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Romualdo Troisi
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Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer
R Troisi, V Napolitano, V Spiridonova, I Russo Krauss, F Sica
Nucleic acids research 46 (22), 12177-12185, 2018
622018
Duplex/quadruplex oligonucleotides: Role of the duplex domain in the stabilization of a new generation of highly effective anti-thrombin aptamers
IR Krauss, V Napolitano, L Petraccone, R Troisi, V Spiridonova, CA Mattia, ...
International journal of biological macromolecules 107, 1697-1705, 2018
412018
Exosite Binding in Thrombin: A Global Structural/Dynamic Overview of Complexes with Aptamers and Other Ligands
R Troisi, N Balasco, I Autiero, L Vitagliano, F Sica
International journal of molecular sciences 22 (19), 10803, 2021
322021
Antimicrobial Applications of Green Synthesized Bimetallic Nanoparticles from Ocimum basilicum
PR More, C Zannella, V Folliero, F Foglia, R Troisi, A Vergara, G Franci, ...
Pharmaceutics 14 (11), 2457, 2022
172022
Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12
I Smirnov, N Kolganova, R Troisi, F Sica, E Timofeev
Molecular Therapy-Nucleic Acids 23, 863-871, 2021
172021
Structure–Activity Relationship Study of a Potent α‐Thrombin Binding Aptamer Incorporating Hexitol Nucleotides
M De Fenza, E Eremeeva, R Troisi, H Yang, A Esposito, F Sica, ...
Chemistry–A European Journal 26 (43), 9589-9597, 2020
172020
Molecular dynamics simulations of human α-thrombin in different structural contexts: Evidence for an aptamer-guided cooperation between the two exosites
R Troisi, N Balasco, L Vitagliano, F Sica
Journal of Biomolecular Structure and Dynamics 39 (6), 2199-2209, 2021
142021
Structural and functional analysis of the simultaneous binding of two duplex/quadruplex aptamers to human α-thrombin
R Troisi, N Balasco, A Santamaria, L Vitagliano, F Sica
International Journal of Biological Macromolecules 181, 858-867, 2021
112021
Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide
R Troisi, V Napolitano, E Rossitto, W Osman, M Nagano, K Wakui, ...
Nucleic Acids Research 51 (16), 8880-8890, 2023
72023
A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers
R Troisi, C Riccardi, KP de Carvasal, M Smietana, F Morvan, ...
Molecular Therapy-Nucleic Acids 30, 585-594, 2022
72022
Aptamers: Functional-Structural Studies and Biomedical Applications
R Troisi, F Sica
International Journal of Molecular Sciences 23 (9), 4796, 2022
72022
New insight into the traditional model of the coagulation cascade and its regulation: illustrated review of a three-dimensional view
R Troisi, N Balasco, I Autiero, F Sica, L Vitagliano
Research and Practice in Thrombosis and Haemostasis, 102160, 2023
62023
Structural Insights into Protein–Aptamer Recognitions Emerged from Experimental and Computational Studies
R Troisi, N Balasco, I Autiero, L Vitagliano, F Sica
International Journal of Molecular Sciences 24 (22), 16318, 2023
52023
Protective Effects of Recombinant Human Angiogenin in Keratinocytes: New Insights on Oxidative Stress Response Mediated by RNases
R Culurciello, A Bosso, R Troisi, V Barrella, I Di Nardo, M Borriello, ...
International Journal of Molecular Sciences 23 (15), 8781, 2022
52022
The non-swapped monomeric structure of the arginine-binding protein from Thermotoga maritima
G Smaldone, A Ruggiero, N Balasco, A Abuhammad, I Autiero, D Caruso, ...
Acta Crystallographica Section F: Structural Biology Communications 75 (11 …, 2019
52019
Dirhodium tetraacetate binding to a B-DNA double helical dodecamer probed by X-ray crystallography and mass spectrometry
G Tito, R Troisi, G Ferraro, A Geri, L Massai, L Messori, F Sica, A Merlino
Dalton Transactions 52 (21), 6992-6996, 2023
42023
The structural features of an ancient ribonuclease from Salmo salar reveal an intriguing case of auto-inhibition
F Sica, IR Krauss, R Troisi, A Bosso, R Culurciello, C Carluccio, M Trapani, ...
International Journal of Biological Macromolecules 182, 659-668, 2021
32021
Tailoring the stress response of human skin cells by substantially limiting the nuclear localization of angiogenin
R Culurciello, I Di Nardo, A Bosso, F Tortora, R Troisi, F Sica, A Arciello, ...
Heliyon 10 (3), 2024
22024
Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study
R Troisi, F Galardo, G Ferraro, F Sica, A Merlino
Inorganic Chemistry 62 (2), 675-678, 2023
22023
Structural overview of DNA and RNA G-quadruplexes in their interaction with proteins
R Troisi, F Sica
Current Opinion in Structural Biology 87, 102846, 2024
2024
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