Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture CK Savile, JM Janey, EC Mundorff, JC Moore, S Tam, WR Jarvis, ... Science 329 (5989), 305-309, 2010 | 1917 | 2010 |
Bayesian reaction optimization as a tool for chemical synthesis BJ Shields, J Stevens, J Li, M Parasram, F Damani, JIM Alvarado, ... Nature 590 (7844), 89-96, 2021 | 581 | 2021 |
Recent advances in catalytic, enantioselective α aminations and α oxygenations of carbonyl compounds JM Janey Angewandte Chemie International Edition 44 (28), 4292-4300, 2005 | 380 | 2005 |
The evolution of high-throughput experimentation in pharmaceutical development and perspectives on the future SM Mennen, C Alhambra, CL Allen, M Barberis, S Berritt, TA Brandt, ... Organic Process Research & Development 23 (6), 1213-1242, 2019 | 361 | 2019 |
Chiral C2‐Symmetric CuII Complexes as Catalysts for Enantioselective Hetero‐Diels–Alder Reactions DA Evans, EJ Olhava, JS Johnson, JM Janey Angewandte Chemie International Edition 37 (24), 3372-3375, 1998 | 179 | 1998 |
Chiral Salen-Aluminum Complexes as Catalysts for Enantioselective Aldol Reactions of Aldehydes and 5-Alkoxyoxazoles: An Efficient Approach to the Asymmetric Synthesis of syn … DA Evans, JM Janey, N Magomedov, JS Tedrow Angewandte Chemie (International Ed. in English) 40 (10), 1884-1888, 2001 | 173 | 2001 |
1-Amino-3-siloxy-1, 3-butadienes: highly reactive dienes for the Diels− Alder reaction SA Kozmin, JM Janey, VH Rawal The Journal of Organic Chemistry 64 (9), 3039-3052, 1999 | 146 | 1999 |
C2-Symmetric Cu(II) Complexes as Chiral Lewis Acids. Catalytic, Enantioselective Cycloadditions of Silyl Ketenes DA Evans, JM Janey Organic Letters 3 (13), 2125-2128, 2001 | 120 | 2001 |
Development of a platform for near-infrared photoredox catalysis BD Ravetz, NES Tay, CL Joe, M Sezen-Edmonds, MA Schmidt, Y Tan, ... ACS central science 6 (11), 2053-2059, 2020 | 110 | 2020 |
High-throughput automation in chemical process development JA Selekman, J Qiu, K Tran, J Stevens, V Rosso, E Simmons, Y Xiao, ... Annual review of chemical and biomolecular engineering 8 (1), 525-547, 2017 | 108 | 2017 |
Proline-catalyzed, asymmetric Mannich reactions in the synthesis of a DPP-IV inhibitor JM Janey, Y Hsiao, JD Armstrong The Journal of Organic Chemistry 71 (1), 390-392, 2006 | 106 | 2006 |
Racemic and Asymmetric Diels− Alder Reactions of 1-(2-Oxazolidinon-3-yl)-3-siloxy-1, 3-butadienes JM Janey, T Iwama, SA Kozmin, VH Rawal The Journal of Organic Chemistry 65 (26), 9059-9068, 2000 | 105 | 2000 |
Fortschritte bei katalytischen enantioselektiven α‐Aminierungen und α‐Oxygenierungen von Carbonylverbindungen JM Janey Angewandte Chemie 117 (28), 4364-4372, 2005 | 84 | 2005 |
Synthesis of the HCV protease inhibitor vaniprevir (MK-7009) using ring-closing metathesis strategy J Kong, C Chen, J Balsells-Padros, Y Cao, RF Dunn, SJ Dolman, J Janey, ... The Journal of Organic Chemistry 77 (8), 3820-3828, 2012 | 81 | 2012 |
Adventures in atropisomerism: total synthesis of a complex active pharmaceutical ingredient with two chirality axes G Beutner, R Carrasquillo, P Geng, Y Hsiao, EC Huang, J Janey, ... Organic letters 20 (13), 3736-3740, 2018 | 54 | 2018 |
Chirale C2‐symmetrische CuII‐Komplexe als Katalysatoren für enantioselektive Hetero‐Diels‐Alder‐Reaktionen DA Evans, EJ Olhava, JS Johnson, JM Janey Angewandte Chemie 110 (24), 3553-3557, 1998 | 47 | 1998 |
Radical biocatalysis: Using non-natural single electron transfer mechanisms to access new enzymatic functions TK Hyster Synlett 31 (03), 248-254, 2020 | 46 | 2020 |
A practical synthesis of 5-lipoxygenase inhibitor MK-0633 F Gosselin, RA Britton, IW Davies, SJ Dolman, D Gauvreau, RS Hoerrner, ... The Journal of Organic Chemistry 75 (12), 4154-4160, 2010 | 46 | 2010 |
Engineered imine reductases and methods for the reductive amination of ketone and amine compounds H Chen, SJ Collier, J Nazor, J Sukumaran, D Smith, JC Moore, G Hughes, ... US Patent 9,487,760, 2016 | 38 | 2016 |
Direct Lewis Acid Catalyzed Conversion of Enantioenriched N-Acyloxazolidinones to Chiral Esters, Amides, and Acids JM Stevens, AC Parra-Rivera, DD Dixon, GL Beutner, AJ DelMonte, ... The Journal of Organic Chemistry 83 (23), 14245-14261, 2018 | 34 | 2018 |