| Structure and stability changes of human IgG1 Fc as a consequence of methionine oxidation D Liu, D Ren, H Huang, J Dankberg, R Rosenfeld, MJ Cocco, L Li, ... Biochemistry 47 (18), 5088-5100, 2008 | 292 | 2008 |
| Dissociation of the peptide bond in protonated peptides MJ Polce, D Ren, C Wesdemiotis Journal of Mass Spectrometry 35 (12), 1391-1398, 2000 | 223 | 2000 |
| An improved trypsin digestion method minimizes digestion-induced modifications on proteins D Ren, GD Pipes, D Liu, LY Shih, AC Nichols, MJ Treuheit, DN Brems, ... Analytical biochemistry 392 (1), 12-21, 2009 | 217 | 2009 |
| Discovery and Characterization of a Photo-Oxidative Histidine-Histidine Cross-Link in IgG1 Antibody Utilizing 18O-Labeling and Mass Spectrometry M Liu, Z Zhang, J Cheetham, D Ren, ZS Zhou Analytical chemistry 86 (10), 4940-4948, 2014 | 119 | 2014 |
| Protein Isoaspartate Methyltransferase-Mediated 18O-Labeling of Isoaspartic Acid for Mass Spectrometry Analysis M Liu, J Cheetham, N Cauchon, J Ostovic, W Ni, D Ren, ZS Zhou Analytical chemistry 84 (2), 1056-1062, 2012 | 94 | 2012 |
| Reversed-phase liquid chromatography–mass spectrometry of site-specific chemical modifications in intact immunoglobulin molecules and their fragments D Ren, G Pipes, G Xiao, GR Kleemann, PV Bondarenko, MJ Treuheit, ... Journal of Chromatography A 1179 (2), 198-204, 2008 | 85 | 2008 |
| Screening and sequencing of glycated proteins by neutral loss scan LC/MS/MS method HS Gadgil, PV Bondarenko, MJ Treuheit, D Ren Analytical chemistry 79 (15), 5991-5999, 2007 | 84 | 2007 |
| Discovery of Undefined Protein Cross-Linking Chemistry: A Comprehensive Methodology Utilizing 18O-Labeling and Mass Spectrometry M Liu, Z Zhang, T Zang, C Spahr, J Cheetham, D Ren, ZS Zhou Analytical chemistry 85 (12), 5900-5908, 2013 | 77 | 2013 |
| Cell line profiling to improve monoclonal antibody production S Kang, D Ren, G Xiao, K Daris, L Buck, AA Enyenihi, R Zubarev, ... Biotechnology and bioengineering 111 (4), 748-760, 2014 | 71 | 2014 |
| Detection of trace melamine in raw materials used for protein pharmaceutical manufacturing using surface-enhanced Raman spectroscopy (SERS) with gold nanoparticles ZQ Wen, G Li, D Ren Applied Spectroscopy 65 (5), 514-521, 2011 | 62 | 2011 |
| Elucidation of degradants in acidic peak of cation exchange chromatography in an IgG1 monoclonal antibody formed on long-term storage in a liquid formulation S Gandhi, D Ren, G Xiao, P Bondarenko, C Sloey, MS Ricci, S Krishnan Pharmaceutical research 29, 209-224, 2012 | 56 | 2012 |
| Top-down N-terminal sequencing of Immunoglobulin subunits with electrospray ionization time of flight mass spectrometry D Ren, GD Pipes, D Hambly, PV Bondarenko, MJ Treuheit, HS Gadgil Analytical biochemistry 384 (1), 42-48, 2009 | 38 | 2009 |
| Advancing mass spectrometry technology in cGMP environments D Ren Trends in Biotechnology 38 (10), 1051-1053, 2020 | 37 | 2020 |
| New peak detection performance metrics from the MAM consortium interlaboratory study T Mouchahoir, JE Schiel, R Rogers, A Heckert, BJ Place, A Ammerman, ... Journal of the American Society for Mass Spectrometry 32 (4), 913-928, 2021 | 35 | 2021 |
| Interactions between therapeutic proteins and acrylic acid leachable D Liu, Y Nashed-Samuel, PV Bondarenko, DN Brems, D Ren PDA Journal of Pharmaceutical Science and Technology 66 (1), 12-19, 2012 | 32 | 2012 |
| Reversed-phase liquid chromatography of immunoglobulin G molecules and their fragments with the diphenyl column D Ren, GD Pipes, DM Hambly, PV Bondarenko, MJ Treuheit, DN Brems, ... Journal of Chromatography A 1175 (1), 63-68, 2007 | 29 | 2007 |
| Chemical modifications of therapeutic proteins induced by residual ethylene oxide L Chen, C Sloey, Z Zhang, PV Bondarenko, H Kim Journal of pharmaceutical sciences 104 (2), 731-739, 2015 | 23 | 2015 |
| A high-resolution multi-attribute method for product characterization, process characterization, and quality control of therapeutic proteins X Guan, T Eris, L Zhang, D Ren, MS Ricci, T Thiel, CT Goudar Analytical Biochemistry 643, 114575, 2022 | 18 | 2022 |
| Degradation products analysis of an Fc fusion protein using LC/MS methods D Ren, G Ratnaswamy, J Beierle, MJ Treuheit, DN Brems, ... International journal of biological macromolecules 44 (1), 81-85, 2009 | 18 | 2009 |
| Comprehensive multi-attribute method workflow for biotherapeutic characterization and current good manufacturing practices testing S Millán-Martín, C Jakes, S Carillo, R Rogers, D Ren, J Bones Nature Protocols 18 (4), 1056-1089, 2023 | 15 | 2023 |
