| Analysis of past and present synthetic methodologies on medicinal chemistry: where have all the new reactions gone? Miniperspective DG Brown, J Bostrom Journal of medicinal chemistry 59 (10), 4443-4458, 2016 | 1544 | 2016 |
| ESKAPEing the labyrinth of antibacterial discovery R Tommasi, DG Brown, GK Walkup, JI Manchester, AA Miller Nature reviews Drug discovery 14 (8), 529-542, 2015 | 634 | 2015 |
| Expanding the medicinal chemistry synthetic toolbox J Boström, DG Brown, RJ Young, GM Keserü Nature Reviews Drug Discovery 17 (10), 709-727, 2018 | 542 | 2018 |
| Impact of a five-dimensional framework on R&D productivity at AstraZeneca P Morgan, DG Brown, S Lennard, MJ Anderton, JC Barrett, U Eriksson, ... Nature reviews Drug discovery 17 (3), 167-181, 2018 | 388 | 2018 |
| Structural insight into allosteric modulation of protease-activated receptor 2 RKY Cheng, C Fiez-Vandal, O Schlenker, K Edman, B Aggeler, DG Brown, ... Nature 545 (7652), 112-115, 2017 | 245 | 2017 |
| New natural products as new leads for antibacterial drug discovery DG Brown, T Lister, TL May-Dracka Bioorganic & medicinal chemistry letters 24 (2), 413-418, 2014 | 237 | 2014 |
| Trends and exceptions of physical properties on antibacterial activity for Gram-positive and Gram-negative pathogens DG Brown, TL May-Dracka, MM Gagnon, R Tommasi Journal of medicinal chemistry 57 (23), 10144-10161, 2014 | 236 | 2014 |
| A decade of FDA-approved drugs (2010–2019): trends and future directions DG Brown, HJ Wobst Journal of medicinal chemistry 64 (5), 2312-2338, 2021 | 205 | 2021 |
| Where do recent small molecule clinical development candidates come from? DG Brown, J Boström Journal of medicinal chemistry 61 (21), 9442-9468, 2018 | 172 | 2018 |
| A convenient synthesis of dimethyl (diazomethyl) phosphonate (Seyferth/Gilbert reagent) DG Brown, EJ Velthuisen, JR Commerford, RG Brisbois, TR Hoye The Journal of Organic Chemistry 61 (7), 2540-2541, 1996 | 144 | 1996 |
| Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons MC Silva, GA Nandi, S Tentarelli, IK Gurrell, T Jamier, D Lucente, ... Nature Communications 11 (1), 3258, 2020 | 115 | 2020 |
| Novel antibacterial targets and compounds revealed by a high-throughput cell wall reporter assay AS Nayar, TJ Dougherty, KE Ferguson, BA Granger, L McWilliams, ... Journal of bacteriology 197 (10), 1726-1734, 2015 | 103 | 2015 |
| Clinical development times for innovative drugs DG Brown, HJ Wobst, A Kapoor, LA Kenna, N Southall Nat Rev Drug Discov 21 (11), 793-794, 2022 | 101 | 2022 |
| The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future HJ Wobst, KL Mack, DG Brown, NJ Brandon, J Shorter Medicinal research reviews 40 (4), 1352-1384, 2020 | 74 | 2020 |
| Acute pharmacological modulation of mGluR8 reduces measures of anxiety RM Duvoisin, T Pfankuch, JM Wilson, J Grabell, V Chhajlani, DG Brown, ... Behavioural brain research 212 (2), 168-173, 2010 | 74 | 2010 |
| Discovery of a potent respiratory syncytial virus RNA polymerase inhibitor H Xiong, M Foulk, L Aschenbrenner, J Fan, CL Tiong-Yip, KD Johnson, ... Bioorganic & medicinal chemistry letters 23 (24), 6789-6793, 2013 | 71 | 2013 |
| CETSA beyond soluble targets: a broad application to multipass transmembrane proteins A Kawatkar, M Schefter, NO Hermansson, A Snijder, N Dekker, DG Brown, ... ACS chemical biology 14 (9), 1913-1920, 2019 | 66 | 2019 |
| Understanding Our Love Affair with p-Chlorophenyl: Present Day Implications from Historical Biases of Reagent Selection DG Brown, MM Gagnon, J Bostrom Journal of Medicinal Chemistry 58 (5), 2390-2405, 2015 | 66 | 2015 |
| N-methyl-D-aspartate receptor (NMDA) antagonists as potential pain therapeutics DG Brown, JJ Krupp Current Topics in Medicinal Chemistry 6 (8), 749-770, 2006 | 59 | 2006 |
| DNA strand breaks and hypoxia response inhibition mediate the radiosensitisation effect of nitric oxide donors on prostate cancer under varying oxygen conditions GD Stewart, J Nanda, E Katz, KJ Bowman, JG Christie, DJG Brown, ... Biochemical pharmacology 81 (2), 203-210, 2011 | 50 | 2011 |
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