CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency N Matharu, S Rattanasopha, S Tamura, L Maliskova, Y Wang, A Bernard, ... Science 363 (6424), eaau0629, 2019 | 281 | 2019 |
Minor loops in major folds: enhancer–promoter looping, chromatin restructuring, and their association with transcriptional regulation and disease N Matharu, N Ahituv PLoS genetics 11 (12), e1005640, 2015 | 106 | 2015 |
Vertebrate Homologue of Drosophila GAGA Factor NK Matharu, T Hussain, R Sankaranarayanan, RK Mishra Journal of molecular biology 400 (3), 434-447, 2010 | 78 | 2010 |
Oestrogen engages brain MC4R signalling to drive physical activity in female mice WC Krause, R Rodriguez, B Gegenhuber, N Matharu, AN Rodriguez, ... Nature 599 (7883), 131-135, 2021 | 74 | 2021 |
Modulating gene regulation to treat genetic disorders N Matharu, N Ahituv Nature Reviews Drug Discovery 19 (11), 757-775, 2020 | 59 | 2020 |
Toward a neurospheroid niche model: Optimizing embedded 3D bioprinting for fabrication of neurospheroid brain-like co-culture constructs YCE Li, YA Jodat, R Samanipour, G Zorzi, K Zhu, M Hirano, K Chang, ... Biofabrication 13 (1), 015014, 2020 | 47 | 2020 |
Genetic variation in the SIM1 locus is associated with erectile dysfunction E Jorgenson, N Matharu, MR Palmer, J Yin, J Shan, TJ Hoffmann, KK Thai, ... Proceedings of the National Academy of Sciences 115 (43), 11018-11023, 2018 | 28 | 2018 |
A functionally conserved Polycomb response element from mouse HoxD complex responds to heterochromatin factors D Vasanthi, A Nagabhushan, NK Matharu, RK Mishra Scientific reports 3 (1), 3011, 2013 | 27 | 2013 |
Chromatin insulators and topological domains: adding new dimensions to 3D genome architecture NK Matharu, SH Ahanger Genes 6 (3), 790-811, 2015 | 20 | 2015 |
Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation F Inoue, WL Eckalbar, Y Wang, KK Murphy, N Matharu, C Vaisse, ... Nature metabolism 1 (4), 475-484, 2019 | 19 | 2019 |
CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder S Tamura, AD Nelson, PWE Spratt, H Kyoung, X Zhou, Z Li, J Zhao, ... BioRxiv, 2022.03. 30.486483, 2022 | 16 | 2022 |
Gene therapy for haploinsufficiency N Ahituv, N Matharu US Patent 11,730,828, 2023 | 7 | 2023 |
Transcriptomic mapping of neural diversity, differentiation and functional trajectory in ipsc-derived 3d brain organoid models K Kiaee, YA Jodat, NJ Bassous, N Matharu, SR Shin Cells 10 (12), 3422, 2021 | 7 | 2021 |
Asymmetron: a toolkit for the identification of strand asymmetry patterns in biological sequences I Georgakopoulos-Soares, I Mouratidis, GE Parada, N Matharu, ... Nucleic acids research 49 (1), e4-e4, 2021 | 6 | 2021 |
Role of vertebrate GAGA associated factor (vGAF) in early development of zebrafish NK Matharu, S Yadav, M Kumar, RK Mishra Cells & Development 166, 203682, 2021 | 5 | 2021 |
Estrogen Drives Melanocortin Neurons To Increase Spontaneous Activity and Reduce Sedentary Behavior WC Krause, R Rodriguez, B Gegenhuber, N Matharu, AN Rodriguez, ... bioRxiv, 794792, 2019 | 3 | 2019 |
Homeotic gene regulation: a paradigm for epigenetic mechanisms underlying organismal development NK Matharu, V Dasari, RK Mishra Epigenetics: Development and Disease, 177-207, 2012 | 3 | 2012 |
Promoter or enhancer activation by CRISPRa rescues haploinsufficiency caused obesity N Matharu, S Rattanasopha, L Maliskova, Y Wang, A Hardin, C Vaisse, ... BioRxiv, 140426, 2017 | 1 | 2017 |
Tone up your chromatin and stay young NK Matharu, RK Mishra Journal of biosciences 36, 5-11, 2011 | 1 | 2011 |
Massively parallel jumping assay decodes Alu retrotransposition activity N Matharu, J Zhao, A Sohota, L Deng, Y Hung, Z Li, J Sims, ... bioRxiv, 2024 | | 2024 |