In Situ Generation of o-Iodoxybenzoic Acid (IBX) and the Catalytic Use of It in Oxidation Reactions in the Presence of Oxone as a Co-oxidant AP Thottumkara, MS Bowsher, TK Vinod Organic letters 7 (14), 2933-2936, 2005 | 266 | 2005 |
Saxitoxin AP Thottumkara, WH Parsons, J Du Bois Angewandte Chemie International Edition 53 (23), 5760-5784, 2014 | 155 | 2014 |
Synthesis and oxidation reactions of a user-and eco-friendly hypervalent iodine reagent AP Thottumkara, TK Vinod Tetrahedron letters 43 (4), 569-572, 2002 | 137 | 2002 |
Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth BJ Lee, JA Boyer, GL Burnett, AP Thottumkara, N Tibrewal, SL Wilson, ... Nature chemical biology 17 (10), 1065-1074, 2021 | 55 | 2021 |
Carbocyclization of unsaturated thioesters under palladium catalysis AP Thottumkara, T Kurokawa, J Du Bois Chemical Science 4 (6), 2686-2689, 2013 | 31 | 2013 |
Discovery of RMC-5552, a selective bi-steric inhibitor of mTORC1, for the treatment of mTORC1-activated tumors GL Burnett, YC Yang, JB Aggen, J Pitzen, MK Gliedt, CM Semko, ... Journal of medicinal chemistry 66 (1), 149-169, 2022 | 26 | 2022 |
Discovery of potent and selective dual leucine zipper kinase/leucine zipper-bearing kinase inhibitors with neuroprotective properties in in vitro and in vivo models of … RA Craig, BM Fox, C Hu, KW Lexa, M Osipov, AP Thottumkara, ... Journal of Medicinal Chemistry 65 (24), 16290-16312, 2022 | 9 | 2022 |
Derivatives of amphotericin B MD Burke, AP Thottumkara, KT Mellem, ZK Sweeney, ES Koltun US Patent 9,957,290, 2018 | 6 | 2018 |
Compounds, compositions and methods AA ESTRADA, B Fox, CP Leslie, JP Lyssikatos, A Pozzan, ZK Sweeney, ... | 5 | 2017 |
C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors J Pitzen, MJE Gliedt, GL Burnett, JB Aggen, K Gert, JJ Cregg, CM Semko, ... | 4 | 2023 |
Modulators of eukaryotic initiation factor 2 IIRA Craig, J de Vicente Fidalgo, AA Estrada, JA Feng, BM Fox, KW Lexa, ... US Patent App. 16/982,471, 2021 | 4 | 2021 |
C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors J Pitzen, MJE Gliedt, GL Burnett, JB Aggen, K Gert, CM Semko, W Won, ... US Patent 10,980,889, 2021 | 4 | 2021 |
Compounds, compositions and methods IIRA Craig, J de Vicente Fidalgo, AA Estrada, JA Feng, BM Fox, M Osipov, ... US Patent 11,306,077, 2022 | 3 | 2022 |
Rapamycin analogs as mtor inhibitors JB Aggen, AP Thottumkara, GL Burnett, MJE Gliedt, K Gert, W Won, ... US Patent App. 16/669,319, 2021 | 3 | 2021 |
Derivatives of amphotericin B MD Burke, AP Thottumkara, KT Mellem, ZK Sweeney, ES Koltun US Patent 10,597,420, 2020 | 3 | 2020 |
Compounds, compositions and methods IIRA Craig, J de Vicente Fidalgo, JA Feng, M Osipov, A Thottumkara US Patent App. 17/430,570, 2022 | 2 | 2022 |
Compounds, compositions and methods IIRA Craig, J de Vicente Fidalgo, AA Estrada, JA Feng, KW Lexa, ... US Patent App. 17/436,297, 2022 | 2 | 2022 |
C26-linked rapamycin analogs as mtor inhibitors CM Semko, G Wang, GL BURNETT, JB Aggen, K Gert, JJ CREGG, ... | 2 | 2019 |
Rapamycin analogs as mtor inhibitors C Semko, J Pitzen, G Wang, N Tibrewal, JB Aggen, AP Thottumkara, ... | 2 | 2018 |
SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons T Miyamoto, C Kim, J Chow, JC Dugas, J DeGroot, AL Bagdasarian, ... Journal of Biological Chemistry 300 (2), 2024 | 1 | 2024 |