关注
Takanori Kanai
Takanori Kanai
未知所在单位机构
在 keio.jp 的电子邮件经过验证
标题
引用次数
引用次数
年份
Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids
M Matano, S Date, M Shimokawa, A Takano, M Fujii, Y Ohta, T Watanabe, ...
Nature medicine 21 (3), 256-262, 2015
11392015
The gut microbiota and inflammatory bowel disease
K Matsuoka, T Kanai
Seminars in immunopathology 37, 47-55, 2015
8902015
A colorectal tumor organoid library demonstrates progressive loss of niche factor requirements during tumorigenesis
M Fujii, M Shimokawa, S Date, A Takano, M Matano, K Nanki, Y Ohta, ...
Cell stem cell 18 (6), 827-838, 2016
7572016
Mapping the human genetic architecture of COVID-19
Writing group Writing group leaders Pathak Gita A. 6 Andrews Shea J. 7 Kanai ...
Nature 600 (7889), 472-477, 2021
7412021
Visualization and targeting of LGR5+ human colon cancer stem cells
M Shimokawa, Y Ohta, S Nishikori, M Matano, A Takano, M Fujii, S Date, ...
Nature 545 (7653), 187-192, 2017
6802017
Human pancreatic tumor organoids reveal loss of stem cell niche factor dependence during disease progression
T Seino, S Kawasaki, M Shimokawa, H Tamagawa, K Toshimitsu, M Fujii, ...
Cell stem cell 22 (3), 454-467. e6, 2018
5452018
Evidence-based clinical practice guidelines for inflammatory bowel disease
K Matsuoka, T Kobayashi, F Ueno, T Matsui, F Hirai, N Inoue, J Kato, ...
Journal of gastroenterology 53 (3), 305-353, 2018
5152018
Damaged epithelia regenerated by bone marrow–derived cells in the human gastrointestinal tract
R Okamoto, T Yajima, M Yamazaki, T Kanai, M Mukai, S Okamoto, ...
Nature medicine 8 (9), 1011-1017, 2002
5022002
CD4+ CD25bright T cells in human intestinal lamina propria as regulatory cells
S Makita, T Kanai, S Oshima, K Uraushihara, T Totsuka, T Sawada, ...
The Journal of Immunology 173 (5), 3119-3130, 2004
3502004
Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis
N Nakamoto, N Sasaki, R Aoki, K Miyamoto, W Suda, T Teratani, T Suzuki, ...
Nature microbiology 4 (3), 492-503, 2019
3352019
Free cholesterol accumulation in hepatic stellate cells: mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice
K Tomita, T Teratani, T Suzuki, M Shimizu, H Sato, K Narimatsu, Y Okada, ...
Hepatology 59 (1), 154-169, 2014
3282014
MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis
A Araki, T Kanai, T Ishikura, S Makita, K Uraushihara, R Iiyama, T Totsuka, ...
Journal of gastroenterology 40, 16-23, 2005
3182005
A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice
A Hayashi, T Sato, N Kamada, Y Mikami, K Matsuoka, T Hisamatsu, T Hibi, ...
Cell host & microbe 13 (6), 711-722, 2013
3042013
Imbalance of NKp44+ NKp46− and NKp44− NKp46+ natural killer cells in the intestinal mucosa of patients with Crohn's disease
T Takayama, N Kamada, H Chinen, S Okamoto, MT Kitazume, J Chang, ...
Gastroenterology 139 (3), 882-892. e3, 2010
2702010
Divergent routes toward Wnt and R-spondin niche independency during human gastric carcinogenesis
K Nanki, K Toshimitsu, A Takano, M Fujii, M Shimokawa, Y Ohta, ...
Cell 174 (4), 856-869. e17, 2018
2682018
Inhibition of dectin-1 signaling ameliorates colitis by inducing lactobacillus-mediated regulatory T cell expansion in the intestine
CE Tang, T Kamiya, Y Liu, M Kadoki, S Kakuta, K Oshima, M Hattori, ...
Cell host & microbe 18 (2), 183-197, 2015
2652015
Adalimumab monotherapy and a combination with azathioprine for Crohn’s disease: a prospective, randomized trial
T Matsumoto, S Motoya, K Watanabe, T Hisamatsu, H Nakase, ...
Journal of Crohn's and Colitis 10 (11), 1259-1266, 2016
2602016
Blockade of B7-H1 suppresses the development of chronic intestinal inflammation
T Kanai, T Totsuka, K Uraushihara, S Makita, T Nakamura, K Koganei, ...
The Journal of Immunology 171 (8), 4156-4163, 2003
2602003
A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells
T Teratani, K Tomita, T Suzuki, T Oshikawa, H Yokoyama, K Shimamura, ...
Gastroenterology 142 (1), 152-164. e10, 2012
2492012
Somatic inflammatory gene mutations in human ulcerative colitis epithelium
K Nanki, M Fujii, M Shimokawa, M Matano, S Nishikori, S Date, A Takano, ...
Nature 577 (7789), 254-259, 2020
2462020
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