| Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency C Schindler, A Collinson, C Matthews, A Pointon, L Jenkinson, RR Minter, ... PloS one 14 (3), e0214545, 2019 | 148 | 2019 |
| Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation AV Pointon, TM Walker, KM Phillips, J Luo, J Riley, SD Zhang, JD Parry, ... PloS one 5 (9), e12733, 2010 | 132 | 2010 |
| Cardiac non-myocyte cells show enhanced pharmacological function suggestive of contractile maturity in stem cell derived cardiomyocyte microtissues SM Ravenscroft, A Pointon, AW Williams, MJ Cross, JE Sidaway Toxicological Sciences 152 (1), 99-112, 2016 | 127 | 2016 |
| Application of microphysiological systems to enhance safety assessment in drug discovery L Ewart, EM Dehne, K Fabre, S Gibbs, J Hickman, E Hornberg, ... Annual review of pharmacology and toxicology 58 (1), 65-82, 2018 | 120 | 2018 |
| Characterization and validation of a human 3D cardiac microtissue for the assessment of changes in cardiac pathology CR Archer, R Sargeant, J Basak, J Pilling, JR Barnes, A Pointon Scientific reports 8 (1), 10160, 2018 | 113 | 2018 |
| Assessment of cardiomyocyte contraction in human-induced pluripotent stem cell-derived cardiomyocytes A Pointon, AR Harmer, IL Dale, N Abi-Gerges, J Bowes, C Pollard, ... Toxicological sciences 144 (2), 227-237, 2015 | 113 | 2015 |
| Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity A Pointon, N Abi-Gerges, MJ Cross, JE Sidaway toxicological sciences 132 (2), 317-326, 2013 | 88 | 2013 |
| On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships CW McAleer, A Pointon, CJ Long, RL Brighton, BD Wilkin, LR Bridges, ... Scientific reports 9 (1), 9619, 2019 | 83 | 2019 |
| From the cover: high-throughput imaging of cardiac microtissues for the assessment of cardiac contraction during drug discovery A Pointon, J Pilling, T Dorval, Y Wang, C Archer, C Pollard Toxicological Sciences 155 (2), 444-457, 2017 | 76 | 2017 |
| Time for a fully integrated nonclinical–clinical risk assessment to streamline QT prolongation liability determinations: A pharma industry perspective HM Vargas, MG Rolf, TA Wisialowski, W Achanzar, A Bahinski, A Bass, ... Clinical Pharmacology & Therapeutics 109 (2), 310-318, 2021 | 60 | 2021 |
| Cytochrome P450 2J2: potential role in drug metabolism and cardiotoxicity M Solanki, A Pointon, B Jones, K Herbert Drug Metabolism and Disposition 46 (8), 1053-1065, 2018 | 53 | 2018 |
| Enhanced characterization of contractility in cardiomyocytes during early drug safety assessment L Butler, C Cros, KL Oldman, AR Harmer, A Pointon, CE Pollard, ... Toxicological Sciences 145 (2), 396-406, 2015 | 49 | 2015 |
| Assessment of extracellular field potential and Ca2+ transient signals for early QT/pro-arrhythmia detection using human induced pluripotent stem cell-derived cardiomyocytes N Abi-Gerges, A Pointon, KL Oldman, MR Brown, MA Pilling, CE Sefton, ... Journal of pharmacological and toxicological methods 83, 1-15, 2017 | 37 | 2017 |
| Preservation of cardiomyocytes from the adult heart N Abi-Gerges, A Pointon, GF Pullen, MJ Morton, KL Oldman, D Armstrong, ... Journal of molecular and cellular cardiology 64, 108-119, 2013 | 31 | 2013 |
| In silico approaches in organ toxicity hazard assessment: Current status and future needs for predicting heart, kidney and lung toxicities A Bassan, VM Alves, A Amberg, LT Anger, L Beilke, A Bender, A Bernal, ... Computational Toxicology 20, 100188, 2021 | 23 | 2021 |
| Pivotal role for two electron reduction in 2, 3-dimethoxy-1, 4-naphthoquinone and 2-methyl-1, 4-naphthoquinone metabolism and kinetics in vivo that prevents liver redox stress JD Parry, AV Pointon, U Lutz, F Teichert, JK Charlwood, PH Chan, ... Chemical research in toxicology 22 (4), 717-725, 2009 | 23 | 2009 |
| Regulation of p53 expression, phosphorylation and subcellular localization by a G-protein-coupled receptor L Solyakov, E Sayan, J Riley, A Pointon, AB Tobin Oncogene 28 (41), 3619-3630, 2009 | 20 | 2009 |
| Deriving waveform parameters from calcium transients in human iPSC-derived cardiomyocytes to predict cardiac activity with machine learning H Yang, W Stebbeds, J Francis, A Pointon, O Obrezanova, KA Beattie, ... Stem Cell Reports 17 (3), 556-568, 2022 | 9 | 2022 |
| Cardiovascular microphysiological systems (CVMPS) for safety studies–A pharma perspective A Pointon, J Maher, M Davis, T Baker, J Cichocki, D Ramsden, C Hale, ... Lab on a Chip 21 (3), 458-472, 2021 | 9 | 2021 |
| Information-derived mechanistic hypotheses for structural cardiotoxicity F Svensson, A Zoufir, S Mahmoud, AM Afzal, I Smit, KA Giblin, ... Chemical Research in Toxicology 31 (11), 1119-1127, 2018 | 8 | 2018 |
