Interleukin 6-mediated endothelial barrier disturbances can be attenuated by blockade of the IL6 receptor expressed in brain microvascular endothelial cells KG Blecharz-Lang, J Wagner, A Fries, M Nieminen-Kelhä, J Rösner, ... Translational stroke research 9, 631-642, 2018 | 105 | 2018 |
Intravascular inflammation triggers intracerebral activated microglia and contributes to secondary brain injury after experimental subarachnoid hemorrhage (eSAH) E Atangana, UC Schneider, K Blecharz, S Magrini, J Wagner, ... Translational stroke research 8, 144-156, 2017 | 104 | 2017 |
Mendelian randomization study of PCSK9 and HMG-CoA reductase inhibition and cognitive function DB Rosoff, AS Bell, J Jung, J Wagner, LA Mavromatis, FW Lohoff Journal of the American College of Cardiology 80 (7), 653-662, 2022 | 47 | 2022 |
Autocrine release of angiopoietin-2 mediates cerebrovascular disintegration in Moyamoya disease KG Blecharz, D Frey, T Schenkel, V Prinz, G Bedini, SM Krug, ... Journal of Cerebral Blood Flow & Metabolism 37 (4), 1527-1539, 2017 | 36 | 2017 |
Proprotein convertase subtilisin/kexin type 9 (PCSK9) in the central nervous system AS Bell, J Wagner, DB Rosoff, FW Lohoff Neuroscience & Biobehavioral Reviews, 105155, 2023 | 14 | 2023 |
Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging DB Rosoff, LA Mavromatis, AS Bell, J Wagner, J Jung, RE Marioni, ... Nature aging 3 (8), 1020-1035, 2023 | 12 | 2023 |
Additive effects of stress and alcohol exposure on accelerated epigenetic aging in alcohol use disorder J Jung, DL McCartney, J Wagner, J Yoo, AS Bell, LA Mavromatis, ... Biological psychiatry 93 (4), 331-341, 2023 | 11 | 2023 |
Comparing the relationships of genetically proxied PCSK9 inhibition with mood disorders, cognition, and dementia between men and women: a drug‐target mendelian randomization study AS Bell, DB Rosoff, LA Mavromatis, J Jung, J Wagner, FW Lohoff Journal of the American Heart Association 11 (21), e026122, 2022 | 11 | 2022 |
Alcohol use disorder is associated with DNA methylation-based shortening of telomere length and regulated by TESPA1: implications for aging J Jung, DL McCartney, J Wagner, DB Rosoff, M Schwandt, H Sun, ... Molecular Psychiatry 27 (9), 3875-3884, 2022 | 11 | 2022 |
Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier A Keller, M Nuvolone, I Abakumova, A Chincisan, R Reimann, M Avar, ... PLoS pathogens 14 (11), e1007424, 2018 | 11 | 2018 |
Multi-omic underpinnings of epigenetic aging and human longevity LA Mavromatis, DB Rosoff, AS Bell, J Jung, J Wagner, FW Lohoff Nature Communications 14 (1), 2236, 2023 | 7 | 2023 |
Intravascular inflammation triggers intracerebral activated microglia and contributes to secondary brain injury after experimental subarachnoid hemorrhage (eSAH). Transl Stroke … E Atangana, UC Schneider, K Blecharz, S Magrini, J Wagner, ... | 7 | |
Assessing the Impact of PCSK9 and HMGCR Inhibition on Liver Function: Drug-Target Mendelian Randomization Analyses in Four Ancestries DB Rosoff, AS Bell, J Wagner, LA Mavromatis, A Hamandi, L Park, J Jung, ... Cellular and Molecular Gastroenterology and Hepatology 17 (1), 29-40, 2024 | 4 | 2024 |
Multi‐omics analysis of alcohol effects on the liver in young and aged mice L Zillich, J Wagner, RH McMahan, LM Park, C Hodgkinson, EJ Kovacs, ... Addiction Biology 28 (12), e13342, 2023 | 3 | 2023 |
PCSK9 Base Editing Therapeutics and Ischemic Stroke J Wagner, AS Bell, FW Lohoff ACS Chemical Neuroscience 13 (23), 3210-3212, 2022 | 3 | 2022 |
Abstracts from the 20th international symposium on signal transduction at the blood-brain barriers A Małecki, J Skipor-Lahuta, M Toborek, NJ Abbott, DA Antonetti, EJ Su, ... Fluids and Barriers of the CNS 14, 1-23, 2017 | 2 | 2017 |
PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury J Wagner, LM Park, P Mukhopadhyay, C Matyas, E Trojnar, R Damadzic, ... Brain, Behavior, and Immunity 119, 494-506, 2024 | | 2024 |
Multi-Omics Analyses of Cortical Proteome and Single Cell-Type Transcriptome Identifies Novel Drug Targets for Problematic Drinking Behavior and Alcohol Use Disorder D Rosoff, J Wagner, A Bell, L Mavromatis, J Jung, F Lohoff Biological Psychiatry 95 (10), S21, 2024 | | 2024 |
Evaluating the Cardiovascular Impact of Genetically Proxied PCSK9 and HMGCR Inhibition in East Asian and European Populations: A Drug-Target Mendelian Randomization Study DB Rosoff, AS Bell, LA Mavromatis, A Hamandi, L Park, J Jung, J Wagner, ... Circulation: Genomic and Precision Medicine 17 (1), e004224, 2024 | | 2024 |
PCSK9 Inhibition Attenuates Alcohol-Associated Neuronal Oxidative Stress and Neuroinflammation J Wagner, L Park, P Mukhopadhyay, J Jung, A Hamandi, P Pacher, ... NEUROPSYCHOPHARMACOLOGY 48, 414-414, 2023 | | 2023 |