xCell: digitally portraying the tissue cellular heterogeneity landscape D Aran, Z Hu, AJ Butte Genome biology 18, 1-14, 2017 | 2997 | 2017 |
Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage D Aran, AP Looney, L Liu, E Wu, V Fong, A Hsu, S Chak, RP Naikawadi, ... Nature immunology 20 (2), 163-172, 2019 | 2691 | 2019 |
The repertoire of mutational signatures in human cancer LB Alexandrov, J Kim, NJ Haradhvala, MN Huang, AW Tian Ng, Y Wu, ... Nature 578 (7793), 94-101, 2020 | 2507 | 2020 |
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 ME Patti, AJ Butte, S Crunkhorn, K Cusi, R Berria, S Kashyap, Y Miyazaki, ... Proceedings of the National Academy of Sciences 100 (14), 8466-8471, 2003 | 2417 | 2003 |
Scalable and accurate deep learning with electronic health records A Rajkomar, E Oren, K Chen, AM Dai, N Hajaj, M Hardt, PJ Liu, X Liu, ... NPJ digital medicine 1 (1), 1-10, 2018 | 2128 | 2018 |
Ten years of pathway analysis: current approaches and outstanding challenges P Khatri, M Sirota, AJ Butte PLoS computational biology 8 (2), e1002375, 2012 | 1741 | 2012 |
Pan-cancer analysis of whole genomes Nature 578 (7793), 82-93, 2020 | 1726* | 2020 |
Mutual information relevance networks: functional genomic clustering using pairwise entropy measurements AJ Butte, IS Kohane Biocomputing 2000, 418-429, 1999 | 1406 | 1999 |
Personal omics profiling reveals dynamic molecular and medical phenotypes R Chen, GI Mias, J Li-Pook-Than, L Jiang, HYK Lam, R Chen, E Miriami, ... Cell 148 (6), 1293-1307, 2012 | 1380 | 2012 |
ClinGen--the Clinical Genome Resource WMS Rehm HL, Berg JS, Brooks LD, Bustamante CD, Evans JP, Landrum MJ ... New England Journal of Medicine 372 (23), 2235-42, 2015 | 1183 | 2015 |
Variation in the human immune system is largely driven by non-heritable influences P Brodin, V Jojic, T Gao, S Bhattacharya, CJL Angel, D Furman, ... Cell 160 (1), 37-47, 2015 | 1045 | 2015 |
Systematic pan-cancer analysis of tumour purity D Aran, M Sirota, AJ Butte Nature communications 6 (1), 8971, 2015 | 1038 | 2015 |
The evolutionary history of 2,658 cancers M Gerstung, C Jolly, I Leshchiner, SC Dentro, S Gonzalez, D Rosebrock, ... Nature 578 (7793), 122-128, 2020 | 884 | 2020 |
Discovery and preclinical validation of drug indications using compendia of public gene expression data M Sirota, JT Dudley, J Kim, AP Chiang, AA Morgan, A Sweet-Cordero, ... Science translational medicine 3 (96), 96ra77-96ra77, 2011 | 866 | 2011 |
Clinical assessment incorporating a personal genome EA Ashley, AJ Butte, MT Wheeler, R Chen, TE Klein, FE Dewey, ... The Lancet 375 (9725), 1525-1535, 2010 | 807 | 2010 |
Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks AJ Butte, P Tamayo, D Slonim, TR Golub, IS Kohane Proceedings of the National Academy of Sciences 97 (22), 12182-12186, 2000 | 796 | 2000 |
The use and analysis of microarray data A Butte Nature reviews drug discovery 1 (12), 951-960, 2002 | 728 | 2002 |
Patterns of somatic structural variation in human cancer genomes Y Li, ND Roberts, JA Wala, O Shapira, SE Schumacher, K Kumar, ... Nature 578 (7793), 112-121, 2020 | 715 | 2020 |
ImmPort: disseminating data to the public for the future of immunology S Bhattacharya, S Andorf, L Gomes, P Dunn, H Schaefer, J Pontius, ... Immunologic research 58, 234-239, 2014 | 652 | 2014 |
Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease JT Dudley, M Sirota, M Shenoy, RK Pai, S Roedder, AP Chiang, ... Science translational medicine 3 (96), 96ra76-96ra76, 2011 | 644 | 2011 |