| The productive conformation of arachidonic acid bound to prostaglandin synthase MG Malkowski, SL Ginell, WL Smith, RM Garavito Science 289 (5486), 1933-1937, 2000 | 369 | 2000 |
| The structures of prostaglandin endoperoxide H synthases-1 and-2 RM Garavito, MG Malkowski, DL DeWitt Prostaglandins & other lipid mediators 68, 129-152, 2002 | 228 | 2002 |
| Crystal structure of aspirin-acetylated human cyclooxygenase-2: insight into the formation of products with reversed stereochemistry MJ Lucido, BJ Orlando, AJ Vecchio, MG Malkowski Biochemistry 55 (8), 1226-1238, 2016 | 220 | 2016 |
| Pleiotropic mechanisms facilitated by resveratrol and its metabolites B Calamini, K Ratia, MG Malkowski, M Cuendet, JM Pezzuto, ... Biochemical Journal 429 (2), 273-282, 2010 | 218 | 2010 |
| Substrate-selective inhibition of cyclooxygeanse-2 by fenamic acid derivatives is dependent on peroxide tone BJ Orlando, MG Malkowski Journal of Biological Chemistry 291 (29), 15069-15081, 2016 | 194 | 2016 |
| Structural basis of fatty acid substrate binding to cyclooxygenase-2 AJ Vecchio, DM Simmons, MG Malkowski Journal of Biological Chemistry 285 (29), 22152-22163, 2010 | 184 | 2010 |
| The structure of ibuprofen bound to cyclooxygenase-2 BJ Orlando, MJ Lucido, MG Malkowski Journal of structural biology 189 (1), 62-66, 2015 | 177 | 2015 |
| Prostaglandin Endoperoxide H Synthase-1: THE FUNCTIONS OF CYCLOOXYGENASE ACTIVE SITE RESIDUES IN THE BINDING, POSITIONING, AND OXYGENATION OF ARACHIDONIC ACID* 210 ED Thuresson, KM Lakkides, CJ Rieke, Y Sun, BA Wingerd, R Micielli, ... Journal of Biological Chemistry 276 (13), 10347-10357, 2001 | 176 | 2001 |
| Crystal structure of rofecoxib bound to human cyclooxygenase-2 BJ Orlando, MG Malkowski Acta Crystallographica Section F: Structural Biology Communications 72 (10 …, 2016 | 165 | 2016 |
| Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1 MG Malkowski, ED Thuresson, KM Lakkides, CJ Rieke, R Micielli, ... Journal of Biological Chemistry 276 (40), 37547-37555, 2001 | 153 | 2001 |
| Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer L Dong, AJ Vecchio, NP Sharma, BJ Jurban, MG Malkowski, WL Smith Journal of Biological Chemistry 286 (21), 19035-19046, 2011 | 124 | 2011 |
| Structure of the integral membrane protein CAAX protease Ste24p EE Pryor Jr, PS Horanyi, KM Clark, N Fedoriw, SM Connelly, ... Science 339 (6127), 1600-1604, 2013 | 115 | 2013 |
| The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-Å resolution MG Malkowski, JY Wu, JB Lazar, PH Johnson, BFP Edwards Journal of Biological Chemistry 270 (13), 7077-7087, 1995 | 102 | 1995 |
| New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK PD Martin, MG Malkowski, J Box, CT Esmon, BFP Edwards Structure 5 (12), 1681-1693, 1997 | 76 | 1997 |
| Efficient optimization of crystallization conditions by manipulation of drop volume ratio and temperature JR Luft, JR Wolfley, MI Said, RM Nagel, AM Lauricella, JL Smith, ... Protein science 16 (4), 715-722, 2007 | 75 | 2007 |
| Coordinating the impact of structural genomics on the human α-helical transmembrane proteome U Pieper, A Schlessinger, E Kloppmann, GA Chang, JJ Chou, ME Dumont, ... Nature structural & molecular biology 20 (2), 135-138, 2013 | 74 | 2013 |
| The crystal structure of an integral membrane fatty acid α-hydroxylase G Zhu, M Koszelak-Rosenblum, SM Connelly, ME Dumont, MG Malkowski Journal of Biological Chemistry 290 (50), 29820-29833, 2015 | 67 | 2015 |
| The structure of a complex of bovine alpha-thrombin and recombinant hirudin at 2.8-A resolution. J Vitali, PD Martin, MG Malkowski, WD Robertson, JB Lazar, RC Winant, ... Journal of Biological Chemistry 267 (25), 17670-17678, 1992 | 65 | 1992 |
| Mutational and x-ray crystallographic analysis of the interaction of dihomo-γ-linolenic acid with prostaglandin endoperoxide H synthases ED Thuresson, MG Malkowski, KM Lakkides, CJ Rieke, AM Mulichak, ... Journal of Biological Chemistry 276 (13), 10358-10365, 2001 | 61 | 2001 |
| Investigating substrate promiscuity in cyclooxygenase-2: the role of Arg-120 and residues lining the hydrophobic groove AJ Vecchio, BJ Orlando, R Nandagiri, MG Malkowski Journal of Biological Chemistry 287 (29), 24619-24630, 2012 | 59 | 2012 |
