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Arun Thottumkara
Arun Thottumkara
Senior Scientist, Denali Therapeutics
在 dnli.com 的电子邮件经过验证 - 首页
标题
引用次数
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年份
In Situ Generation of o-Iodoxybenzoic Acid (IBX) and the Catalytic Use of It in Oxidation Reactions in the Presence of Oxone as a Co-oxidant
AP Thottumkara, MS Bowsher, TK Vinod
Organic letters 7 (14), 2933-2936, 2005
2662005
Saxitoxin
AP Thottumkara, WH Parsons, J Du Bois
Angewandte Chemie International Edition 53 (23), 5760-5784, 2014
1552014
Synthesis and oxidation reactions of a user-and eco-friendly hypervalent iodine reagent
AP Thottumkara, TK Vinod
Tetrahedron letters 43 (4), 569-572, 2002
1372002
Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth
BJ Lee, JA Boyer, GL Burnett, AP Thottumkara, N Tibrewal, SL Wilson, ...
Nature chemical biology 17 (10), 1065-1074, 2021
552021
Carbocyclization of unsaturated thioesters under palladium catalysis
AP Thottumkara, T Kurokawa, J Du Bois
Chemical Science 4 (6), 2686-2689, 2013
312013
Discovery of RMC-5552, a selective bi-steric inhibitor of mTORC1, for the treatment of mTORC1-activated tumors
GL Burnett, YC Yang, JB Aggen, J Pitzen, MK Gliedt, CM Semko, ...
Journal of medicinal chemistry 66 (1), 149-169, 2022
262022
Discovery of potent and selective dual leucine zipper kinase/leucine zipper-bearing kinase inhibitors with neuroprotective properties in in vitro and in vivo models of …
RA Craig, BM Fox, C Hu, KW Lexa, M Osipov, AP Thottumkara, ...
Journal of Medicinal Chemistry 65 (24), 16290-16312, 2022
92022
Derivatives of amphotericin B
MD Burke, AP Thottumkara, KT Mellem, ZK Sweeney, ES Koltun
US Patent 9,957,290, 2018
62018
Compounds, compositions and methods
AA ESTRADA, B Fox, CP Leslie, JP Lyssikatos, A Pozzan, ZK Sweeney, ...
52017
C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors
J Pitzen, MJE Gliedt, GL Burnett, JB Aggen, K Gert, JJ Cregg, CM Semko, ...
42023
Modulators of eukaryotic initiation factor 2
IIRA Craig, J de Vicente Fidalgo, AA Estrada, JA Feng, BM Fox, KW Lexa, ...
US Patent App. 16/982,471, 2021
42021
C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors
J Pitzen, MJE Gliedt, GL Burnett, JB Aggen, K Gert, CM Semko, W Won, ...
US Patent 10,980,889, 2021
42021
Compounds, compositions and methods
IIRA Craig, J de Vicente Fidalgo, AA Estrada, JA Feng, BM Fox, M Osipov, ...
US Patent 11,306,077, 2022
32022
Rapamycin analogs as mtor inhibitors
JB Aggen, AP Thottumkara, GL Burnett, MJE Gliedt, K Gert, W Won, ...
US Patent App. 16/669,319, 2021
32021
Derivatives of amphotericin B
MD Burke, AP Thottumkara, KT Mellem, ZK Sweeney, ES Koltun
US Patent 10,597,420, 2020
32020
Compounds, compositions and methods
IIRA Craig, J de Vicente Fidalgo, JA Feng, M Osipov, A Thottumkara
US Patent App. 17/430,570, 2022
22022
Compounds, compositions and methods
IIRA Craig, J de Vicente Fidalgo, AA Estrada, JA Feng, KW Lexa, ...
US Patent App. 17/436,297, 2022
22022
C26-linked rapamycin analogs as mtor inhibitors
CM Semko, G Wang, GL BURNETT, JB Aggen, K Gert, JJ CREGG, ...
22019
Rapamycin analogs as mtor inhibitors
C Semko, J Pitzen, G Wang, N Tibrewal, JB Aggen, AP Thottumkara, ...
22018
SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons
T Miyamoto, C Kim, J Chow, JC Dugas, J DeGroot, AL Bagdasarian, ...
Journal of Biological Chemistry 300 (2), 2024
12024
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