| Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need MC Field, D Horn, AH Fairlamb, MAJ Ferguson, DW Gray, KD Read, ... Nature Reviews Microbiology 15 (4), 217-231, 2017 | 410 | 2017 |
| Challenges and recent progress in drug discovery for tropical diseases M De Rycker, B Baragaña, SL Duce, IH Gilbert Nature 559 (7715), 498-506, 2018 | 200 | 2018 |
| Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay M De Rycker, I Hallyburton, J Thomas, L Campbell, S Wyllie, D Joshi, ... Antimicrobial agents and chemotherapy 57 (7), 2913-2922, 2013 | 167 | 2013 |
| Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition S Wyllie, S Brand, M Thomas, M De Rycker, C Chung, I Pena, ... Proceedings of the National Academy of Sciences 116 (19), 9318-9323, 2019 | 129 | 2019 |
| Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis S Wyllie, M Thomas, S Patterson, S Crouch, M De Rycker, R Lowe, ... Nature 560 (7717), 192-197, 2018 | 127 | 2018 |
| Vertebrate tankyrase domain structure and sterile alpha motif (SAM)-mediated multimerization M De Rycker, RN Venkatesan, C Wei, CM Price Biochemical Journal 372 (1), 87-96, 2003 | 116 | 2003 |
| Tankyrase polymerization is controlled by its sterile alpha motif and poly (ADP-ribose) polymerase domains M De Rycker, CM Price Molecular and cellular biology 24 (22), 9802-9812, 2004 | 113 | 2004 |
| Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration S Lachmann, A Jevons, M De Rycker, A Casamassima, S Radtke, ... PloS one 6 (7), e21732, 2011 | 92 | 2011 |
| Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas’ disease drug discovery LM MacLean, J Thomas, MD Lewis, I Cotillo, DW Gray, M De Rycker PLoS neglected tropical diseases 12 (7), e0006612, 2018 | 87 | 2018 |
| Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade M De Rycker, J Thomas, J Riley, SJ Brough, TJ Miles, DW Gray PLoS neglected tropical diseases 10 (4), e0004584, 2016 | 75 | 2016 |
| Anti-trypanosomatid drug discovery: progress and challenges M De Rycker, S Wyllie, D Horn, KD Read, IH Gilbert Nature Reviews Microbiology 21 (1), 35-50, 2023 | 74 | 2023 |
| The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis S Patterson, S Wyllie, L Stojanovski, MR Perry, FRC Simeons, S Norval, ... Antimicrobial agents and chemotherapy 57 (10), 4699-4706, 2013 | 71 | 2013 |
| Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani V Corpas-Lopez, S Moniz, M Thomas, RJ Wall, LS Torrie, D Zander-Dinse, ... ACS infectious diseases 5 (1), 111-122, 2018 | 63 | 2018 |
| Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High … A Nühs, M De Rycker, S Manthri, E Comer, CA Scherer, SL Schreiber, ... PLoS Neglected Tropical Diseases 9 (9), e0004094, 2015 | 51 | 2015 |
| ERK2 but not ERK1 mediates HGF-induced motility in non-small cell lung carcinoma cell lines S Radtke, M Milanovic, C Rossé, M De Rycker, S Lachmann, A Hibbert, ... Journal of cell science 126 (11), 2381-2391, 2013 | 50 | 2013 |
| Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi S Brand, EJ Ko, E Viayna, S Thompson, D Spinks, M Thomas, L Sandberg, ... Journal of medicinal chemistry 60 (17), 7284-7299, 2017 | 47 | 2017 |
| Protein kinases, from B to C AJ Cameron, M De Rycker, V Calleja, D Alcor, S Kjaer, B Kostelecky, ... Biochemical Society Transactions 35 (5), 1013-1017, 2007 | 46 | 2007 |
| Identification of GSK3186899/DDD853651 as a preclinical development candidate for the treatment of visceral leishmaniasis MG Thomas, M De Rycker, M Ajakane, S Albrecht, AI Álvarez-Pedraglio, ... Journal of Medicinal Chemistry 62 (3), 1180-1202, 2018 | 40 | 2018 |
| Hit-to-lead optimization of a novel class of potent, broad-spectrum trypanosomacides S Russell, R Rahmani, AJ Jones, HL Newson, K Neilde, I Cotillo, ... Journal of medicinal chemistry 59 (21), 9686-9720, 2016 | 40 | 2016 |
| Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei LAT Cleghorn, S Albrecht, L Stojanovski, FRJ Simeons, S Norval, R Kime, ... Journal of Medicinal Chemistry 58 (19), 7695-7706, 2015 | 35 | 2015 |
