Editing the epigenome: technologies for programmable transcription and epigenetic modulation PI Thakore, JB Black, IB Hilton, CA Gersbach Nature methods 13 (2), 127-137, 2016 | 492 | 2016 |
CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome TS Klann, JB Black, M Chellappan, A Safi, L Song, IB Hilton, GE Crawford, ... Nature biotechnology 35 (6), 561-568, 2017 | 459 | 2017 |
Targeted epigenetic remodeling of endogenous loci by CRISPR/Cas9-based transcriptional activators directly converts fibroblasts to neuronal cells JB Black, AF Adler, HG Wang, AM D’Ippolito, HA Hutchinson, TE Reddy, ... Cell stem cell 19 (3), 406-414, 2016 | 238 | 2016 |
RNA-guided gene editing and gene regulation CA Gersbach, IB Hilton, P Perez-Pinera, AM Kabadi, PI Thakore, ... US Patent 10,704,060, 2020 | 119 | 2020 |
Targeted transcriptional modulation with type I CRISPR–Cas systems in human cells A Pickar-Oliver, JB Black, MM Lewis, KJ Mutchnick, TS Klann, KA Gilcrest, ... Nature biotechnology 37 (12), 1493-1501, 2019 | 89 | 2019 |
Mammalian synthetic biology: engineering biological systems JB Black, P Perez-Pinera, CA Gersbach Annual Review of Biomedical Engineering 19 (1), 249-277, 2017 | 58 | 2017 |
Master regulators and cofactors of human neuronal cell fate specification identified by CRISPR gene activation screens JB Black, SR McCutcheon, S Dube, A Barrera, TS Klann, GA Rice, ... Cell reports 33 (9), 2020 | 46 | 2020 |
Synthetic transcription factors for cell fate reprogramming JB Black, CA Gersbach Current opinion in genetics & development 52, 13-21, 2018 | 26 | 2018 |
CRISPR-based methods for high-throughput annotation of regulatory DNA TS Klann, JB Black, CA Gersbach Current opinion in biotechnology 52, 32-41, 2018 | 22 | 2018 |
RNA-guided gene editing and gene regulation CA Gersbach, IB Hilton, P Perez-Pinera, AM Kabadi, PI Thakore, ... US Patent 10,745,714, 2020 | 20 | 2020 |
Rna-guided gene editing and gene regulation CA Gersbach, IB Hilton, P Perez-Pinera, AM Kabadi, PI Thakore, ... US Patent App. 16/858,689, 2021 | 5 | 2021 |
Rna-guided gene editing and gene regulation CA Gersbach, IB Hilton, P Perez-Pinera, AM Kabadi, PI Thakore, ... US Patent App. 16/927,679, 2021 | 4 | 2021 |
Novel targets for reactivation of prader-willi syndrome-associated genes CA Gersbach, JB Black US Patent App. 18/030,745, 2023 | 2 | 2023 |
Epigenetic modulation of genomic targets to control expression of pws-associated genes CA Gersbach, JB Black US Patent App. 17/766,003, 2022 | 2 | 2022 |
Compositions and methods for identifying regulators of cell type fate specification CA Gersbach, JB Black, J Kwon, S Adkar US Patent App. 17/636,750, 2022 | 2 | 2022 |
Rna-guided gene editing and gene regulation CA Gersbach, IB Hilton, P Perez-Pinera, AM Kabadi, PI Thakore, ... | | 2024 |
Activation of the imprinted Prader-Willi Syndrome locus by CRISPR-based epigenome editing D Rohm, JB Black, SR McCutcheon, A Barrera, DJ Morone, X Nuttle, ... bioRxiv, 2024 | | 2024 |
Compositions, systems, and methods for regulation of hepatitis b virus through targeted gene repression B Cosgrove, K Congdon, J Dean, V Gough, JB Black, B Jones US Patent App. 18/452,514, 2024 | | 2024 |
Compositions, systems, and methods for regulation of hepatitis b virus through targeted gene repression B Cosgrove, K Congdon, J Dean, V Gough, JB Black, B Jones US Patent App. 18/452,508, 2024 | | 2024 |
Host Transcription Factors and Co-Opted Signaling Pathways Orchestrate Epigenetic Modulation of the AAV Vector Genome EM Walton, JB Black, L Castillo, CA Gersbach, A Asokan MOLECULAR THERAPY 30 (4), 430-430, 2022 | | 2022 |