Histone deacetylase 6 inhibits influenza A virus release by downregulating the trafficking of viral components to the plasma membrane via its substrate, acetylated microtubules M Husain, CY Cheung Journal of virology 88 (19), 11229-11239, 2014 | 101 | 2014 |
Pyrazolo[1,5-a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis X Lu, Z Williams, K Hards, J Tang, CY Cheung, HL Aung, B Wang, Z Liu, ... ACS infectious diseases 5 (2), 239-249, 2018 | 81 | 2018 |
6-Substituted hexamethylene amiloride (HMA) derivatives as potent and selective inhibitors of the human urokinase plasminogen activator for use in cancer BJ Buckley, A Aboelela, E Minaei, LX Jiang, Z Xu, U Ali, K Fildes, ... Journal of medicinal chemistry 61 (18), 8299-8320, 2018 | 62 | 2018 |
Activation of type II NADH dehydrogenase by quinolinequinones mediates antitubercular cell death A Heikal, K Hards, CY Cheung, A Menorca, MSM Timmer, BL Stocker, ... Journal of Antimicrobial Chemotherapy 71 (10), 2840-2847, 2016 | 48 | 2016 |
Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis WG Saw, ML Wu, P Ragunathan, G Biuković, AM Lau, J Shin, ... Scientific reports 9 (1), 16759, 2019 | 35 | 2019 |
Inhalable dry powder of bedaquiline for pulmonary tuberculosis: In vitro physicochemical characterization, antimicrobial activity and safety studies MAM Momin, B Rangnekar, S Sinha, CY Cheung, GM Cook, SC Das Pharmaceutics 11 (10), 502, 2019 | 33 | 2019 |
CRISPR interference identifies vulnerable cellular pathways with bactericidal phenotypes in Mycobacterium tuberculosis MB McNeil, LM Keighley, JR Cook, CY Cheung, GM Cook Molecular microbiology 116 (4), 1033-1043, 2021 | 28 | 2021 |
The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis NJE Waller, CY Cheung, GM Cook, MB McNeil Nature Communications 14 (1), 1517, 2023 | 27 | 2023 |
Two for the price of one: Attacking the energetic-metabolic hub of mycobacteria to produce new chemotherapeutic agents K Hards, C Adolph, LK Harold, MB McNeil, CY Cheung, A Jinich, ... Progress in biophysics and molecular biology 152, 35-44, 2020 | 26 | 2020 |
Development of multiwell-plate methods using pure cultures of methanogens to identify new inhibitors for suppressing ruminant methane emissions MR Weimar, J Cheung, D Dey, C McSweeney, M Morrison, Y Kobayashi, ... Applied and Environmental Microbiology 83 (15), e00396-17, 2017 | 26 | 2017 |
An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis K Hards, CY Cheung, N Waller, C Adolph, L Keighley, ZS Tee, LK Harold, ... Communications Biology 5 (1), 166, 2022 | 24 | 2022 |
The synthesis and evaluation of quinolinequinones as anti-mycobacterial agents KT Santoso, A Menorca, CY Cheung, GM Cook, BL Stocker, MSM Timmer Bioorganic & medicinal chemistry 27 (16), 3532-3545, 2019 | 23 | 2019 |
Discovery of Cephalosporin-3′-Diazeniumdiolates That Show Dual Antibacterial and Antibiofilm Effects against Pseudomonas aeruginosa Clinical Cystic Fibrosis … A Rineh, O Soren, T McEwan, V Ravikumar, WH Poh, F Azamifar, ... ACS infectious diseases 6 (6), 1460-1479, 2020 | 22 | 2020 |
6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease BJ Buckley, H Majed, A Aboelela, E Minaei, L Jiang, K Fildes, CY Cheung, ... Bioorganic & medicinal chemistry letters 29 (24), 126753, 2019 | 21 | 2019 |
Potent bactericidal antimycobacterials targeting the chaperone ClpC1 based on the depsipeptide natural products ecumicin and ohmyungsamycin A PME Hawkins, DM Hoi, CY Cheung, T Wang, D Quan, VM Sasi, DY Liu, ... Journal of medicinal chemistry 65 (6), 4893-4908, 2022 | 13 | 2022 |
Synthesis and investigation of phthalazinones as antitubercular agents KT Santoso, CY Cheung, K Hards, GM Cook, BL Stocker, MSM Timmer Chemistry–An Asian Journal 14 (8), 1278-1285, 2019 | 12 | 2019 |
Multiplexed transcriptional repression identifies a network of bactericidal interactions between mycobacterial respiratory complexes MB McNeil, HW Ryburn, J Tirados, CY Cheung, GM Cook Iscience 25 (1), 2022 | 10 | 2022 |
Synthetic Sansanmycin Analogues as Potent Mycobacterium tuberculosis Translocase I Inhibitors W Tran, AS Kusay, PME Hawkins, CY Cheung, G Nagalingam, V Pujari, ... Journal of medicinal chemistry 64 (23), 17326-17345, 2021 | 10 | 2021 |
Total synthesis and antimycobacterial activity of ohmyungsamycin A, deoxyecumicin, and ecumicin PME Hawkins, W Tran, G Nagalingam, CY Cheung, AM Giltrap, GM Cook, ... Chemistry–A European Journal 26 (66), 15200-15205, 2020 | 10 | 2020 |
Utilization of CRISPR interference to investigate the contribution of genes to pathogenesis in a macrophage model of Mycobacterium tuberculosis infection CY Cheung, MB McNeil, GM Cook Journal of Antimicrobial Chemotherapy 77 (3), 615-619, 2022 | 9 | 2022 |