Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials TA Yap, N Daver, M Mahendra, J Zhang, C Kamiya-Matsuoka, ... Nature medicine 29 (1), 115-126, 2023 | 126 | 2023 |
Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism A Lodi, A Saha, X Lu, B Wang, E Sentandreu, M Collins, MG Kolonin, ... NPJ precision oncology 1 (1), 18, 2017 | 88 | 2017 |
Gilteritinib Inhibits Glutamine Uptake and Utilization in FLT3-ITD–Positive AML ME Zavorka Thomas, X Lu, Z Talebi, JY Jeon, DR Buelow, AA Gibson, ... Molecular cancer therapeutics 20 (11), 2207-2217, 2021 | 32 | 2021 |
Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia N Baran, A Lodi, Y Dhungana, S Herbrich, M Collins, S Sweeney, ... Nature communications 13 (1), 2801, 2022 | 31 | 2022 |
Novel strategy for untargeted chiral metabolomics using liquid chromatography-high resolution tandem mass spectrometry R Pandey, M Collins, X Lu, SR Sweeney, J Chiou, A Lodi, S Tiziani Analytical chemistry 93 (14), 5805-5814, 2021 | 24 | 2021 |
Identification of a synergistic combination of dimethylaminoparthenolide and shikonin alters metabolism and inhibits proliferation of pediatric precursor‐B cell acute … SR Sweeney, M Collins, R Pandey, J Chiou, A Lodi, S Tiziani Molecular Carcinogenesis 59 (4), 399-411, 2020 | 22 | 2020 |
Predicting and quantifying antagonistic effects of natural compounds given with chemotherapeutic agents: Applications for high-throughput screening GL Hackman, M Collins, X Lu, A Lodi, J DiGiovanni, S Tiziani Cancers 12 (12), 3714, 2020 | 19 | 2020 |
The combined treatment with the FLT3-inhibitor AC220 and the complex I inhibitor IACS-010759 synergistically depletes Wt-and FLT3-mutated acute myeloid leukemia cells X Lu, L Han, J Busquets, M Collins, A Lodi, JR Marszalek, M Konopleva, ... Frontiers in Oncology 11, 686765, 2021 | 13 | 2021 |
Metabolomics-based phenotypic screens for evaluation of drug synergy via direct-infusion mass spectrometry X Lu, GL Hackman, A Saha, AS Rathore, M Collins, C Friedman, SS Yi, ... Iscience 25 (5), 2022 | 8 | 2022 |
The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy SM Stanford, M Collins, MA Diaz, ZJ Holmes, P Gries, MR Bliss, A Lodi, ... Journal of cellular physiology 236 (9), 6630-6642, 2021 | 8 | 2021 |
Targeting Oxidative Phosphorylation with a Mitochondrial Complex I Inhibitor is limited by Mechanism-based Toxicity M Konopleva, T Yap, N Daver, M Mahendra, J Zhang, ... | 3 | 2022 |
Isolation of Synergistic Natural Products Targeting Metabolic Dysfunction in Pediatric Pre‐B Cell Acute Lymphoblastic Leukemia Using High‐Throughput Screening and Metabolomics ME Collins, SR Sweeney, S Tiziani The FASEB Journal 33 (S1), lb225-lb225, 2019 | 1 | 2019 |
Exploration of the intracellular chiral metabolome in pediatric BCP-ALL: a pilot study investigating the metabolic phenotype of IgH locus aberrations M Collins, R Gorgoglione, V Impedovo, X Pan, S Chakkarai, SS Yi, A Lodi, ... Frontiers in oncology 14, 1413264, 2024 | | 2024 |
Glutaminase inhibition in combination with azacytidine in myelodysplastic syndromes: Clinical efficacy and correlative analyses M Konopleva, C DiNardo, T Bhagat, N Baran, A Lodi, K Saxena, T Cai, ... Research Square, 2023 | | 2023 |
Lipophagy As a Mechanism of Resistance in T-ALL Following Energetic Crisis Induced By Oxphos/MCT1 Blockade: Strategies to Eradicate Residual Disease N Baran, S Patel, CL Ramage, A Lodi, JE Ortiz, Y Dhungana, M Collins, ... Blood 140 (Supplement 1), 8831-8832, 2022 | | 2022 |
Accumulation of Intracellular L-Lactate and Irreversible Disruption of Mitochondrial Membrane Potential upon Dual Inhibition of Oxphos and Lactate Transporter MCT-1 Induce … N Baran, S Patel, A Lodi, JE Ortiz, Y Dhungana, M Collins, A Skwarska, ... Blood 138, 680, 2021 | | 2021 |
Gilteritinib Inhibits Acute Myeloid Leukemia Growth via Reduction in Glutamine Uptake and Utilization MZ Thomas, JY Jeon, S Shabana, D Buelow, A Gibson, J Anderson, ... The FASEB Journal 34 (S1), 1-1, 2020 | | 2020 |