| Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer KP Olive, MA Jacobetz, CJ Davidson, A Gopinathan, D McIntyre, ... Science 324 (5933), 1457-1461, 2009 | 3569 | 2009 |
| NOTCH1 mediates a switch between two distinct secretomes during senescence M Hoare, Y Ito, TW Kang, MP Weekes, NJ Matheson, DA Patten, S Shetty, ... Nature cell biology 18 (9), 979-992, 2016 | 467 | 2016 |
| Regulation of ERBB2 by oestrogen receptor–PAX2 determines response to tamoxifen A Hurtado, KA Holmes, TR Geistlinger, IR Hutcheson, RI Nicholson, ... Nature 456 (7222), 663-666, 2008 | 415 | 2008 |
| RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer C Cruz, M Castroviejo-Bermejo, S Gutiérrez-Enríquez, A Llop-Guevara, ... Annals of Oncology 29 (5), 1203-1210, 2018 | 367 | 2018 |
| Tissue fixation and the effect of molecular fixatives on downstream staining procedures WJ Howat, BA Wilson Methods 70 (1), 12-19, 2014 | 339 | 2014 |
| High numbers of tumor-infiltrating programmed cell death 1–positive regulatory lymphocytes are associated with improved overall survival in follicular lymphoma J Carreras, A Lopez-Guillermo, G Roncador, N Villamor, L Colomo, ... Journal of Clinical Oncology 27 (9), 1470-1476, 2009 | 335 | 2009 |
| Application of phage display to high throughput antibody generation and characterization DJ Schofield, AR Pope, V Clementel, J Buckell, SDJ Chapple, KF Clarke, ... Genome biology 8, 1-18, 2007 | 313 | 2007 |
| Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets DC Wedge, G Gundem, T Mitchell, DJ Woodcock, I Martincorena, M Ghori, ... Nature genetics 50 (5), 682-692, 2018 | 237 | 2018 |
| Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues G Biffi, D Tannahill, J Miller, WJ Howat, S Balasubramanian PloS one 9 (7), e102711, 2014 | 201 | 2014 |
| SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice A Neesse, KK Frese, DS Chan, TE Bapiro, WJ Howat, FM Richards, ... Gut 63 (6), 974-983, 2014 | 167 | 2014 |
| TGF-β isoform release and activation during in vitro bronchial epithelial wound repair WJ Howat, ST Holgate, PM Lackie American Journal of Physiology-Lung Cellular and Molecular Physiology 282 (1 …, 2002 | 122 | 2002 |
| Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress HC Whitaker, D Patel, WJ Howat, AY Warren, JD Kay, T Sangan, ... British journal of cancer 109 (4), 983-993, 2013 | 117 | 2013 |
| Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma N Cook, KK Frese, TE Bapiro, MA Jacobetz, A Gopinathan, JL Miller, ... Journal of Experimental Medicine 209 (3), 437-444, 2012 | 114 | 2012 |
| Antibody validation of immunohistochemistry for biomarker discovery: recommendations of a consortium of academic and pharmaceutical based histopathology researchers WJ Howat, A Lewis, P Jones, C Kampf, F Pontén, CM van der Loos, ... Methods 70 (1), 34-38, 2014 | 108 | 2014 |
| MRI with hyperpolarised [1-13C] pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model EM Serrao, MI Kettunen, TB Rodrigues, P Dzien, AJ Wright, A Gopinathan, ... Gut 65 (3), 465-475, 2016 | 98 | 2016 |
| Expression profiling by high-throughput immunohistochemistry A Warford, W Howat, J McCafferty Journal of immunological methods 290 (1-2), 81-92, 2004 | 89 | 2004 |
| HES6 drives a critical AR transcriptional programme to induce castration‐resistant prostate cancer through activation of an E 2 F 1‐mediated cell cycle network A Ramos‐Montoya, AD Lamb, R Russell, T Carroll, S Jurmeister, ... EMBO molecular medicine 6 (5), 651-661, 2014 | 86 | 2014 |
| Basement membrane pores in human bronchial epithelium: a conduit for infiltrating cells? WJ Howat, JA Holmes, ST Holgate, PM Lackie The American journal of pathology 158 (2), 673-680, 2001 | 78 | 2001 |
| Use of ex vivo normothermic perfusion for quality assessment of discarded human donor pancreases AD Barlow, MO Hamed, DH Mallon, RJ Brais, FM Gribble, MA Scott, ... American Journal of Transplantation 15 (9), 2475-2482, 2015 | 76 | 2015 |
| Crowdsourcing the general public for large scale molecular pathology studies in cancer FJC Dos Reis, S Lynn, HR Ali, D Eccles, A Hanby, E Provenzano, ... EBioMedicine 2 (7), 681-689, 2015 | 75 | 2015 |
