Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations M Mizuki, J Schwäble, C Steur, C Choudhary, S Agrawal, B Sargin, ... Blood, The Journal of the American Society of Hematology 101 (8), 3164-3173, 2003 | 359 | 2003 |
An interactive environment for agile analysis and visualization of ChIP-sequencing data M Lerdrup, JV Johansen, S Agrawal-Singh, K Hansen Nature structural & molecular biology 23 (4), 349-357, 2016 | 247 | 2016 |
Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia S Göllner, T Oellerich, S Agrawal-Singh, T Schenk, HU Klein, C Rohde, ... Nature medicine 23 (1), 69-78, 2017 | 230 | 2017 |
Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation SS Gehani, S Agrawal-Singh, N Dietrich, NS Christophersen, K Helin, ... Molecular cell 39 (6), 886-900, 2010 | 207 | 2010 |
REST–mediated recruitment of Polycomb repressor complexes in mammalian cells N Dietrich, M Lerdrup, E Landt, S Agrawal-Singh, M Bak, N Tommerup, ... PLoS genetics 8 (3), e1002494, 2012 | 193 | 2012 |
The lncRNA MIR31HG regulates p16INK4A expression to modulate senescence M Montes, MM Nielsen, G Maglieri, A Jacobsen, J Højfeldt, ... Nature communications 6 (1), 6967, 2015 | 178 | 2015 |
The C/EBPδ tumor suppressor is silenced by hypermethylation in acute myeloid leukemia S Agrawal, WK Hofmann, N Tidow, M Ehrich, D Boom, S Koschmieder, ... Blood 109 (9), 3895-3905, 2007 | 145 | 2007 |
Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia C Müller-Tidow, HU Klein, A Hascher, F Isken, L Tickenbrock, ... Blood, The Journal of the American Society of Hematology 116 (18), 3564-3571, 2010 | 111 | 2010 |
Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene S Agrawal-Singh, F Isken, K Agelopoulos, HU Klein, NH Thoennissen, ... Blood, The Journal of the American Society of Hematology 119 (10), 2346-2357, 2012 | 94 | 2012 |
Chromatin modifications induced by PML-RARα repress critical targets in leukemogenesis as analyzed by ChIP-Chip C Hoemme, A Peerzada, G Behre, Y Wang, M McClelland, K Nieselt, ... Blood, The Journal of the American Society of Hematology 111 (5), 2887-2895, 2008 | 86 | 2008 |
DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding T Schoofs, C Rohde, K Hebestreit, HU Klein, S Göllner, I Schulze, ... Blood, The Journal of the American Society of Hematology 121 (1), 178-187, 2013 | 82 | 2013 |
Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6 Y Lu, JH Stuart, C Talbot-Cooper, S Agrawal-Singh, B Huntly, AI Smid, ... Proceedings of the National Academy of Sciences 116 (24), 11997-12006, 2019 | 66 | 2019 |
PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells S Agrawal Singh, M Lerdrup, ALR Gomes, HJG van de Werken, ... Elife 8, e40364, 2019 | 38 | 2019 |
Decitabine and vitamin D3 differentially affect hematopoietic transcription factors to induce monocytic differentiation S Koschmieder, S Agrawal, HS Radomska, CS Huettner, DG Tenen, ... International journal of oncology 30 (2), 349-355, 2007 | 36 | 2007 |
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression H Yun, N Narayan, S Vohra, G Giotopoulos, A Mupo, P Madrigal, D Sasca, ... Nature genetics 53 (10), 1443-1455, 2021 | 23 | 2021 |
Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling N Bäumer, L Tickenbrock, P Tschanter, L Lohmeyer, S Diederichs, ... Journal of Biological Chemistry 286 (32), 28210-28222, 2011 | 23 | 2011 |
Pim2 cooperates with PML-RARα to induce acute myeloid leukemia in a bone marrow transplantation model S Agrawal-Singh, S Koschmieder, S Gelsing, C Stocking, M Stehling, ... Blood, The Journal of the American Society of Hematology 115 (22), 4507-4516, 2010 | 16 | 2010 |
HOXA9 forms a repressive complex with nuclear matrix–associated protein SAFB to maintain acute myeloid leukemia S Agrawal-Singh, J Bagri, G Giotopoulos, DMA Azazi, SJ Horton, ... Blood, The Journal of the American Society of Hematology 141 (14), 1737-1754, 2023 | 7 | 2023 |
Mutational synergy coordinately remodels chromatin accessibility, enhancer landscape and 3-Dimensional DNA topology to alter gene expression during leukemia induction H Yun, S Vohra, A Mupo, G Giotopoulos, D Sasca, SJ Horton, ... Blood 134, 278, 2019 | 2 | 2019 |
HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia B Huntly, S Agrawal Singh, J Bagri, G Giotopoulos, D Azazi, S Horton, ... American Society of Hematology, 2022 | | 2022 |