| Biosynthetic capacity, metabolic variety and unusual biology in the CPR and DPANN radiations CJ Castelle, CT Brown, K Anantharaman, AJ Probst, RH Huang, ... Nature Reviews Microbiology 16 (10), 629-645, 2018 | 369 | 2018 |
| Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate W Xie, X Liu, RH Huang Nature Structural & Molecular Biology 10 (10), 781-788, 2003 | 149 | 2003 |
| Archaeal Elp3 catalyzes tRNA wobble uridine modification at C5 via a radical mechanism K Selvadurai, P Wang, J Seimetz, RH Huang Nature chemical biology 10 (10), 810-812, 2014 | 119 | 2014 |
| Reconstituting bacterial RNA repair and modification in vitro CM Chan, C Zhou, RH Huang Science 326 (5950), 247-247, 2009 | 83 | 2009 |
| Crystallographic snapshots of eukaryotic dimethylallyltransferase acting on tRNA: insight into tRNA recognition and reaction mechanism C Zhou, RH Huang Proceedings of the National Academy of Sciences 105 (42), 16142-16147, 2008 | 69 | 2008 |
| Conformational change of pseudouridine 55 synthase upon its association with RNA substrate K Phannachet, RH Huang Nucleic acids research 32 (4), 1422-1429, 2004 | 65 | 2004 |
| Biochemical and Structural Studies of A-to-I Editing by tRNA:A34 Deaminases at the Wobble Position of Transfer RNA, Y Elias, RH Huang Biochemistry 44 (36), 12057-12065, 2005 | 61 | 2005 |
| Dissecting the roles of a strictly conserved tyrosine in substrate recognition and catalysis by pseudouridine 55 synthase K Phannachet, Y Elias, RH Huang Biochemistry 44 (47), 15488-15494, 2005 | 55 | 2005 |
| Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′, 2′-cGAMP as the second messenger S Fatma, A Chakravarti, X Zeng, RH Huang Nature communications 12 (1), 6381, 2021 | 54 | 2021 |
| Structural and biochemical insights into 2′-O-methylation at the 3′-terminal nucleotide of RNA by Hen1 C Mui Chan, C Zhou, JS Brunzelle, RH Huang Proceedings of the National Academy of Sciences 106 (42), 17699-17704, 2009 | 50 | 2009 |
| Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors LL Jones, LA Colf, AJ Bankovich, JD Stone, YG Gao, CM Chan, ... Biochemistry 47 (47), 12398-12408, 2008 | 36 | 2008 |
| Unique 2′-O-methylation by Hen1 in eukaryotic RNA interference and bacterial RNA repair RH Huang Biochemistry 51 (20), 4087-4095, 2012 | 33 | 2012 |
| Structural and Mutational Studies of the Catalytic Domain of Colicin E5: A tRNA-Specific Ribonuclease, YL Lin, Y Elias, RH Huang Biochemistry 44 (31), 10494-10500, 2005 | 32 | 2005 |
| Structure of tRNA dimethylallyltransferase: RNA modification through a channel W Xie, C Zhou, RH Huang Journal of molecular biology 367 (3), 872-881, 2007 | 30 | 2007 |
| Double methylation of tRNA-U54 to 2′-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7 P Keller, I Freund, V Marchand, G Bec, R Huang, Y Motorin, T Eigenbrod, ... Nucleic acids research 46 (18), 9764-9775, 2018 | 25 | 2018 |
| Crystal structure of QueC from Bacillus subtilis: An enzyme involved in preQ1 biosynthesis N Cicmil, RH Huang Proteins: Structure, Function, and Bioinformatics 72 (3), 1084-1088, 2008 | 25 | 2008 |
| Molecular basis of inhibition of the ribonuclease activity in colicin E5 by its cognate immunity protein C Luna-Chávez, YL Lin, RH Huang Journal of molecular biology 358 (2), 571-579, 2006 | 20 | 2006 |
| Reconstitution and substrate specificity for isopentenyl pyrophosphate of the antiviral radical SAM enzyme viperin A Chakravarti, K Selvadurai, R Shahoei, H Lee, S Fatma, E Tajkhorshid, ... Journal of Biological Chemistry 293 (36), 14122-14133, 2018 | 19 | 2018 |
| Reconstitution and structure of a bacterial Pnkp1–Rnl–Hen1 RNA repair complex P Wang, K Selvadurai, RH Huang Nature communications 6 (1), 6876, 2015 | 16 | 2015 |
| Enzymatic characterization and mutational studies of TruD–the fifth family of pseudouridine synthases CM Chan, RH Huang Archives of biochemistry and biophysics 489 (1-2), 15-19, 2009 | 14 | 2009 |
