| Coproporphyrins in plasma and urine can be appropriate clinical biomarkers to recapitulate drug-drug interactions mediated by organic anion transporting polypeptide inhibition Y Lai, S Mandlekar, H Shen, VK Holenarsipur, R Langish, P Rajanna, ... Journal of Pharmacology and Experimental Therapeutics 358 (3), 397-404, 2016 | 158 | 2016 |
| Inhibition of AAK1 kinase as a novel therapeutic approach to treat neuropathic pain W Kostich, BD Hamman, YW Li, S Naidu, K Dandapani, J Feng, A Easton, ... Journal of Pharmacology and Experimental Therapeutics 358 (3), 371-386, 2016 | 97 | 2016 |
| Comparative evaluation of plasma bile acids, dehydroepiandrosterone sulfate, hexadecanedioate, and tetradecanedioate with coproporphyrins I and III as markers of OATP … H Shen, W Chen, DM Drexler, S Mandlekar, VK Holenarsipur, EE Shields, ... Drug Metabolism and Disposition 45 (8), 908-919, 2017 | 81 | 2017 |
| Lipophilic salts of poorly soluble compounds to enable high-dose lipidic SEDDS formulations in drug discovery M Morgen, A Saxena, XQ Chen, W Miller, R Nkansah, A Goodwin, J Cape, ... European Journal of Pharmaceutics and Biopharmaceutics 117, 212-223, 2017 | 51 | 2017 |
| Evidence for the validity of pyridoxic acid (PDA) as a plasma-based endogenous probe for OAT1 and OAT3 function in healthy subjects H Shen, VK Holenarsipur, TT Mariappan, DM Drexler, JL Cantone, ... Journal of Pharmacology and Experimental Therapeutics 368 (1), 136-145, 2019 | 47 | 2019 |
| Detection of Weak Organic Anion–Transporting Polypeptide 1B Inhibition by Probenecid with Plasma-Based Coproporphyrin in Humans Y Zhang, VK Holenarsipur, H Kandoussi, J Zeng, TT Mariappan, M Sinz, ... Drug Metabolism and Disposition 48 (10), 841-848, 2020 | 26 | 2020 |
| Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models VK Holenarsipur, N Gaud, J Sinha, S Sivaprasad, P Bhutani, ... Biopharmaceutics & drug disposition 36 (6), 385-397, 2015 | 23 | 2015 |
| Discovery of BMS-986260, a potent, selective, and orally bioavailable TGFβR1 inhibitor as an immuno-oncology agent U Velaparthi, CP Darne, J Warrier, P Liu, H Rahaman, ... ACS Medicinal Chemistry Letters 11 (2), 172-178, 2020 | 20 | 2020 |
| Discovery of (S)-1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable … G Luo, L Chen, WA Kostich, B Hamman, J Allen, A Easton, C Bourin, ... Journal of Medicinal Chemistry 65 (6), 4457-4480, 2022 | 19 | 2022 |
| Endogenous plasma kynurenic acid in human: a newly discovered biomarker for drug-drug interactions involving organic anion transporter 1 and 3 inhibition J Tang, H Shen, X Zhao, VK Holenarsipur, TT Mariappan, Y Zhang, ... Drug Metabolism and Disposition 49 (12), 1063-1069, 2021 | 14 | 2021 |
| Discovery and optimization of biaryl alkyl ethers as a novel class of highly selective, CNS-penetrable, and orally active adaptor protein-2-associated kinase 1 (AAK1 … G Luo, L Chen, WA Kostich, B Hamman, J Allen, A Easton, C Bourin, ... Journal of Medicinal Chemistry 65 (6), 4534-4564, 2022 | 13 | 2022 |
| Single jugular vein cannulated rats may not be suitable for intravenous pharmacokinetic screening of high logP compounds N Gaud, A Kumar, M Matta, P Kole, S Sridhar, S Mandlekar, ... European Journal of Pharmaceutical Sciences 99, 272-278, 2017 | 4 | 2017 |
| TGFβ2 and TGFβ3 mediate appropriate context-dependent phenotype of rat valvular interstitial cells F Wang, C Zhang, J Kwagh, B Strassle, J Li, M Huang, Y Song, B Lehman, ... Iscience 24 (3), 2021 | 3 | 2021 |
| Effect of pretreatment regimens of 1-aminobenzotriazole on metabolism and gastric emptying of probe compounds in rat S Padmanabhan, H Kaur, A Rao, A Saxena, YK Gupta, TT Mariappan, ... Xenobiotica 49 (6), 646-654, 2019 | 2 | 2019 |
| Endogenous plasma kynurenic acid in human: a newly discovered biomarker for drug-drug interactions involving in OAT1 and OAT3 inhibition J Tang, H Shen, X Zhao, VK Holenarsipur, TT Mariappan, Y Zhang, ... Drug Metabolism and Disposition, 2021 | | 2021 |
| Effect of two pretreatment regimens of 1-aminobenzotriazole on metabolism and gastric emptying of probe compounds in rat VK Holenarsipur, S Padmanabhan, H Kaur, A Rao, Y Gupta, T Mariappan Drug Metabolism and Pharmacokinetics 33 (1), S80, 2018 | | 2018 |
