| Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair RS Williams, G Moncalian, JS Williams, Y Yamada, O Limbo, DS Shin, ... Cell 135 (1), 97-109, 2008 | 582 | 2008 |
| Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template RS Williams, JS Williams, JA Tainer Biochemistry and cell biology 85 (4), 509-520, 2007 | 580 | 2007 |
| A genetic map of the response to DNA damage in human cells M Olivieri, T Cho, A Álvarez-Quilón, K Li, MJ Schellenberg, ... Cell 182 (2), 481-496. e21, 2020 | 398 | 2020 |
| Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair RS Williams, GE Dodson, O Limbo, Y Yamada, JS Williams, G Guenther, ... Cell 139 (1), 87-99, 2009 | 393 | 2009 |
| Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1 RS Williams, R Green, JNM Glover Nature structural biology 8 (10), 838-842, 2001 | 350 | 2001 |
| Deficiency of terminal ADP‐ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease R Sharifi, R Morra, C Denise Appel, M Tallis, B Chioza, G Jankevicius, ... The EMBO journal 32 (9), 1225-1237, 2013 | 326 | 2013 |
| Interactions between BRCT repeats and phosphoproteins: tangled up in two JNM Glover, RS Williams, MS Lee Trends in biochemical sciences 29 (11), 579-585, 2004 | 269 | 2004 |
| Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1 RS Williams, MS Lee, DD Hau, JNM Glover Nature structural & molecular biology 11 (6), 519-525, 2004 | 268 | 2004 |
| The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase NK Bernstein, RS Williams, ML Rakovszky, D Cui, R Green, ... Molecular cell 17 (5), 657-670, 2005 | 264 | 2005 |
| Structure of a conjugating enzyme-ubiquitin thiolester intermediate reveals a novel role for the ubiquitin tail KS Hamilton, MJ Ellison, KR Barber, RS Williams, JT Huzil, S McKenna, ... Structure 9 (10), 897-904, 2001 | 212 | 2001 |
| Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays MS Lee, R Green, SM Marsillac, N Coquelle, RS Williams, T Yeung, ... Cancer research 70 (12), 4880-4890, 2010 | 182 | 2010 |
| ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair GJ Williams, RS Williams, JS Williams, G Moncalian, AS Arvai, O Limbo, ... Nature structural & molecular biology 18 (4), 423-431, 2011 | 180 | 2011 |
| ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling RA Deshpande, GJ Williams, O Limbo, RS Williams, J Kuhnlein, JH Lee, ... Embo J 33 (5), 482-500, 2014 | 161 | 2014 |
| ZATT (ZNF451)–mediated resolution of topoisomerase 2 DNA-protein cross-links MJ Schellenberg, JA Lieberman, A Herrero-Ruiz, LR Butler, JG Williams, ... Science 357 (6358), 1412-1416, 2017 | 160 | 2017 |
| Detection of protein folding defects caused by BRCA1-BRCT truncation and missense mutations RS Williams, DI Chasman, DD Hau, B Hui, AY Lau, JNM Glover Journal of Biological Chemistry 278 (52), 53007-53016, 2003 | 157 | 2003 |
| Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2· DNA and Top2· RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2) R Gao, MJ Schellenberg, NH Shar-yin, M Abdelmalak, C Marchand, ... Journal of Biological Chemistry 289 (26), 17960-17969, 2014 | 137 | 2014 |
| Structural consequences of a cancer-causing BRCA1-BRCT missense mutation RS Williams, JNM Glover Journal of Biological Chemistry 278 (4), 2630-2635, 2003 | 129 | 2003 |
| Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity P Tumbale, JS Williams, MJ Schellenberg, TA Kunkel, RS Williams Nature 506 (7486), 111-115, 2014 | 111 | 2014 |
| Endogenous DNA 3′ blocks are vulnerabilities for BRCA1 and BRCA2 deficiency and are reversed by the APE2 nuclease A Álvarez-Quilón, JL Wojtaszek, MC Mathieu, T Patel, CD Appel, ... Molecular Cell 78 (6), 1152-1165. e8, 2020 | 98 | 2020 |
| Recognition and repair of chemically heterogeneous structures at DNA ends SN Andres, MJ Schellenberg, BD Wallace, P Tumbale, RS Williams Environmental and molecular mutagenesis 56 (1), 1-21, 2015 | 93 | 2015 |
John TainerDirector of Structural Biology, Professor at MD Anderson Cancer Center & Lawrence Berkeley Lab在 mdanderson.org 的电子邮件经过验证
