| Teaching old receptors new tricks: biasing seven-transmembrane receptors S Rajagopal, K Rajagopal, RJ Lefkowitz Nature reviews Drug discovery 9 (5), 373-386, 2010 | 1005 | 2010 |
| Distinct phosphorylation sites on the β2-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin KN Nobles, K Xiao, S Ahn, AK Shukla, CM Lam, S Rajagopal, ... Science signaling 4 (185), ra51-ra51, 2011 | 698 | 2011 |
| β-arrestin-but not G protein-mediated signaling by the “decoy” receptor CXCR7 S Rajagopal, J Kim, S Ahn, S Craig, CM Lam, NP Gerard, C Gerard, ... Proceedings of the National Academy of Sciences 107 (2), 628-632, 2010 | 681 | 2010 |
| Biased signalling: from simple switches to allosteric microprocessors JS Smith, RJ Lefkowitz, S Rajagopal Nature reviews Drug discovery 17 (4), 243-260, 2018 | 670 | 2018 |
| Therapeutic potential of β-arrestin-and G protein-biased agonists EJ Whalen, S Rajagopal, RJ Lefkowitz Trends in molecular medicine 17 (3), 126-139, 2011 | 616 | 2011 |
| The LOV domain family: photoresponsive signaling modules coupled to diverse output domains S Crosson, S Rajagopal, K Moffat Biochemistry 42 (1), 2-10, 2003 | 553 | 2003 |
| A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1 MR Hara, JJ Kovacs, EJ Whalen, S Rajagopal, RT Strachan, W Grant, ... Nature 477 (7364), 349-353, 2011 | 484 | 2011 |
| Quantifying ligand bias at seven-transmembrane receptors S Rajagopal, S Ahn, DH Rominger, W Gowen-MacDonald, CM Lam, ... Molecular pharmacology 80 (3), 367-377, 2011 | 413 | 2011 |
| The β-arrestins: multifunctional regulators of G protein-coupled receptors JS Smith, S Rajagopal Journal of Biological Chemistry 291 (17), 8969-8977, 2016 | 338 | 2016 |
| GPCR desensitization: Acute and prolonged phases S Rajagopal, SK Shenoy Cellular signalling 41, 9-16, 2018 | 337 | 2018 |
| Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds H Ihee, S Rajagopal, V Šrajer, R Pahl, S Anderson, M Schmidt, F Schotte, ... Proceedings of the National Academy of Sciences 102 (20), 7145-7150, 2005 | 312 | 2005 |
| Multiple ligand-specific conformations of the β2-adrenergic receptor AW Kahsai, K Xiao, S Rajagopal, S Ahn, AK Shukla, J Sun, TG Oas, ... Nature chemical biology 7 (10), 692-700, 2011 | 290 | 2011 |
| Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR) K Xiao, J Sun, J Kim, S Rajagopal, B Zhai, J Villén, W Haas, JJ Kovacs, ... Proceedings of the National Academy of Sciences 107 (34), 15299-15304, 2010 | 226 | 2010 |
| Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9 LM Luttrell, J Wang, B Plouffe, JS Smith, L Yamani, S Kaur, ... Science Signaling 11 (549), eaat7650, 2018 | 198 | 2018 |
| How do chemokines navigate neutrophils to the target site: Dissecting the structural mechanisms and signaling pathways K Rajarathnam, M Schnoor, RM Richardson, S Rajagopal Cellular signalling 54, 69-80, 2019 | 197 | 2019 |
| Application of singular value decomposition to the analysis of time-resolved macromolecular X-ray data M Schmidt, S Rajagopal, Z Ren, K Moffat Biophysical journal 84 (3), 2112-2129, 2003 | 180 | 2003 |
| Biased agonism as a mechanism for differential signaling by chemokine receptors S Rajagopal, DL Bassoni, JJ Campbell, NP Gerard, C Gerard, ... Journal of Biological Chemistry 288 (49), 35039-35048, 2013 | 156 | 2013 |
| Purification and Initial Characterization of a Putative Blue Light‐regulated Phosphodiesterase from Escherichia coli¶ S Rajagopal, JM Key, EB Purcell, DJ Boerema, K Moffat Photochemistry and photobiology 80 (3), 542-547, 2004 | 133 | 2004 |
| Community guidelines for GPCR ligand bias: IUPHAR review 32 P Kolb, T Kenakin, SPH Alexander, M Bermudez, LM Bohn, CS Breinholt, ... British journal of pharmacology 179 (14), 3651-3674, 2022 | 120 | 2022 |
| Protein kinetics: structures of intermediates and reaction mechanism from time-resolved x-ray data M Schmidt, R Pahl, V Srajer, S Anderson, Z Ren, H Ihee, S Rajagopal, ... Proceedings of the National Academy of Sciences 101 (14), 4799-4804, 2004 | 119 | 2004 |
Robert J. LefkowitzJames B. Duke Professor of Medicine, Biochemistry, Chemistry; HHMI, Duke University在 receptor-biol.duke.edu 的电子邮件经过验证
