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Succinate is an inflammatory signal that induces IL-1β through HIF-1α GM Tannahill, AM Curtis, J Adamik, EM Palsson-McDermott, ... Nature 496 (7444), 238-242, 2013 | 3507 | 2013 |
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS ET Chouchani, VR Pell, E Gaude, D Aksentijević, SY Sundier, EL Robb, ... Nature 515 (7527), 431-435, 2014 | 2501 | 2014 |
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion C Frezza, S Cipolat, OM De Brito, M Micaroni, GV Beznoussenko, ... Cell 126 (1), 177-189, 2006 | 1822 | 2006 |
Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages EL Mills, B Kelly, A Logan, ASH Costa, M Varma, CE Bryant, ... Cell 167 (2), 457-470. e13, 2016 | 1736 | 2016 |
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ... Nature 556 (7699), 113-117, 2018 | 1336 | 2018 |
Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts C Frezza, S Cipolat, L Scorrano Nature protocols 2 (2), 287-295, 2007 | 1282 | 2007 |
Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency S Cogliati, C Frezza, ME Soriano, T Varanita, R Quintana-Cabrera, ... Cell 155 (1), 160-171, 2013 | 1206 | 2013 |
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling S Cipolat, T Rudka, D Hartmann, V Costa, L Serneels, K Craessaerts, ... Cell 126 (1), 163-175, 2006 | 853 | 2006 |
A unifying mechanism for mitochondrial superoxide production during ischemia-reperfusion injury ET Chouchani, VR Pell, AM James, LM Work, K Saeb-Parsy, C Frezza, ... Cell metabolism 23 (2), 254-263, 2016 | 686 | 2016 |
Serine is a natural ligand and allosteric activator of pyruvate kinase M2 B Chaneton, P Hillmann, L Zheng, ACL Martin, ODK Maddocks, ... Nature 491 (7424), 458-462, 2012 | 665 | 2012 |
A roadmap for interpreting 13C metabolite labeling patterns from cells JM Buescher, MR Antoniewicz, LG Boros, SC Burgess, H Brunengraber, ... Current opinion in biotechnology 34, 189-201, 2015 | 621 | 2015 |
Predicting selective drug targets in cancer through metabolic networks O Folger, L Jerby, C Frezza, E Gottlieb, E Ruppin, T Shlomi Molecular systems biology 7 (1), 501, 2011 | 589 | 2011 |
Serine is an essential metabolite for effector T cell expansion EH Ma, G Bantug, T Griss, S Condotta, RM Johnson, B Samborska, ... Cell metabolism 25 (2), 345-357, 2017 | 578 | 2017 |
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase C Frezza, L Zheng, O Folger, KN Rajagopalan, ED MacKenzie, L Jerby, ... Nature 477 (7363), 225-228, 2011 | 548 | 2011 |
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition M Sciacovelli, E Gonçalves, TI Johnson, VR Zecchini, ASH Da Costa, ... Nature 537 (7621), 544-547, 2016 | 529 | 2016 |
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function VA Morais, P Verstreken, A Roethig, J Smet, A Snellinx, M Vanbrabant, ... EMBO molecular medicine 1 (2), 99-111, 2009 | 453 | 2009 |
Mitochondria in cancer: not just innocent bystanders C Frezza, E Gottlieb Seminars in cancer biology 19 (1), 4-11, 2009 | 350 | 2009 |
Coupling Krebs cycle metabolites to signalling in immunity and cancer DG Ryan, MP Murphy, C Frezza, HA Prag, ET Chouchani, LA O’Neill, ... Nature metabolism 1 (1), 16-33, 2019 | 326 | 2019 |
Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival E Gaude, C Frezza Nature communications 7 (1), 13041, 2016 | 326 | 2016 |