High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9 GK Varshney, W Pei, MC LaFave, J Idol, L Xu, V Gallardo, B Carrington, ... Genome research 25 (7), 1030-1042, 2015 | 552 | 2015 |
Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy RJ Chandler, MC LaFave, GK Varshney, NS Trivedi, N Carrillo-Carrasco, ... The Journal of clinical investigation 125 (2), 870-880, 2015 | 378 | 2015 |
A high-throughput functional genomics workflow based on CRISPR/Cas9-mediated targeted mutagenesis in zebrafish GK Varshney, B Carrington, W Pei, K Bishop, Z Chen, C Fan, L Xu, ... Nature protocols 11 (12), 2357-2375, 2016 | 203 | 2016 |
Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion C Englund, CE Lorén, C Grabbe, GK Varshney, F Deleuil, B Hallberg, ... Nature 425 (6957), 512-516, 2003 | 196 | 2003 |
Multiplex conditional mutagenesis using transgenic expression of Cas9 and sgRNAs L Yin, LA Maddison, M Li, N Kara, MC LaFave, GK Varshney, SM Burgess, ... Genetics 200 (2), 431-441, 2015 | 170 | 2015 |
Expanding the CRISPR toolbox in zebrafish for studying development and disease K Liu, C Petree, T Requena, P Varshney, GK Varshney Frontiers in cell and developmental biology 7, 13, 2019 | 141 | 2019 |
CRISPR-STAT: an easy and reliable PCR-based method to evaluate target-specific sgRNA activity B Carrington, GK Varshney, SM Burgess, R Sood Nucleic acids research 43 (22), e157-e157, 2015 | 132 | 2015 |
A 3D searchable database of transgenic zebrafish Gal4 and Cre lines for functional neuroanatomy studies GD Marquart, KM Tabor, M Brown, JL Strykowski, GK Varshney, ... Frontiers in neural circuits 9, 78, 2015 | 132 | 2015 |
A large-scale zebrafish gene knockout resource for the genome-wide study of gene function GK Varshney, J Lu, DE Gildea, H Huang, W Pei, Z Yang, SC Huang, ... Genome research 23 (4), 727-735, 2013 | 125 | 2013 |
MLV integration site selection is driven by strong enhancers and active promoters MC LaFave, GK Varshney, DE Gildea, TG Wolfsberg, AD Baxevanis, ... Nucleic acids research 42 (7), 4257-4269, 2014 | 112 | 2014 |
Understanding and editing the zebrafish genome GK Varshney, R Sood, SM Burgess Advances in genetics 92, 1-52, 2015 | 103 | 2015 |
A defined zebrafish line for high-throughput genetics and genomics: NHGRI-1 MC LaFave, GK Varshney, M Vemulapalli, JC Mullikin, SM Burgess Genetics 198 (1), 167-170, 2014 | 94 | 2014 |
Long-term correction of Sandhoff disease following intravenous delivery of rAAV9 to mouse neonates JS Walia, N Altaleb, A Bello, C Kruck, MC LaFave, GK Varshney, ... Molecular Therapy 23 (3), 414-422, 2015 | 88 | 2015 |
Extracellular HSP60 triggers tissue regeneration and wound healing by regulating inflammation and cell proliferation W Pei, K Tanaka, SC Huang, L Xu, B Liu, J Sinclair, J Idol, GK Varshney, ... NPJ Regenerative medicine 1 (1), 1-11, 2016 | 64 | 2016 |
Phenotype-driven chemical screening in zebrafish for compounds that inhibit collective cell migration identifies multiple pathways potentially involved in metastatic invasion VE Gallardo, GK Varshney, M Lee, S Bupp, L Xu, P Shinn, NP Crawford, ... Disease models & mechanisms 8 (6), 565-576, 2015 | 63 | 2015 |
Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation Y Yamazaki, C Schönherr, GK Varshney, M Dogru, B Hallberg, ... The EMBO journal 32 (4), 524-537, 2013 | 63 | 2013 |
Genotoxicity in mice following AAV gene delivery: a safety concern for human gene therapy? RJ Chandler, MC LaFave, GK Varshney, SM Burgess, CP Venditti Molecular Therapy 24 (2), 198-201, 2016 | 62 | 2016 |
Mutagenesis and phenotyping resources in zebrafish for studying development and human disease GK Varshney, SM Burgess Briefings in functional genomics 13 (2), 82-94, 2014 | 51 | 2014 |
CRISPRz: a database of zebrafish validated sgRNAs GK Varshney, S Zhang, W Pei, A Adomako-Ankomah, J Fohtung, ... Nucleic acids research 44 (D1), D822-D826, 2016 | 45 | 2016 |
GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126 MR Mahamud, X Geng, YC Ho, B Cha, Y Kim, J Ma, L Chen, G Myers, ... Development 146 (21), dev184218, 2019 | 40 | 2019 |