Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice P Langfelder, JP Cantle, D Chatzopoulou, N Wang, F Gao, I Al-Ramahi, ... Nature neuroscience 19 (4), 623-633, 2016 | 379 | 2016 |
Elevated TREM2 gene dosage reprograms microglia responsivity and ameliorates pathological phenotypes in Alzheimer’s disease models CYD Lee, A Daggett, X Gu, LL Jiang, P Langfelder, X Li, N Wang, Y Zhao, ... Neuron 97 (5), 1032-1048. e5, 2018 | 360 | 2018 |
Assembly and function of heterotypic ubiquitin chains in cell-cycle and protein quality control RG Yau, K Doerner, ER Castellanos, DL Haakonsen, A Werner, N Wang, ... Cell 171 (4), 918-933. e20, 2017 | 310 | 2017 |
Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease N Wang, M Gray, XH Lu, JP Cantle, SM Holley, E Greiner, X Gu, ... Nature medicine 20 (5), 536-541, 2014 | 210 | 2014 |
An antisense CAG repeat transcript at JPH3 locus mediates expanded polyglutamine protein toxicity in Huntington's disease-like 2 mice B Wilburn, DD Rudnicki, J Zhao, TM Weitz, Y Cheng, X Gu, E Greiner, ... Neuron 70 (3), 427-440, 2011 | 158 | 2011 |
Universal DNA methylation age across mammalian tissues AT Lu, Z Fei, A Haghani, TR Robeck, JA Zoller, CZ Li, R Lowe, Q Yan, ... Nature aging 3 (9), 1144-1166, 2023 | 153 | 2023 |
Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington’s disease XH Lu, VB Mattis, N Wang, I Al-Ramahi, N van den Berg, SA Fratantoni, ... Science translational medicine 6 (268), 268ra178-268ra178, 2014 | 140 | 2014 |
Universal DNA methylation age across mammalian tissues AT Lu, Z Fei, A Haghani, TR Robeck, JA Zoller, CZ Li, R Lowe, Q Yan, ... BioRxiv, 2021.01. 18.426733, 2021 | 104 | 2021 |
DNA methylation networks underlying mammalian traits A Haghani, CZ Li, TR Robeck, J Zhang, AT Lu, J Ablaeva, ... Science 381 (6658), eabq5693, 2023 | 66 | 2023 |
DNA methylation study of Huntington’s disease and motor progression in patients and in animal models AT Lu, P Narayan, MJ Grant, P Langfelder, N Wang, S Kwak, H Wilkinson, ... Nature communications 11 (1), 4529, 2020 | 63 | 2020 |
Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci VJ Sugrue, JA Zoller, P Narayan, AT Lu, OJ Ortega-Recalde, MJ Grant, ... Elife 10, e64932, 2021 | 61 | 2021 |
MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice P Langfelder, F Gao, N Wang, D Howland, S Kwak, TF Vogt, JS Aaronson, ... PloS one 13 (1), e0190550, 2018 | 52 | 2018 |
Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice X Gu, J Richman, P Langfelder, N Wang, S Zhang, M Bañez-Coronel, ... Neuron 110 (7), 1173-1192. e7, 2022 | 36 | 2022 |
m1A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration Y Sun, H Dai, X Dai, J Yin, Y Cui, X Liu, G Gonzalez, J Yuan, F Tang, ... Nature 623 (7987), 580-587, 2023 | 25 | 2023 |
CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington’s disease S Picó, A Parras, M Santos-Galindo, J Pose-Utrilla, M Castro, E Fraga, ... Science Translational Medicine 13 (613), eabe7104, 2021 | 23 | 2021 |
Epigenetic predictors of maximum lifespan and other life history traits in mammals CZ Li, A Haghani, TR Robeck, D Villar, AT Lu, J Zhang, CG Faulkes, H Vu, ... BioRxiv, 2021.05. 16.444078, 2021 | 19 | 2021 |
Disease-related Huntingtin seeding activities in cerebrospinal fluids of Huntington’s disease patients CYD Lee, N Wang, K Shen, M Stricos, P Langfelder, KH Cheon, ... Scientific Reports 10 (1), 20295, 2020 | 16 | 2020 |
An independent study of the preclinical efficacy of C2-8 in the R6/2 transgenic mouse model of Huntington's disease N Wang, XH Lu, SV Sandoval, XW Yang Journal of Huntington's disease 2 (4), 443-451, 2013 | 15 | 2013 |
Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures N Wang, P Langfelder, M Stricos, L Ramanathan, JB Richman, R Vaca, ... Neuron 110 (20), 3318-3338. e9, 2022 | 11 | 2022 |
Huntington disease’s glial progenitor cells hit the pause button in the mouse brain N Wang, XW Yang Cell Stem Cell 24 (1), 3-4, 2019 | 8 | 2019 |