ‐secretase modulators activates γ‐secretase and stabilizes its interaction with APP D Petit, M Hitzenberger, M Koch, S Lismont, KM Zoltowska, T Enzlein, ... The EMBO Journal 41 (21), e111084, 2022 | 8 | 2022 |
| APP substrate ectodomain defines amyloid‐β peptide length by restraining γ‐secretase processivity and facilitating product release M Koch, T Enzlein, SY Chen, D Petit, S Lismont, M Zacharias, C Hopf, ... The EMBO Journal 42 (23), e114372, 2023 | 7 | 2023 |
| How Modulator Binding at the Amyloidβ-γ-Secretase Interface Enhances Substrate Binding and Attenuates Membrane Distortion SY Chen, M Koch, L Chávez-Gutiérrez, M Zacharias Journal of Medicinal Chemistry 66 (24), 16772-16782, 2023 | 1 | 2023 |
| APP substrate ectodomain defines A beta length by restraining gamma-secretase processivity and facilitating product release M Koch, T Enzlein, SY Chen, D Petit, S Lismont, M Zacharias, C Hopf, ... bioRxiv, 2023.09. 13.557360, 2023 | | 2023 |
| Signaling is silver, silence is golden: RHBDL2 intramembrane proteolysis prevents stochastic Ca2+ signaling in unstimulated cells M Koch, L Chávez-Gutiérrez Molecular Cell 81 (23), 4763-4765, 2021 | | 2021 |
